Effect of high-dose methylprednisolone administration on immune functions in multiple sclerosis patients

Rating neurologic impairment in multiple sclerosis

1983 • 14,011 citations

New diagnostic criteria for multiple sclerosis: Guidelines for research protocols

1983 • 7,404 citations

Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm

1994 • 7,068 citations

Defining the clinical course of multiple sclerosis

1996 • 3,606 citations

Immunosuppression by Glucocorticoids: Inhibition of NF-κB Activity Through Induction of IκB Synthesis

1995 • 2,386 citations

Interleukin-1 and interleukin-1 antagonism

1991 • 2,276 citations

Endothelial-Leukocyte Adhesion Molecules

1993 • 1,324 citations

Processing of tumour necrosis factor-α precursor by metalloproteinases

1994 • 1,200 citations

Macrocortin: a polypeptide causing the anti-phospholipase effect of glucocorticoids

1980 • 925 citations

A phospholipase A2 inhibitory protein in rabbit neutrophils induced by glucocorticoids.

1980 • 841 citations

Association between Tumor Necrosis Factor-α and Disease Progression in Patients with Multiple Sclerosis

1991 • 794 citations

The adhesion molecule and cytokine profile of multiple sclerosis lesions

1995 • 761 citations

A mechanism for the antiinflammatory effects of corticosteroids: the glucocorticoid receptor regulates leukocyte adhesion to endothelial cells and expression of endothelial-leukocyte adhesion molecule 1 and intercellular adhesion molecule 1.

1992 • 727 citations

Corticosteroids inhibit murine macrophage Ia expression and interleukin 1 production.

1982 • 665 citations

LEUKOKINETIC STUDIES. IV. THE TOTAL BLOOD, CIRCULATING AND MARGINAL GRANULOCYTE POOLS AND THE GRANULOCYTE TURNOVER RATE IN NORMAL SUBJECTS*

1961 • 626 citations

The Effect of Corticosteroids for Acute Optic Neuritis on the Subsequent Development of Multiple Sclerosis

1993 • 572 citations

BREAKDOWN OF THE BLOOD-BRAIN BARRIER PRECEDES SYMPTOMS AND OTHER MRI SIGNS OF NEW LESIONS IN MULTIPLE SCLEROSIS

1990 • 571 citations

Glucocorticoids selectively inhibit the transcription of the interleukin 1 beta gene and decrease the stability of interleukin 1 beta mRNA.

1988 • 510 citations

T cell gelatinases mediate basement membrane transmigration in vitro.

1995 • 507 citations

Increased production of interferon gamma and tumor necrosis factor precedes clinical manifestation in multiple sclerosis: Do cytokines trigger off exacerbations?

1988 • 404 citations

Immunological Aspects of Experimental Allergic Encephalomyelitis and Multiple Sclerosis

1995 • 381 citations

Glucocorticoids inhibit transcriptional and post-transcriptional expression of interleukin 1 in U937 cells.

1987 • 376 citations

Tumor necrosis factor‐α messenger RNA expression in patients with relapsing‐remitting multiple sclerosis is associated with disease activity

1995 • 336 citations

Matrix Metalloproteinases in the Normal Human Central Nervous System, Microglial Nodules, and Multiple Sclerosis Lesions

1996 • 290 citations

Effect of steroids on CSF matrix metalloproteinases in multiple sclerosis

1996 • 278 citations

Activation of endothelial-leukocyte adhesion molecule 1 (ELAM-1) gene transcription.

1991 • 273 citations

Pathogenesis of multiple sclerosis

1994 • 230 citations

Cytokine mRNA levels in mononuclear blood cells from patients with multiple sclerosis

1994 • 227 citations

High dose steroids in acute relapses of multiple sclerosis: MRI evidence for a possible mechanism of therapeutic effect.

1992 • 190 citations

Transcriptional regulation of the human prointerleukin 1 beta gene.

1987 • 172 citations

Glucocorticoid receptors and glucocorticoid sensitivity of mitogen stimulated and unstimulated human lymphocytes

1977 • 166 citations

A whole-blood technique for testing production of human interferon by leukocytes

1982 • 163 citations

Increases in soluble VCAM‐1 correlate with a decrease in MRI lesions in multiple sclerosis treated with interferon β‐1b

1997 • 155 citations

Circulating adhesion molecules and tumor necrosis factor receptor in multiple sclerosis: Correlation with magnetic resonance imaging

1995 • 150 citations

Steroid hormone receptors in normal human lymphocytes. Induction of glucocorticoid receptor activity by phytohemagglutinin stimulation.

1977 • 134 citations

Regulation of transforming growth factor-beta 1 gene expression by glucocorticoids in normal human T lymphocytes.

1991 • 133 citations

Cytokine-regulated adhesion between encephalitogenic T lymphocytes and cerebrovascular endothelial cells

1993 • 131 citations

Dexamethasone inhibits human interleukin 2 but not interleukin 2 receptor gene expression in vitro at the level of nuclear transcription.

1991 • 112 citations

Tumor necrosis factor alpha production as a possible predictor of relapse in patients with multiple sclerosis.

1992 • 112 citations

Longitudinal study of soluble adhesion molecules in multiple sclerosis

1997 • 87 citations

Transcriptional regulation of the interleukin 2 gene by glucocorticoid hormones. Role of steroid receptor and antigen-responsive 5'-flanking sequences.

1990 • 77 citations

Daily urinary neopterin excretion as an immunological marker of disease activity in multiple sclerosis

1997 • 72 citations

Corticosteroids class-dependently inhibit in vitro Th1- and Th2-type cytokine production

1995 • 68 citations

Prostaglandins and inhibitors of arachidonate metabolism suppress experimental allergic encephalomyelitis

1994 • 65 citations

Cytokine production by peripheral blood monocytes/macrophages in multiple sclerosis patients

1993 • 60 citations

Intravenous Glucocorticosteroid Treatment Augments Apoptosis of Inflammatory T Cells in Experimental Autoimmune Neuritis (EAN) of the Lewis Rat

1995 • 58 citations

The influence of prednisolone on the recirculation of peripheral blood lymphocytes in vivo

1990 • 58 citations

Pulse glucocorticoid therapy. The 'big shot' revisited.

1996 • 50 citations

Pulse Glucocorticoid Therapy

1996 • 46 citations

TGF- β -like activity produced during regression of exacerbations in multiple sclerosis

1991 • 41 citations

Monocytes Are the Major Producers of Interleukin-1β in anEx VivoModel of Local Cytokine Production

1995 • 37 citations

Recombinant human interleukin 1β induces production of prostaglandins in primary human fetal astrocytes and immortalized human fetal astrocyte cultures

1996 • 36 citations

Comparison of the effects of oral versus intravenous methylprednisolone regimens on peripheral blood T lymphocyte adhesion molecule expression, T cell subsets distribution and TNF alpha concentrations in multiple sclerosis

1997 • 36 citations

Methylprednisolone Infusion during Acute Exacerbation of MS: Plasma and CSF Concentrations

1995 • 35 citations

Mechanisms of immunosuppression by glucocorticoids

1996 • 29 citations

Diminished production of type-I interferons and interleukin-2 in patients with multiple sclerosis

1997 • 27 citations

Selegiline hydrochloride and cognition

1991 • 24 citations

The influence of clinical relapses and steroid therapy on the development of Gd-enhancing lesions: a longitudinal MRI study in relapsing-remitting multiple sclerosis patients

1997 • 22 citations

T Cell Lymphokine-Induced Secretion of Cytokines by Monocytes from Patients with Multiple Sclerosis

1993 • 22 citations

The effect of in vivo dexamethasone on lymphocyte subpopulations: Differential response of EAhu rosette-forming cells

1981 • 21 citations

Effect of high-dose steroid therapy on T-cell subpopulations A longitudinal study in MS patients

2009 • 21 citations

Steroids in multiple sclerosis

1994 • 15 citations

CD4 subsets (CD45RA/RO) exhibit differences in proliferative responses, IL-2 and ?-interferon production during intravenous methylprednisolone treatment of multiple sclerosis

1996 • 10 citations

Analysis of peripheral blood lymphocyte phenotype and function during dexamethazone treatment of progressive multiple sclerosis

1991 • 10 citations