Correlation of ontogeny with function of [3H]U69593 labelled κ opioid binding sites in the rat spinal cord

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1973 • 12,522 citations

LIGAND: A versatile computerized approach for characterization of ligand-binding systems

1980 • 8,534 citations

The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog.

1976 • 2,883 citations

Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves.

1978 • 2,400 citations

Intrathecal morphine in mice: A new technique

1980 • 1,880 citations

U-50,488: a selective and structurally novel non-Mu (kappa) opioid agonist.

1983 • 795 citations

The effects of morphine and nalorphine-like drugs in the nondependent, morphine-dependent and cyclazocine-dependent chronic spinal dog.

1976 • 467 citations

Anatomy and embryology of the laboratory rat

1986 • 440 citations

[3H]U-69593 a highly selective ligand for the opioid κ receptor

1985 • 439 citations

CHARACTERIZATION OF THE k‐SUBTYPE OF THE OPIATE RECEPTOR IN THE GUINEA‐PIG BRAIN

1981 • 423 citations

In vivo studies on spinal opiate receptor systems mediating antinociception. II. Pharmacological profiles suggesting a differential association of mu, delta and kappa receptors with visceral chemical and cutaneous thermal stimuli in the rat.

1984 • 391 citations

Dynorphin A selectively reduces a large transient (N-type) calcium current of mouse dorsal root ganglion neurons in cell culture.

1987 • 266 citations

Novel opiate binding sites selective for benzomorphan drugs.

1981 • 225 citations

κ‐Opioid agonists produce antinociception after i.v. and i.c.v. but not intrathecal administration in the rat

1988 • 198 citations

Molecular neuroanatomy

1974 • 166 citations

Dynorphin A decreases voltage‐dependent calcium conductance of mouse dorsal root ganglion neurones.

1986 • 150 citations

In vivo evidence for multiple opiate receptors mediating analgesia in the rat spinal cord

1982 • 148 citations

Evidence for multiple “kappa” binding sites by use of opioid peptides in the guinea-pig lumbo-sacral spinal cord

1982 • 139 citations

Autoradiographic localization of mu, delta and kappa opioid receptor binding sites in rat and guinea pig spinal cord

1985 • 114 citations

Spinal analgesia: Comparison of the mu agonist morphine and the kappa agonist ethylketazocine

1981 • 112 citations

Distinct distribution of opioid receptor types in rat lumbar spinal cord

1987 • 91 citations

Analgesic effects of μ-, δ- and κ-opiate agonists and, in particular, dynorphin at the spinal level

1983 • 83 citations

Ontogeny of substance P receptors in rat spinal cord: Quantitative changes in receptor number and differential expression in specific loci

1986 • 82 citations

Kappa opioid receptor activation depresses excitatory synaptic input to rat locus coeruleus neurons in vitro

1987 • 81 citations

PD117302: a selective agonist for the κ‐opioid receptor

1988 • 76 citations

κ Opioid receptor-mediated analgesia in the developing rat

1986 • 73 citations

Analgesic activity of intraspinally administered dynorphin and ethylketocyclazocine

1982 • 71 citations

Highly selective .kappa. opioid analgesics. Synthesis and structure-activity relationships of novel N-[(2-aminocyclohexyl)aryl]acetamide and N-[(2-aminocyclohexyl)aryloxy]acetamide derivatives

1988 • 65 citations

Multiple opiate binding sites in rat spinal cord

1982 • 56 citations

Comparison of mu, delta, and kappa opiate binding sites in rat brain and spinal cord

1984 • 56 citations

Actions of the GABA_B agonist, (−)‐baclofen, on neurones in deep dorsal horn of the rat spinal cord in vitro

1989 • 55 citations

Spinal κ-opioid receptor-mediated antinociception is stimulus-specific

1987 • 55 citations

Benzomorphan binding sites in rat lumbo-sacral spinal cord

1982 • 47 citations

Autoradiographic localization of opiate κ receptors in the rat spinal cord

1983 • 41 citations

Differential association of spinal μ, δ and κ opioid receptors with cutaneous thermal and visceral chemical nociceptive stimuli in the rat

1983 • 41 citations

Postnatal development of the rat dorsal funiculus

1987 • 23 citations

Binding characteristics of kappa opioids in rat brain

1985 • 23 citations

Distribution of opioid binding sites in spinal cord

1987 • 22 citations

Comparison of mu, kappa and sigma preferring agonists for effects on spinal nociceptive and other responses in rats

1984 • 20 citations

Postnatal development of the GABA system in the rat spinal cord.

1982 • 12 citations

The action of K-agonists on the nociceptive responses of neurones in the medullary dorsal horn of the anaesthetized rat

1983 • 9 citations

21. Effects of opioid peptide agonists selective for μ, δ and κ receptors on identified dorsal horn neurons

1985 • 7 citations

Electrophysiological analysis of kappa opiate receptor activation in the rabbit vas deferens

1984 • 2 citations

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