Increased Superoxide Generation Is Associated With Pulmonary Hypertension in Fetal Lambs

NAD(P)H Oxidase

2000 • 2,902 citations

Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells.

1994 • 2,753 citations

Mechanisms of Increased Vascular Superoxide Production in Human Diabetes Mellitus

2002 • 970 citations

Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1

1991 • 961 citations

Evidence for enhanced vascular superoxide anion production in nitrate tolerance. A novel mechanism underlying tolerance and cross-tolerance.

1995 • 660 citations

Human fibroblasts release reactive oxygen species in response to interleukin-1 or tumour necrosis factor-α

1989 • 660 citations

Purified cytochrome b from human granulocyte plasma membrane is comprised of two polypeptides with relative molecular weights of 91,000 and 22,000.

1987 • 459 citations

Two Cytosolic Neutrophil Oxidase Components Absent in Autosomal Chronic Granulomatous Disease

1988 • 401 citations

Increased superoxide anion release from human endothelial cells in response to cytokines.

1986 • 365 citations

Two Forms of Autosomal Chronic Granulomatous Disease Lack Distinct Neutrophil Cytosol Factors

1988 • 327 citations

Pulmonary artery NADPH-oxidase is activated in hypoxic pulmonary vasoconstriction.

1996 • 260 citations

Platelet-Derived Growth Factor–Stimulated Superoxide Anion Production Modulates Activation of Transcription Factor NF-κB and Expression of Monocyte Chemoattractant Protein 1 in Human Aortic Smooth Muscle Cells

1997 • 257 citations

ET-1 stimulates pulmonary arterial smooth muscle cell proliferation via induction of reactive oxygen species

2001 • 249 citations

Induction of Apoptosis by Pyrrolidinedithiocarbamate and N-Acetylcysteine in Vascular Smooth Muscle Cells

1996 • 248 citations

The Copper Chaperone CCS Directly Interacts with Copper/Zinc Superoxide Dismutase

1998 • 247 citations

Elevated immunoreactive endothelin-1 levels in newborn infants with persistent pulmonary hypertension

1993 • 220 citations

Overexpression of Human Catalase Inhibits Proliferation and Promotes Apoptosis in Vascular Smooth Muscle Cells

1999 • 214 citations

Smooth Muscle-Mediated Connective Tissue Remodeling in Pulmonary Hypertension

1987 • 199 citations

Persistent fetal circulation: Newly recognized structural features

1976 • 195 citations

Failure of postnatal adaptation of the pulmonary circulation after chronic intrauterine pulmonary hypertension in fetal lambs.

1989 • 180 citations

Purification and characterization of Rac 2. A cytosolic GTP-binding protein that regulates human neutrophil NADPH oxidase.

1992 • 176 citations

Upregulation of p67^phoxand gp91^phoxin aortas from angiotensin II-infused mice

2000 • 170 citations

Ligating the Ductus Arteriosus before Birth Causes Persistent Pulmonary Hypertension in the Newborn Lamb

1989 • 165 citations

Superoxide anion release by human endothelial cells: Synergism between a phorbol ester and a calcium ionophore

1986 • 165 citations

NADPH oxidase: a universal oxygen sensor?

2000 • 165 citations

Regulation of Pulmonary Vascular Tone in the Perinatal Period

1995 • 162 citations

Pulmonary endothelial NO synthase gene expression is decreased in fetal lambs with pulmonary hypertension

1997 • 157 citations

Identification of a Functional Leukocyte-Type NADPH Oxidase in Human Endothelial Cells : A Potential Atherogenic Source of Reactive Oxygen Species

1999 • 138 citations

Lp(a) and LDL induce apoptosis in human endothelial cells and in rabbit aorta: Role of oxidative stress

1999 • 133 citations

Mechanism of Cu,Zn-Superoxide Dismutase Activation by the Human Metallochaperone hCCS

2001 • 121 citations

Ligating the Ductus Arteriosus before birth Remodels the Pulmonary Vasculature of the Lamb

1989 • 118 citations

Disruption of cGMP production in pulmonary arteries isolated from fetal lambs with pulmonary hypertension

1995 • 104 citations

Increased endothelial NOS in lambs with increased pulmonary blood flow and pulmonary hypertension

1998 • 97 citations

Coordinated Regulation of Genes of the Nitric Oxide and Endothelin Pathways during the Development of Pulmonary Hypertension in Fetal Lambs

1998 • 89 citations

Crystal Structure of Reduced Bovine Erythrocyte Superoxide Dismutase at 1.9 Å Resolution

1995 • 88 citations

Persistent Pulmonary Hypertension of the Newborn: Role of Nitric Oxide and Endothelin in Pathophysiology and Treatment

1995 • 70 citations

Dual effect of oxidized LDL on cell cycle in human endothelial cells through oxidative stress

2001 • 63 citations

Persistent Pulmonary Hypertension in the Neonate

1988 • 42 citations

DIPYRIDAMOLE ENHANCES RELAXATIONS AND cGMP GENERATION TO NITRIC OXIDE IN LAMBS WITH PERSISTENT PULMONARY HYPERTENSION (PPHN). • 2090

1996 • 4 citations