In vitro proguanil activation to cycloguanil by human liver microsomes is mediated by CYP3A isoforms as well as by S‐mephenytoin hydroxylase.

Pharmacogenetics of mephenytoin: A new drug hydroxylation polymorphism in man

1984 • 368 citations

Specificity of substrate and inhibitor probes for human cytochromes P450 1A1 and 1A2.

1993 • 310 citations

Genetic polymorphism of S-mephenytoin hydroxylation

1989 • 292 citations

Metabolism of 2-acetylaminofluorene and benzo(a)pyrene and activation of food-derived heterocyclic amine mutagens by human cytochromes P-450.

1990 • 291 citations

Identification of human liver cytochrome P450 isoforms mediating omeprazole metabolism

1993 • 225 citations

Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily

1991 • 200 citations

Polymorphic hydroxylation of S-mephenytoin and omeprazole metabolism in Caucasian and Chinese subjects

1992 • 179 citations

Slow Omeprazole Metabolizers Are Also Poor S-Mephenytoin Hydroxylators

1990 • 169 citations

The activation of the biguanide antimalarial proguanil co‐segregates with the mephenytoin oxidation polymorphism‐a panel study.

1991 • 162 citations

Estradiol Metabolism by Complementary Deoxyribonucleic Acid-Expressed Human Cytochrome P450s

1990 • 129 citations

Relationship between phenytoin and tolbutamide hydroxylations in human liver microsomes.

1991 • 111 citations

Caffeine as a probe for human cytochromes P450

1992 • 95 citations

The pharmacokinetics and activation of proguanil in man: consequences of variability in drug metabolism.

1990 • 85 citations

In vitro metabolism of the biguanide antimalarials in human liver microsomes: evidence for a role of the mephenytoin hydroxylase (P450 MP) enzyme.

1990 • 67 citations

High-performance liquid chromatographic assay for 4-nitrophenol hydroxylation, a putative cytochrome P-4502E1 activity, in human liver microsomes

1993 • 67 citations

Single dose pharmacokinetics of proguanil and its metabolites in healthy subjects.

1987 • 63 citations

Mephenytoin hydroxylation polymorphism: Characterization of the enzymatic deficiency in liver microsomes of poor metabolizers phenotyped in vivo

1985 • 54 citations

Inter‐subject variability in the metabolism of proguanil to the active metabolite cycloguanil in man.

1989 • 53 citations

Variability in the metabolism of proguanil to the active metabolite cycloguanil in healthy Kenyan adults

1990 • 53 citations

Polymerase chain reaction-directed identification, cloning, and quantification of human CYP2C18 mRNA.

1991 • 43 citations

S-mephenytoin 4-hydroxylase is inherited as an autosomal-recessive trait in Japanese families

1987 • 38 citations

Family studies of mephenytoin hydroxylation deficiency.

1986 • 37 citations

Relation between chloroguanide bioactivation to cycloguanil and the genetically determined metabolism of mephenytoin in humans

1992 • 28 citations

Mephenytoin-type polymorphism of drug oxidation: purification and characterization of a human liver cytochrome P-450 isozyme catalyzing microsomal mephenytoin hydroxylation

1986 • 27 citations

Steady-State Kinetics of Proguanil and Its Active Metabolite, Cycloguanil, in Man

1988 • 18 citations

Deleted Work

1955 • 0 citations