Phenolics: blocking agents for heterocyclic amine-induced carcinogenesis

Rapid metabolic phenotypes for acetyltransferase and cytochrome P4501A2 and putative exposure to food-borne heterocyclic amines increase the risk for colorectal cancer or polyps.

1994 • 393 citations

Meat, cooking methods and colorectal cancer: A case‐referent study in Stockholm

1991 • 325 citations

Synthetic antioxidants: Biochemical actions and interference with radiation, toxic compounds, chemical mutagens and chemical carcinogens

1984 • 233 citations

Carcinogenicity of 2‐Amino‐3‐methylimidazo[4,5‐f]quinoline in Nonhuman Primates: Induction of Tumors in Three Macaques

1990 • 224 citations

Exposure to heterocyclic amines.

1993 • 175 citations

Identification of N-(deoxyguanosin-8-yl)-2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine as the major adduct formed by the food-borne carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, with DNA

1992 • 161 citations

Metabolic activation and covalent binding to nucleic acids of carcinogenic heterocyclic amines from cooked foods and amino acid pyrolysates.

1987 • 148 citations

Characterization of DNA adducts formed in vitro by reaction of N-hydroxy-2-amino-3-methylimidazo[4,5-f]quinoline and N-hydroxy-2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline at the C-8 and N2 atoms of guanine

1992 • 145 citations

Intake of fried meat and risk of cancer: A follow‐up study in finland

1994 • 140 citations

Presence of N²-(deoxyguanosin-8-yl)-2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (dG-C8-MeIQx) in human tissues

1996 • 94 citations

Reaction of N-hydroxylamine and N-acetoxy derivatives of 2-amino-3-methylimidazolo[4,5-f]quinoline with DNA. Synthesis and identification of N-(deoxyguanosin-8-yl)-IQ

1988 • 78 citations

Inhibitory effect of chlorophyllin on PhIP-induced mammary carcinogenesis in female F344 rats

1995 • 72 citations

Chemoprevention of 2-amino-1-methyl-6-phenylimidazo[4, 5-b]-pyridine (PhIP)-induced mammary gland carcinogenesis by antioxidants in F344 female rats

1995 • 64 citations

Inhibitory effects of 1-O-hexyl-2,3,5-trimethylhydroquinone (HTHQ), green tea catechins and other antioxidants on 2-amino-6-methyldipyrido[l,2-a: 3′ ,2′ -d]imidazole (Glu-P-1)-induced rat hepatocarcinogenesis and dose-dependent inhibition by HTHQ of lesion induction by Glu-P-1 or 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx)

1995 • 63 citations

Mutagenicity of human urine caused by ingestion of fried ground beef.

1985 • 49 citations

Evidence of Direct Generation of Oxygen Free Radicals from Heterocyclic Amines by NADPH/Cytochrome P‐450 Reductase in vitro

1992 • 47 citations

Activation and detoxication of N-hydroxy-Trp-P-2 by glutathione and glutathione transferases

1983 • 46 citations

The contribution of N-oxidation to the metabolism of the food-borne carcinogen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in rat hepatocytes

1990 • 36 citations

Prevention by synthetic phenolic antioxidants of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx)- or activated MelQx-induced mutagenesis and MelQx-induced rat hepatocarcinogenesis, and role of antioxidant activity in the prevention of carcinogenesis

1998 • 35 citations

Identification of N-(deoxyguanosin-8-yl)–2-amino-3,4-dimethylimidazo[4,5-f]quinoline (dG-C8–MeIQ) as a major adduct formed by MeIQ with nucleotides in vitro and with DNA in vivo

1994 • 34 citations

Strong anti-mutagenic activity of the novel lipophilic antioxidant 1-O-hexyl-2,3,5-trimethylhydroquinone against heterocyclic amine-induced mutagenesis in the Ames assay and its effect on metabolic activation of 2-Amino-6-methyldipyrido[1,2-a:3′, 2′-d]imidazole (Glu-P-1)

1995 • 23 citations

Prevention by antioxidants of heterocyclic amine-induced carcinogenesis in a rat medium-term liver bioassay: results of extended and combination treatment experiments.

1998 • 20 citations

Superoxide dismutase-mediated reversible conversion of 3-hydroxyamino-l-methyl-5H-pyrido(4,3-b) indole, the N-hydroxy derivative of Trp-P-2, into its nitroso derivative

1988 • 18 citations

Prevention of Chemically Induced Rat Carcinogenesis by Antioxidants: Focus on HTHQ

1997 • 6 citations

Enhancement of the mutagenicity of IQ and MeIQ by nitrite in the Salmonella system

1992 • 6 citations

Induction of DNA Recombination by Activated 3‐Amino‐1‐methyl‐5H‐pyrido[4,3‐b]indole

1995 • 4 citations

Effects of Flavonoids on Cell Cycle and Differentiation in Cancer Cells

1997 • 2 citations