Progesterone Receptor Repression of Prolactin/Signal Transducer and Activator of Transcription 5-Mediated Transcription of the β-Casein Gene in Mammary Epithelial Cells

A simplified system for generating recombinant adenoviruses

1998 • 3,179 citations

STATs: transcriptional control and biological impact

2002 • 3,050 citations

Prolactin (PRL) and Its Receptor: Actions, Signal Transduction Pathways and Phenotypes Observed in PRL Receptor Knockout Mice

1998 • 1,846 citations

Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities.

1995 • 1,834 citations

Stat5a is mandatory for adult mammary gland development and lactogenesis.

1997 • 1,106 citations

Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression

1997 • 989 citations

Estrogen receptor pathways to AP-1

2000 • 867 citations

Endocrine and Paracrine Regulation of Birth at Term and Preterm*

2000 • 842 citations

The Stat family in cytokine signaling

2001 • 723 citations

Subgroup of Reproductive Functions of Progesterone Mediated by Progesterone Receptor-B Isoform

2000 • 693 citations

Functional interactions between Stat5 and the glucocorticoid receptor

1996 • 681 citations

Endocrine and Paracrine Regulation of Birth at Term and Preterm

2000 • 601 citations

Prolactin induces phosphorylation of Tyr694 of Stat5 (MGF), a prerequisite for DNA binding and induction of transcription.

1994 • 599 citations

Hormonal regulation of mammary differentiation and milk secretion.

2002 • 595 citations

The glucocorticoid receptor inhibits NFκB by interfering with serine-2 phosphorylation of the RNA polymerase II carboxy-terminal domain

2000 • 550 citations

Defective mammary gland morphogenesis in mice lacking the progesterone receptor B isoform

2003 • 534 citations

Prolactin regulation of beta-casein gene expression and of a cytosolic 120-kd protein in a cloned mouse mammary epithelial cell line.

1988 • 513 citations

The A and B isoforms of the human progesterone receptor: two functionally different transcription factors encoded by a single gene.

1999 • 337 citations

Prolactin Controls Mammary Gland Development via Direct and Indirect Mechanisms

1999 • 333 citations

Up-Regulation of the Progesterone Receptor (PR)-C Isoform in Laboring Myometrium by Activation of Nuclear Factor-κB May Contribute to the Onset of Labor through Inhibition of PR Function

2005 • 280 citations

A decline in the levels of progesterone receptor coactivators in the pregnant uterus at term may antagonize progesterone receptor function and contribute to the initiation of parturition

2003 • 268 citations

Prolactin and glucocorticoid hormones synergistically induce expression of transfected rat beta-casein gene promoter constructs in a mammary epithelial cell line.

1989 • 257 citations

p300/CREB-Binding Protein Enhances the Prolactin-Mediated Transcriptional Induction through Direct Interaction with the Transactivation Domain of Stat5, but Does Not Participate in the Stat5-Mediated Suppression of the Glucocorticoid Response

1998 • 217 citations

REGULATION OF MILK PROTEIN GENE EXPRESSION

1999 • 217 citations

Unfolding the Action of Progesterone Receptors

2003 • 207 citations

PROGESTERONE WITHDRAWAL AS THE LACTOGENIC TRIGGER IN THE RAT

1969 • 205 citations

Specific DNA Binding of Stat5, but Not of Glucocorticoid Receptor, Is Required for Their Functional Cooperation in the Regulation of Gene Transcription

1997 • 184 citations

Convergence of Progesterone with Growth Factor and Cytokine Signaling in Breast Cancer

1998 • 182 citations

Hormonal regulation of tight junction closure in the mouse mammary epithelium during the transition from pregnancy to lactation

2001 • 181 citations

Prolactin–progesterone antagonism in self regulation of prolactin receptors in the mammary gland

1977 • 180 citations

Mechanism of gene expression by the glucocorticoid receptor: Role of protein‐protein interactions

1997 • 179 citations

Immunologic analysis of human breast cancer progesterone receptors. 1. Immunoaffinity purification of transformed receptors and production of monoclonal antibodies

1987 • 162 citations

A Novel LacZ Reporter Mouse Reveals Complex Regulation of the Progesterone Receptor Promoter During Mammary Gland Development

2002 • 146 citations

Mammary gland growth and development from the postnatal period to postmenopause: ovarian steroid receptor ontogeny and regulation in the mouse.

1998 • 144 citations

The nuclear factor YY1 participates in repression of the beta-casein gene promoter in mammary epithelial cells and is counteracted by mammary gland factor during lactogenic hormone induction.

1994 • 141 citations

Hormonal control of alveolar development and its implications for breast carcinogenesis.

2002 • 138 citations

Serum Progesterone Levels in the Pregnant and Postpartum Laboratory Mouse

1974 • 131 citations

The prolactin/growth hormone receptor family: structure/function relationships.

1997 • 127 citations

Promoter-dependent Synergy between Glucocorticoid Receptor and Stat5 in the Activation of β-Casein Gene Transcription

1997 • 123 citations

Glucocorticoid Receptor/Signal Transducer and Activator of Transcription 5 (STAT5) Interactions Enhance STAT5 Activation by Prolonging STAT5 DNA Binding and Tyrosine Phosphorylation

1999 • 123 citations

Interactions in the transcriptional regulation exerted by Stat5 and by members of the steroid hormone receptor family

1999 • 120 citations

Functional interaction of STAT5 and nuclear receptor co-repressor SMRT: implications in negative regulation of STAT5-dependent transcription

2001 • 113 citations

Identification of a Phosphorylation Site in the Hinge Region of the Human Progesterone Receptor and Additional Amino-terminal Phosphorylation Sites

2001 • 106 citations

Progesterone-mediated inhibition of casein mRNA and polysomal casein synthesis in the rat mammary gland during pregnancy

1978 • 105 citations

Jun Dimerization Protein 2 Functions as a Progesterone Receptor N-Terminal Domain Coactivator

2002 • 102 citations

Hormonal Regulation of Milk Protein Gene Expression

1989 • 100 citations

Glandular Epithelial Cells From Mice: A Method for Selective Cultivation2

1974 • 98 citations

Cooperative Effects of STAT5 (Signal Transducer and Activator of Transcription 5) and C/EBP β (CCAAT/Enhancer-Binding Protein-β) onβ -Casein Gene Transcription Are Mediated by the Glucocorticoid Receptor

2001 • 95 citations

Regulation of a Ca2+-sensitive Adenylyl Cyclase in an Excitable Cell

2000 • 86 citations

YY1 represses beta-casein gene expression by preventing the formation of a lactation-associated complex.

1994 • 84 citations

Comparison of different antibodies for detection of progesterone receptor in breast cancer

2002 • 84 citations

Efficient selection of recombinant adenoviruses by vectors that express beta-galactosidase

1995 • 84 citations

Cross-Talk Between ERs and Signal Transducer and Activator of Transcription 5 Is E2 Dependent and Involves Two Functionally Separate Mechanisms

2001 • 80 citations

Stat5a Serine Phosphorylation

2000 • 79 citations

Integration of Prolactin and Glucocorticoid Signaling at the β-Casein Promoter and Enhancer by Ordered Recruitment of Specific Transcription Factors and Chromatin Modifiers

2006 • 78 citations

The Role of the C-terminal Extension (CTE) of the Estrogen Receptor α and β DNA Binding Domain in DNA Binding and Interaction with HMGB

2004 • 62 citations

The C-terminal Extension (CTE) of the Nuclear Hormone Receptor DNA Binding Domain Determines Interactions and Functional Response to the HMGB-1/-2 Co-regulatory Proteins

2002 • 58 citations

Progesterone and EGF inhibit mouse mammary gland prolactin receptor and beta-casein gene expression

1994 • 57 citations

Inhibition by progesterone of the lactogenic effect of prolactin in the pseudopregnant rabbit

1974 • 56 citations

Expression Level-Dependent Contribution of Glucocorticoid Receptor Domains for Functional Interaction with STAT5

2001 • 51 citations

Cross-talk between Stat5b and estrogen receptor-alpha and -beta in mammary epithelial cells

2001 • 49 citations

A pregnancy-specific mammary nuclear factor involved in the repression of the mouse beta-casein gene transcription by progesterone.

1992 • 49 citations

ERα and STAT5a cross‐talk: interaction through C‐terminal portions of the proteins decreases STAT5a phosphorylation, nuclear translocation and DNA‐binding

2004 • 41 citations

Role of Progesterone and Glucocorticoids in the Transcription of the beta-Casein and 28-S Ribosomal Genes in the Rabbit Mammary Gland

1981 • 40 citations

Estrogen Negatively Regulates Epidermal Growth Factor (EGF)-Mediated Signal Transducer and Activator of Transcription 5 Signaling in Human EGF Family Receptor-Overexpressing Breast Cancer Cells

2005 • 36 citations

The mechanism of progesterone-glucocorticoid interaction in regulation of casein gene expression.

1982 • 34 citations

SPECIFICITY OF PROGESTERONE INHIBITION OF LACTOGENESIS

1969 • 34 citations

Lactogenesis induced by ovariectomy in pregnant rats and its regulation by oestrogen and progesterone

1983 • 31 citations

Estradiol Represses Prolactin-Induced Expression of Na+/Taurocholate Cotransporting Polypeptide in Liver Cells through Estrogen Receptor-α and Signal Transducers and Activators of Transcription 5a

2003 • 30 citations

Progesterone regulation of a pregnancy-specific transcription repressor to beta-casein gene promoter in mouse mammary gland.

1992 • 22 citations

Regulation of milk protein synthesis by progesterone in cultured mouse mammary gland

1988 • 21 citations

Progesterone Withdrawal Stimulates Mammary Gland Tubulin Polymerization in Pregnant Rats*

1985 • 19 citations

Adenoviral-mediated gene transfer in two-dimensional and three-dimensional cultures of mammary epithelial cells

2002 • 13 citations

Specific DNA binding and transactivation potential of recombinant, purified Stat5

2001 • 11 citations

Deleted Work

1955 • 0 citations