Regulation of expression of the human heme oxygenase-1 gene in transfected chick embryo liver cell cultures

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite.

1989 • 1,273 citations

Reporter genes: Application to the study of mammalian gene transcription

1990 • 466 citations

Does carbon monoxide have a physiological function?

1991 • 425 citations

Carbon monoxide: an endogenous modulator of sinusoidal tone in the perfused rat liver.

1995 • 388 citations

Human heme oxygenase cDNA and induction of its mRNA by hemin

1988 • 320 citations

Heme Oxygenase: Clinical Applications and Functions

1992 • 264 citations

Identification of a Second Region Upstream of the Mouse Heme Oxygenase-1 Gene That Functions as a Basal Level and Inducer-dependent Transcription Enhancer

1995 • 219 citations

The Heme-Responsive Element of the Mouse Heme Oxygenase-1 Gene Is an Extended AP-1 Binding Site That Resembles the Recognition Sequences for MAF and NF-E2 Transcription Factors

1996 • 197 citations

The human 32‐kDa stress protein induced by exposure to arsenite and cadmium ions is heme oxygenase

1989 • 163 citations

Modulation of cellular antioxidant defense activities by sodium arsenite in human fibroblasts

1995 • 149 citations

Corticosterone Regulates Heme Oxygenase‐2 and NO Synthase Transcription and Protein Expression In Rat Brain

1994 • 148 citations

Structural organization of the human heme oxygenase gene and the function of its promoter

1989 • 143 citations

Regulation of human heme oxygenase-1 gene expression under thermal stress

1996 • 137 citations

Function and induction of the microsomal heme oxygenase

1983 • 98 citations

Heat‐shock responsive elements in the induction of the multidrug resistance gene (MDR1)

1992 • 81 citations

Hormonal requirements for the induction of cytochrome P450 in hepatocytes cultured in a serum-free medium

1979 • 78 citations

Quercetin, a bioflavonoid, inhibits the increase of human multidrug resistance gene (MDR1) expression caused by arsenite

1992 • 73 citations

Differential requirements for cell-specific elastase I enhancer domains in transfected cells and transgenic mice.

1989 • 72 citations

Enhancement of heme oxygenase-1 synthesis by glutathione depletion in Chinese hamster ovary cells

1991 • 71 citations

Regulation of hepatic haem metabolism. Disparate mechanisms of induction of haem oxygenase by drugs and metals

1988 • 63 citations

The proximal promoter region of the human heme oxygenase gene contains elements involved in stimulation of transcriptional activity by a variety of agents including oxidants

1993 • 62 citations

Interaction of upstream stimulatory factor with the human heme oxygenase gene promoter

1990 • 62 citations

Flavonoids, but not protein kinase c inhibitors, prevent stress protein synthesis during erythrophagocytosis

1991 • 60 citations

Phosphorylation of the RNA polymerase II largest subunit during heat shock and inhibition of transcription in hela cells

1994 • 57 citations

Ethanol-mediated increase in cytochrome p-450 in cultured hepatocytes

1981 • 57 citations

Heme Oxygenase-1 Gene Expression by a Glutathione Depletor, Phorone, Mediated through AP-1 Activation in Rats

1996 • 54 citations

Heat shock induction of heme oxygenase mRNA in human Hep 3B hepatoma cells

1989 • 54 citations

Ultraviolet A (320–380 nm) radiation causes an alteration in the binding of a specific protein/protein complex to a short region of the promoter of the human heme oxygenase 1 gene

1993 • 50 citations

Molecular basis for heme‐dependent induction of heme oxygenase in primary cultures of chick embryo hepatocytes

1993 • 46 citations

Repression of hepatic δ-aminolevulinate synthase by heme and metalloporphyrins: Relationship to inhibition of heme oxygenase

1993 • 41 citations

Heme catabolism in cultured hepatocytes: evidence that heme oxygenase is the predominant pathway and that a proportion of synthesized heme is converted rapidly to biliverdin

1989 • 41 citations

Differential effects of metalloporphyrins on messenger RNA levels of delta-aminolevulinate synthase and heme oxygenase. Studies in cultured chick embryo liver cells.

1994 • 37 citations

Efficient DNA-Mediated Gene Transfer into Primary Cultures of Adult Rat Hepatocytes

1989 • 35 citations

Induction of heme oxygenase-1 in LMH cells. Comparison of LMH cells to primary cultures of chick embryo liver cells

1996 • 32 citations

Iron loading of cultured hepatocytes. Effect of iron on 5-aminolaevulinate synthase is independent of lipid peroxidation

1983 • 31 citations

Regulation of chemical stress-induced hsp70 gene expression in murine L929 cells

1994 • 28 citations

Synergistic induction of δ-aminolevulinate synthase by glutethimide and iron: relationship to the synergistic induction of heme oxygenase

1991 • 22 citations

Repression of ALA synthase by heme and zinc‐mesoporphyrin in a chick embryo liver cell culture model of acute porphyria

1994 • 20 citations

Conversion of 5-aminolaevulinate into haem by homogenates of human liver. Comparison with rat and chick-embryo liver homogenates

1985 • 17 citations

Hyperinducible human metallothionein promoter with a low level basal activity

1994 • 14 citations

Enzymatic basis of metal ion alterations of cellular heme and glutathione metabolism

1981 • 12 citations

Regulation of metallothionein gene expression. Studies in transfected primary cultures of chick embryo liver cells

1996 • 5 citations