Heme catabolism in cultured hepatocytes: evidence that heme oxygenase is the predominant pathway and that a proportion of synthesized heme is converted rapidly to biliverdin

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Microsomal Heme Oxygenase

1969 • 1,348 citations

[4] Isolation and use of liver cells

1978 • 1,230 citations

Hepatology. A Textbook of Liver Disease

1990 • 638 citations

Suicidal Destruction of Cytochrome P-450 During Oxidative Drug Metabolism

1983 • 223 citations

Catabolism of heme in vivo: comparison of the simultaneous production of bilirubin and carbon monoxide

1970 • 186 citations

Induction of aminolevulinate synthase and porphyrins in cultured liver cells maintained in chemically defined medium. Permissive effects of hormones on induction process.

1977 • 160 citations

Purification and properties of bovine spleen heme oxygenase. Amino acid composition and sites of action of inhibitors of heme oxidation.

1982 • 160 citations

Destruction of heme and hemoproteins mediated by liver microsomal reduced nicotinamide adenine dinucleotide phosphate-cytochrome P-450 reductase

1978 • 139 citations

Microsomes and Drug Oxidations

1977 • 131 citations

Characterization of the enzymic and nonenzymic peroxidative degradation of iron porphyrins and cytochrome P-450 heme

1985 • 131 citations

Hemoglobin and Erythrocyte Catabolism in Rat Liver: The Separate Roles of Parenchymal and Sinusoidal Cells

1972 • 103 citations

Rat liver cytochrome P-450b, P-420b, and P-420c are degraded to biliverdin by heme oxygenase

1988 • 95 citations

HAEM catabolism and coupled oxidation of haemproteins

1969 • 94 citations

The Early Appearing Bilirubin: Evidence for Two Components *

1965 • 83 citations

Hormonal requirements for the induction of cytochrome P450 in hepatocytes cultured in a serum-free medium

1979 • 78 citations

The step of carbon monoxide liberation in the sequence of heme degradation catalyzed by the reconstituted microsomal heme oxygenase system.

1982 • 72 citations

High-performance liquid chromatographic separation and quantitation of tetrapyrroles from biological materials

1986 • 69 citations

Regulation of hepatic haem metabolism. Disparate mechanisms of induction of haem oxygenase by drugs and metals

1988 • 63 citations

A comparative study of heme degradation by NADPH-cytochrome c reductase alone and by the complete heme oxygenase system. Distinctive aspects of heme degradation by NADPH-cytochrome c reductase.

1982 • 61 citations

Biosynthesis of porphyrin precursors. Purification and characterization of mammalian L-alanine:gamma,delta-dioxovaleric acid aminotransferase.

1980 • 57 citations

Degradation of endogenous hepatic heme by pathways not yielding carbon monoxide. Studies in normal rat liver and in primary hepatocyte culture.

1980 • 57 citations

Formation and disposition of newly synthesized heme in adult rat hepatocytes in primary culture.

1981 • 53 citations

Immunochemical detection of different isoenzymes of cytochrome P-450 induced in chick hepatocyte cultures

1989 • 52 citations

Hepatology: A textbook of liver disease

1983 • 52 citations

Early-Labeled Peak of Bile Pigment in Man

1967 • 46 citations

Loss of haem from cytochrome P-450 caused by lipid peroxidation and 2-allyl-2-isoprophylacetamide. An abnormal pathway not involving production of carbon monoxide

1977 • 40 citations

Loss of haem and haemoproteins during the generation of superoxide anion and hydrogen peroxide: A pathway not involving production of carbon monoxide

1981 • 38 citations

Methene bridge carbon atom elimination in oxidative heme degradation catalyzed by heme oxygenase and NADPH-cytochrome P-450 reductase

1984 • 35 citations

Enzymic oxidation of unconjugated bilirubin by rat liver

1986 • 34 citations

The turnover of cytochrome P450b

1982 • 31 citations

Role of Cytochrome P-450 in Porphyria Caused by Halogenated Aromatic Compounds

1987 • 19 citations

Metabolism of hepatic haem and ‘green pigments’ in rats given 2-allyl-2-isopropylacetamide and ferric citrate. A new model for hepatic haem turnover

1980 • 16 citations

Isocratic high-performance liquid chromatography of bile pigments

1982 • 16 citations