Free radicals and brain damage due to transient middle cerebral artery occlusion: the effect of dimethylthiourea

The Rat Brain in Stereotaxic Coordinates

1982 • 53,055 citations

Reversible middle cerebral artery occlusion without craniectomy in rats.

1989 • 6,875 citations

Delayed neuronal death in the gerbil hippocampus following ischemia

1982 • 2,856 citations

Temporal profile of neuronal damage in a model of transient forebrain ischemia

1982 • 2,695 citations

Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination.

1986 • 2,584 citations

Small Differences in Intraischemic Brain Temperature Critically Determine the Extent of Ischemic Neuronal Injury

1987 • 1,821 citations

Evaluation of 2,3,5-triphenyltetrazolium chloride as a stain for detection and quantification of experimental cerebral infarction in rats.

1986 • 1,257 citations

Role of oxygen free radicals in carcinogenesis and brain ischemia

1990 • 885 citations

Oxidative damage to brain proteins, loss of glutamine synthetase activity, and production of free radicals during ischemia/reperfusion-induced injury to gerbil brain.

1990 • 787 citations

Experimental studies of ischemic brain edema : a new experimental study of ischemic brain edema : 1. A new experimental model of cerebral embolism in rats in which recirculation can be introduced in the ischemic area

1986 • 770 citations

Attenuation of focal cerebral ischemic injury in transgenic mice overexpressing CuZn superoxide dismutase.

1991 • 591 citations

Hypothermia but not the N-methyl-D-aspartate antagonist, MK-801, attenuates neuronal damage in gerbils subjected to transient global ischemia

1990 • 589 citations

Correlation between cerebral blood flow and histologic changes in a new rat model of middle cerebral artery occlusion.

1989 • 516 citations

Penumbral tissues salvaged by reperfusion following middle cerebral artery occlusion in rats.

1992 • 467 citations

The effect of mild hyperthermia and hypothermia on brain damage following 5, 10, and 15 minutes of forebrain ischemia

1990 • 409 citations

Polyethylene glycol-conjugated superoxide dismutase and catalase reduce ischemic brain injury

1989 • 368 citations

Hypoglycemic Brain Injury in the Rat: Correlation of Density of Brain Damage with the EEG Isoelectric Time: A Quantitative Study

1984 • 328 citations

Effects of normothermic versus mild hyperthermic forebrain ischemia in rats.

1990 • 327 citations

Prevention of granulocyte-mediated oxidant lung injury in rats by a hydroxyl radical scavenger, dimethylthiourea.

1984 • 322 citations

Ischemic penumbra in a model of reversible middle cerebral artery occlusion in the rat

1992 • 309 citations

Quantitative assessment of early brain damage in a rat model of focal cerebral ischaemia.

1987 • 302 citations

Experimental studies of ischemic brain edema. 1. A new experimental model of cerebral embolism in rats in which recirculation can be introduced in the ischemic area

1986 • 294 citations

Xanthine oxidase-derived hydrogen peroxide contributes to ischemia reperfusion-induced edema in gerbil brains.

1988 • 208 citations

MK-801 reduced cerebral ischemic injury by inducing hypothermia

1990 • 205 citations

Prevention of Postischemic Hyperthermia Prevents Ischemic Injury of CA₁ Neurons in Gerbils

1990 • 186 citations

Evaluation of 2,3,5-triphenyltetrazolium chloride staining to delineate rat brain infarcts.

1991 • 170 citations

Allopurinol and dimethylthiourea reduce brain infarction following middle cerebral artery occlusion in rats.

1989 • 162 citations

The pharmacotherapy of focal cortical ischaemia in the mouse

1990 • 151 citations

Interrelationships between increased vascular permeability and acute neuronal damage following temperature-controlled brain ischemia in rats

1991 • 142 citations

Morphological lesions in the brain preceding the development of postischemic seizures

1988 • 131 citations

Preservation of brain temperature during ischemia in rats.

1990 • 114 citations

Pre- and post-treatment with MK-801 but not pretreatment alone reduces neocortical damage after focal cerebral ischemia in the rat

1990 • 112 citations

Effects of dimethylthiourea on selective neuronal vulnerability in forebrain ischemia in rats.

1993 • 49 citations

Does Ischemia with Reperfusion Lead to Oxidative Damage to Proteins in the Brain?

1993 • 42 citations