Behavioral Toxicity of Anticholinesterase Agents: Methodological, Neurochemical, and Neuropsychological Aspects

Arzneimittelforschung

2005 • 8,820 citations

A JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

1909 • 6,516 citations

Federation Proceedings

2009 • 3,950 citations

Pharmacological Reviews

2024 • 2,716 citations

Inhibition and Learning

1973 • 1,092 citations

Psychopharmacology. A Review of Progress, 1957-1967

1969 • 844 citations

Tolerance to, and dependence on, some non-opiate psychotropic drugs.

1971 • 761 citations

The Cholinergic Synapse and the Site of Memory

1972 • 741 citations

NEURO-PSYCHOPHARMACOLOGY

1968 • 733 citations

Cholinergic mechanisms in the control of behavior by the brain.

1963 • 542 citations

Reinforcement and Behavior

1969 • 469 citations

Evaluation of Drug Activities: Pharmacometrics

1964 • 469 citations

Cholinesterases and Anticholinesterase Agents

1963 • 409 citations

Frontiers in physiological psychology

1966 • 319 citations

PSYCHIATRIC SEQUELÆ OF CHRONIC EXPOSURE TO ORGANOPHOSPHORUS INSECTICIDES

1961 • 314 citations

Behavioral variables affecting the development of amphetamine tolerance

1966 • 302 citations

Pharmacology of organophosphorus cholinesterase inhibitors.

1959 • 286 citations

The Blood-Brain Barrier

1961 • 256 citations

Brain-Acetylcholine and Inhibition

1969 • 231 citations

Activitas nervosa superior

1987 • 202 citations

Animal Behaviour and Drug Action.

1965 • 195 citations

EEG, PSYCHOLOGICAL, AND NEUROLOGICAL ALTERATIONS IN HUMANS WITH ORGANOPHOSPHORUS EXPOSURE*

1969 • 195 citations

Bed with bedpan.

1958 • 189 citations

Impairment of one-trial passive avoidance learning in mice by scopolamine, scopolamine methylbromide, and physostigmine

1967 • 127 citations

Brain Acetylcholine and Habituation

1968 • 123 citations

Hydrophobic areas on the active surface of cholinesterases.

1970 • 115 citations

Toxic PHOSPHORUS ESTERS

1961 • 113 citations

TIMING BEHAVIOR DURING PROLONGED TREATMENT WITH dl‐AMPHETAMINE¹

1961 • 110 citations

Advances in neuropsychopharmacology

1972 • 106 citations

CONTROL OF ACETYLCHOLINE SYNTHESIS?THE INHIBITION OF CHOLINE ACETYLTRANSFERASE BY ACETYLCHOLINE

1969 • 104 citations

Toxic Phosphorus Esters. Chemistry, Metabolism, and Biological Effects.

1961 • 101 citations

Studies on the toxicity and mechanism of action of p-nitrophenyl diethyl thionophosphate.

1949 • 99 citations

International review of neurobiology

1974 • 98 citations

Metabolic Behaviour of Isozymes of Acetylcholinesterase

1968 • 92 citations

Berry CA: Effect of cholinergic drugs on passive avoidance in the mouse.

1967 • 92 citations

Effects of pretrial and posttrial administration of cholinergic and anticholinergic drugs on spontaneous alternation.

1969 • 82 citations

Oximes Antagonistic to Inhibitors of Cholinesterase

1964 • 77 citations

Biochemical toxicology of insecticides

1970 • 73 citations

Modern trends in toxicology

1969 • 66 citations

Chemistry of Purposive Behavior

1969 • 65 citations

A biphasic action of central cholinergic stimulation on behavioral arousal in the rat

1971 • 65 citations

Tolerance to low acetylcholinesterase levels: Modification of behavior without acute behavioral change

1972 • 62 citations

Reactivation of Phosphorylated Acetylcholinesterase

1963 • 62 citations

THE EFFECT OF ACUTE AND CHRONIC TREATMENT WITH DIISOPROPYL FLUOROPHOSPHATE ON CHOLINESTERASE ACTIVITIES OF SOME TISSUES OF THE RAT

1966 • 58 citations

Exploratory behavior in chronic disulfoton poisoning in mice

1971 • 57 citations

THE PENETRATION OF 2-PAM-C14 INTO BRAIN AND THE EFFECT OF CHOLINESTERASE INHIBITORS ON ITS TRANSPORT.

1964 • 57 citations

DELAYED NEUROTOXIC ACTION OF SOME ORGANOPHOSPHORUS COMPOUNDS

1969 • 56 citations

Physostigmine induced hippocampal theta activity and learning in rats

1962 • 56 citations

The reactivating and antidotal actions of n,n'-trimethylenebis (pyridinium-4-aldoxime) (TMB-4) and n,n'-oxydimethylenebis (pyridinum-4-aldoxime) (toxogonin), with particular reference to their effect on phosphorylated acetylcholinesterase in the brain

1966 • 55 citations

Induction of morphine tolerance by material extracted from brain of tolerant animals

1966 • 54 citations

Dissociation of learning in marihuana tolerant rats

1972 • 54 citations

A behavioral and pharmacological analysis of reinforcement withdrawal

1970 • 53 citations

Pharmacologic, Toxicologic, and Therapeutic Properties of Anticholinesterase Agents

1967 • 53 citations

Antagonism of sarin poisoning in rats and guinea pigs by atropine, oximes, and mecamylamine

1970 • 53 citations

EFFECTS OF CHRONIC REDUCTIONS IN BRAIN CHOLINESTERASE ACTIVITY ON ACQUISITION AND EXTINCTION OF A CONDITIONED AVOIDANCE RESPONSE

1961 • 52 citations

Effects of cholinolytic agents on behavior following development of tolerance to low cholinesterase activity

1971 • 51 citations

STUDIES ON DELAYED NEUROTOXICITY PRODUCED BY SOME ORGANOPHOSPHORUS COMPOUNDS

1969 • 50 citations

Oximes Antagonistic to Inhibitors of Cholinesterase

1964 • 48 citations

Organophosphorus Poisons

1961 • 47 citations

Effects of physostigmine on rat brain acetylcholine, acetylcholinesterase and conditioned pole jumping

1968 • 45 citations

Progress in Medicinal Chemistry 7

1972 • 44 citations

Role of brain acetylcholine and dopamine in acute neurotoxic effects of DDT

1971 • 43 citations

Effects of DFP and obidoxime on brain acetylcholine levels and on brain and peripheral cholinesterases

1971 • 42 citations

Carboxylesterase inhibition as an indicator of malathion potentiation in mice.

1971 • 41 citations

Effects of chronic reductions in acetylcholinesterase activity on serial problem-solving behavior.

1967 • 40 citations

Consummatory behavior during tolerance to and withdrawal from chronic depression of cholinesterase activity

1971 • 39 citations

In vivo reactivation by pam of brain cholinesterase inhibited by paraoxon

1960 • 39 citations

Depression of two-way avoidance learning and enhancement of passive avoidance learning by small doses of physostigmine

1970 • 39 citations

Central cholinergic blockade and two-way avoidance acquisition: The role of response disinhibition

1971 • 38 citations

Cholinergic synapses of a periventricular punishment system in the medial hypothalamus

1969 • 38 citations

The reactivation by pyridinium aldoximes of phosphorylated acetylcholinesterase in the central nervous system

1967 • 38 citations

The Reaction of Rats to Diets Containing Octamethyl Pyrophosphoramide (Schradan) and 00-Diethyl-S-Ethylmercaptoethanol Thiophosphate ("Systox")

1954 • 37 citations

Zur Behandlung der schweren Parathion-(E 605�)-Vergiftung mit dem Cholinesterase-Reaktivator Obidoxim (Toxogonin�)

1969 • 37 citations

Behavioral effects of central and peripheral changes in acetylcholine systems.

1969 • 37 citations

BIOCHEMICAL EFFECTS OF AN ORGANOPHOSPHORUS CHOLINESTERASE INHIBITOR ON THE RAT BRAIN*

1969 • 36 citations

Cholinesterase levels and operant extinction.

1966 • 35 citations

Is the central cholinergic nervous system overexploited?

1969 • 34 citations

Changes in acetylcholine content of rat brain by toxic doses of di-isopropyl phosphorofluoridate

1969 • 33 citations

Serial problem-solving behavior.

1967 • 33 citations

Some behavioral effects of cholinergic stimulation in the hippocampus

1969 • 32 citations

Physiological Pharmacology

1968 • 31 citations

STUDIES ON THE MECHANISM OF ACQUIRED TOLERANCE BY RATS OF 0,0-DIETHYL S-2-(ETHYLTHIO)ETHYL PHOSPHORODITHIOATE (DI-SYSTON).

1964 • 30 citations

ACCUMULATION OF ACETYLCHOLINE IN BRAIN AND BLOOD OF ANIMALS POISONED WITH CHOLINESTERASE INHIBITORS

1952 • 30 citations

�ber die Permeation von14C-Obidoxim durch die sog. Blut-Hirnschranke von M�usen und Ratten

1969 • 29 citations

Effects of scopolamine on shuttle-box avoidance and go-no go discrimination: Response-stimulus relationships, pretreatment baselines, and repeated exposure to drug

1968 • 29 citations

EFFECT OF PARASYMPATHETIC DRUGS ON THE CONDITIONED RESPONSE

1947 • 29 citations

Behavioral aspects of cholinergic transmission.

1969 • 28 citations

Altered sensitivity to drugs following repeated injections of a cholinesterase inhibitor to rats

1969 • 28 citations

Distribution and excretion of pyridine-2-aldoxime methiodide (PAM); atropine and PAM in sarin poisoning

1963 • 27 citations

Effects of Reduced Acetylcholinesterase Levels on Extinction of a Conditioned Response

1965 • 27 citations

Antidotal therapie in organophosphate poisoning

1968 • 27 citations

Effects of amphetamine and pilocarpine on eating behavior in rats with chronically low acetylcholinesterase levels

1972 • 26 citations

Psychopharmacologia, Berlin

1966 • 26 citations

Effective doses of some cholinolytics in the treatment of anticholinesterase poisoning

1970 • 26 citations

Reactivation of Paraoxon-inactivated Cholinesterase in the Rat Cerebral Cortex by Pralidoxime Chloride

1966 • 24 citations

Effects of acute and chronic inhibition of cholinesterase upon body weight, food intake, and water intake in the rat.

1966 • 24 citations

Antidotbehandlung bei Alkylphosphatvergiftungen

1970 • 24 citations

EEG of rhesus monkeys following prolonged low-level feeding of pesticides

1971 • 24 citations

Effect of aldrin on the condition avoidance response and electroshock seizure threshold of offspring from aldrin-treated mother

1971 • 22 citations

Influence of trimedoxime and atropine on acetylcholinesterase activity in some parts of the brain of mice poisoned by isopropylmethyl phosphonofluoridate

1971 • 20 citations

Effects of 2-PAMCI and toxogonin of retinal and brain acetylcholinesterase inhibited by sarin

1971 • 20 citations

1 Organophosphorus Pesticides: Pharmacology

1971 • 20 citations

[Treatment of parathion (E 605) poisoning with the cholinesterase-reactivating substance obidoxime (Toxogonin)].

1969 • 20 citations

Acetylcholine content in the brain of rats treated with paraoxon and obidoxime

1970 • 20 citations

The influence of diets containing from 0 to 81 per cent of protein on tolerated doses of pesticides

1971 • 20 citations

Investigations on the parasympatholytic effect of toxogonin on the guinea-pig isolated ileum

1970 • 20 citations

Desensitization of the end-plate membrane following cholinesterase inhibition, an adjustment to a new working situation.

1969 • 19 citations

The effect of the intravenous injection of DFP and atropine on the level of free acetylcholine in the cerebral cortex of the rabbit.

1954 • 19 citations

Extension of tranquilizer action by anticholinesterases

1964 • 19 citations

Acetylcholine content in the brain of rats treated with paraoxon and pyridinium-2-aldoxime methylchloride

1969 • 18 citations

Methodological problems in evaluating the role of cholinergic mechanisms in behavior.

1969 • 18 citations

The method of conditioned reflexes in toxicology and its application for determining the toxicity of small quantities of pesticides

1964 • 18 citations

The acute oral toxicity of Malathion in relation to dietary protein

1969 • 18 citations

Inhibition of acetylcholinesterase in different parts of the rat brain by isopropyl methyl-phosphonofluoridate; in vitro and in vivo experiments

1972 • 18 citations

Differential effects on various conditioned responses in cats caused by intraventricular and intramuscular injections of reserpine and other substances.

1958 • 17 citations

Adaptation to octamethyl pyrophosphoramide in rats

1966 • 17 citations

Behavioral Effects of Low Doses of DDT

1971 • 17 citations

Biological Effects of Pesticides in Mammalian Systems.

1970 • 17 citations

Acquisition and performance effects of scopolamine and of treatment withdrawal in avoidance situations

1972 • 17 citations

The effect of chlorpromazine on the toxicity and biotransformation of parathion in mice.

1971 • 16 citations

[Antidotal therapy in alkylphosphate poisoning].

1968 • 16 citations

Discrimination behavior in rats with reduced cholinesterase activity.

1967 • 16 citations

[Penetration of 14C-obidoxime through the so-called blood-brain barrier of mice and rats].

1969 • 14 citations

Effect of reduced cholinesterase activity on the maintenance of an operant response.

1967 • 14 citations

Effect of tri-o-tolyl phosphate pretreatment on the toxicity and metabolism of parathion and paraoxon in mice

1972 • 14 citations

Chronic reduction of cholinesterase and the extinction of an operant response

1967 • 13 citations

Book Review: The Correlation of Adverse Effects in Man with Observations in Animals

1972 • 13 citations

Effects of Intracerebral Injection of Anticholinesterase Drugs on Behavior in Rats

1958 • 12 citations

[COMPARATIVE STUDIES ON THE POSSIBILITY OF PENETRATION OF SOME ESTERASE-ACTIVATING OXIMES INTO THE CENTRAL NERVOUS SYSTEM].

1965 • 12 citations

Acquisition of new responses by rats during chronic depression of acetylcholinesterase activity.

1971 • 12 citations

Tolerance to the behavioral effects of scopolamine in rats

1967 • 12 citations

The effect of D-amphetamine and physostigmine upon acquisition and retrieval in a single trial learning task.

1967 • 12 citations

BEHAVIORAL EFFECTS OF A CHOLINERGIC STIMULANT IN COMBINATION WITH VARIOUS PSYCHOTHERAPEUTIC AGENTS.

1964 • 12 citations

The effects of centrally and peripherally acting cholinergic drugs on the short-term performance gradient following passive-avoidance training

1970 • 11 citations

[Tuberculosis epidemiology and failures of the antituberculosis campaign for children].

1971 • 9 citations

Eeg patterns during the behavioural desensitization to scopolamine in rats

1969 • 9 citations

Effect of Pralidoxime on Electrical Activity of the Cat Brain

1968 • 7 citations

Increased lethal effects of acutely administered anticholinesterases in female rats prefed with similar agents

1971 • 7 citations

Partial antagonism by cholinesterase reactivators of the effects of organophosphate compounds on shuttle-box avoidance.

1970 • 6 citations

Untersuchungen der neurotoxischen Wirkungen des Phosphatesters Bromophos

1971 • 6 citations

The influence of delayed and immediate exposure to trials upon the effect of chlorpromazine on conditioned avoidance behaviour

1964 • 6 citations

Effect of banol and parathion on operant learning behavior of rats fed adequate and inadequate casein diets

1971 • 6 citations

Stimulus control during chronic reduction of cholinesterase activity

1971 • 5 citations

The relationship between cholinesterase activity and brain permeability to barbitone.

1967 • 5 citations

Quelques aspects de la pharmacologie des synapses cholinergiques et de sa signification centrale.

1969 • 5 citations

Control of a Response after Chronic Reduction of Cholinesterase

1967 • 5 citations

[Electroencephalographic aspects of the antagonism between 2-pyridine aldoxime iodomethylate (PAM) and isopropyl methylfluorophosphate (sarin)].

1960 • 5 citations

Post-criterion discrimination behavior in rats with reduced cholinesterase activity

1967 • 4 citations

INTRODUCTION

1969 • 4 citations

Influence of secondary reinforcers on extinction in rats with reduced levels of cholinesterase activity.

1966 • 4 citations

[Neurotoxic effects of Bromophos, a phosphatester pesticide].

1971 • 4 citations

Topical acetylcholine applications: Electrocortical-behavioral correlations

1971 • 3 citations

Neurotoxicity of drugs

1968 • 3 citations

Biochemical and behavioural effects of some halo-substituted vinyl phosphorus esters

1971 • 3 citations

[Studies on the effect of toxogonin on changes in bioelectric activity and choline esterase activity in the brain of rabbits poisoned with diisopropyl phosphorofluoridate (DFP)].

1966 • 3 citations

Mechanisms of Toxicity: Introduction

1969 • 3 citations

A permeability change in CNS tissue in chronic poisoning with disulfoton

1971 • 3 citations

Cholinesterase inhibition and sexual receptivity in the female rats

1969 • 2 citations

The use of animal tests to predict behavioural effects of chemicals on man.

1970 • 2 citations

Two-way (shuttle-box) avoidance in rats after paraoxon treatment.

1971 • 2 citations

Anticholinesterases

1964 • 2 citations

[The effects of parathion on a conditioned response of "avoidance" in the albino rat. I. Contribution to the study the the hygienico-sanitary problem of "residuals" of organophosphoric insecticides].

1966 • 1 citations

Correlation of prolonged insecticide exposure and the activity of the inhibition of cochlea N1 potential

1972 • 1 citations

[Drop in blood cholinesterase in the course of treatment of onchocerciasis by an organophosphorus compound (Metrifonate)].

1971 • 1 citations

[On the question of change of activity of cholinesterase and of conditioned reflex of animals in methylnitrophos poisoning].

1968 • 1 citations

International Conference on Alternative Insecticides for Vector Control

1971 • 1 citations

[Chemical classification of certain organophosphate pesticides in man and a discussion of their retarded toxicity].

1971 • 1 citations

Comparison of Behavioral Effects of Various Levels of Chronic Di-Syston Poisoning

1969 • 1 citations

[Concept and significance of therapy with antidotes in the course of time].

1968 • 1 citations

MISERE, MAGIE ET PSYCHOTHERAPIE. UNE COMMUNAUTE MAGICO-RELIGIEUSE D'ITALIE MERIDIONALE (Misery, Magic and Psychotherapy, a Magico-religious Community of Mediterranean Italy) by M. Risso. Confinia Psychiatrica 14, no. 2 (1971): 108-32. (In French.)

1973 • 1 citations

Deleted Work

1955 • 0 citations