C-fos antisense oligodeoxynucleotide increases formalin-induced nociception and regulates preprodynorphin expression

Induction of c-fos-like protein in spinal cord neurons following sensory stimulation

1987 • 1,975 citations

Stimulus-transcription coupling in neurons: role of cellular immediate-early genes

1989 • 973 citations

Differential expression of immediate early genes in the hippocampus and spinal cord

1990 • 670 citations

Regulation of Proenkephalin by Fos and Jun

1989 • 546 citations

Sequence and expression of the rat prodynorphin gene.

1985 • 382 citations

Antisense oligodeoxynucleotides to NMDA-R1 receptor channel protect cortical neurons from excitotoxicity and reduce focal ischaemic infarctions

1993 • 374 citations

Standardization of the rat paw formalin test for the evaluation of analgesics

1991 • 359 citations

Specific temporal and spatial distribution of JUN, FOS, and KROX‐24 proteins in spinal neurons following noxious transsynaptic stimulation

1991 • 338 citations

Glutamate receptor agonists increase the expression of Fos, Fra, and AP‐1 DNA binding activity in the mammalian brain

1989 • 330 citations

κ-Opioid receptors and analgesia

1990 • 318 citations

Temporal analysis of increases in c-fos, preprodynorphin and preproenkephalin mRNAs in rat spinal cord

1989 • 311 citations

Molecular pathways of pain: Fos/Jun-mediated activation of a noncanonical AP-1 site in the prodynorphin gene

1991 • 272 citations

Antisense oligonucleotide strategies in neuropharmacology

1994 • 265 citations

Substantia gelatinosa neurones hyperpolarized in vitro by enkephalin

1983 • 236 citations

Dynorphin expression and Fos-like immunoreactivity following inflammation induced hyperalgesia are colocalized in spinal cord neurons

1991 • 235 citations

Up-regulation of opioid gene expression in spinal cord evoked by experimental nerve injuries and inflammation

1991 • 161 citations

Antisense oligonucleotide eliminates in vivo expression of c-fos in mammalian brain

1992 • 158 citations

Antisense oligodeoxynucleotide reduces brain dopamine D2 receptors: Behavioral correlates

1993 • 154 citations

Met-enkephalin levels and opiate receptors in the spinal cord of chronic suffering rats

1980 • 131 citations

Evidence that cholecystokinin induces immediate early gene expression in the brainstem, hypothalamus and amygdala of the rat by a CCKA receptor mechanism

1994 • 123 citations

Induction of the gene encoding pro-dynorphin by experimentally induced arthritis enhances staining for dynorphin in the spinal cord of rats

1989 • 103 citations

Experimental Statistics

1965 • 94 citations

Induction and suppression of immediate-early genes in the rat brain by a selective alpha-2-adrenoceptor agonist and antagonist following noxious peripheral stimulation

1993 • 93 citations

Molecular mechanisms of pain: Serotonin1A receptor agonists trigger transactivation by c-fos of the prodynorphin gene in spinal cord neurons

1993 • 86 citations

Preproenkephalin gene expression in the rat spinal cord after noxious stimuli

1989 • 77 citations

Spontaneous and evoked release of methionine-enkephalin-like material from the rat spinal cord in vivo

1985 • 67 citations

Inhibition of c‐Fos Protein Expression in Rat Spinal Cord by Antisense Oligodeoxynucleotide Superfusion

1994 • 56 citations

Fos-like immunoreactivity in the rat superficial dorsal horn induced by formalin injection in the forepaw: effects of dorsal rhizotomies

1992 • 53 citations

Correlation of ontogeny with function of [3H]U69593 labelled κ opioid binding sites in the rat spinal cord

1989 • 34 citations

The effect of enadoline on immediate early gene expression in the rat paw formalin test

1993 • 3 citations