Polyadenylylation signal of the mouse thymidylate synthase gene was created by insertion of an L1 repetitive element downstream of the open reading frame.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

Hypervariable ‘minisatellite’ regions in human DNA

1985 • 3,789 citations

Transcription termination and 3′ processing: the end is in site!

1985 • 1,482 citations

A rapid single-stranded cloning strategy for producing a sequential series of overlapping clones for use in DNA sequencing: Application to sequencing the corn mitochondrial 18 S rDNA

1985 • 1,051 citations

Haemophilia A resulting from de novo insertion of L1 sequences represents a novel mechanism for mutation in man

1988 • 883 citations

The rapid generation of oligonucleotide-directed mutations at high frequency using phosphorothioate-modified DNA

1985 • 849 citations

The sequence of a large L1Md element reveals a tandemly repeated 5' end and several features found in retrotransposons.

1986 • 326 citations

Position-dependent sequence elements downstream of AAUAAA are required for efficient rabbit β-globin mRNA 3′ end formation

1987 • 229 citations

Polyadenylation of mRNA precursors

1988 • 210 citations

3′ cleavage and polyadenylation of mRNA precursors in vitro requires a poly(A) polymerase, a cleavage factor, and a snRNP

1988 • 205 citations

Separation and characterization of a poly(A) polymerase and a cleavage/specificity factor required for pre-mRNA polyadenylation

1988 • 195 citations

A 64 kd nuclear protein binds to RNA segments that include the AAUAAA polyadenylation motif

1988 • 187 citations

Structural organization of the human alpha-galactosidase A gene: further evidence for the absence of a 3' untranslated region.

1988 • 165 citations

The L1Md long interspersed repeat family in the mouse: almost all examples are truncated at one end

1983 • 150 citations

Nucleotide sequence of a functional cDNA for human thymidylate synthase

1985 • 141 citations

The Sequence of a Large L1Md Element Reveals a Tandemly Repeated 5′ End and Several Features Found in Retrotransposons

1986 • 140 citations

A small nuclear ribonucleoprotein associates with the AAUAAA polyadenylation signal in vitro

1986 • 139 citations

Two proteins crosslinked to RNA containing the adenovirus L3 poly(A) site require the AAUAAA sequence for binding.

1988 • 111 citations

Related polypeptides are encoded by Drosophila F elements, I factors, and mammalian L1 sequences.

1987 • 100 citations

Functional analysis of point mutations in the AAUAAA motif of the SV40 late polyadenylation signal

1989 • 89 citations

The C proteins of heterogeneous nuclear ribonucleoprotein complexes interact with RNA sequences downstream of polyadenylation cleavage sites.

1988 • 86 citations

Structure of the gene for mouse thymidylate synthase. Locations of introns and multiple transcriptional start sites.

1986 • 74 citations

Thymidylate synthase gene amplification in fluorodeoxyuridine-resistant mouse cell lines.

1985 • 70 citations

Sequence of a cDNA for mouse thymidylate synthase reveals striking similarity with the prokaryotic enzyme.

1986 • 58 citations

Thymidylate Synthetase Overproduction in 5-Fluorodeoxyuridine-Resistant Mouse Fibroblasts

1982 • 56 citations

Thymidylate synthase gene expression is stimulated by some (but not all) introns

1989 • 48 citations

Thymidylate synthase-deficient Chinese hamster cells: a selection system for human chromosome 18 and experimental system for the study of thymidylate synthase regulation and fragile X expression.

1985 • 47 citations

Fine-structure analysis of the processing and polyadenylation region of the herpes simplex virus type 1 thymidine kinase gene by using linker scanning, internal deletion, and insertion mutations.

1986 • 41 citations

The C Proteins of Heterogeneous Nuclear Ribonucleoprotein Complexes Interact with RNA Sequences Downstream of Polyadenylation Cleavage Sites

1988 • 38 citations

Construction and expression of mouse thymidylate synthase minigenes.

1988 • 25 citations

Mouse thymidylate synthase messenger RNA lacks a 3' untranslated region.

1986 • 24 citations

Fine-Structure Analysis of the Processing and Polyadenylation Region of the Herpes Simplex Virus Type 1 Thymidine Kinase Gene by Using Linker Scanning, Internal Deletion, and Insertion Mutations

1986 • 20 citations

Analysis of the multiple 5? and 3? termini of poly(A) + and poly(A)? deficient thymidylate synthase mRNA in growth-stimulated mouse fibroblasts

1989 • 7 citations

A mouse thymidylate synthase pseudogene derived from an aberrantly processed RNA molecule

1989 • 6 citations

Identification and Characterization of an L1 Family Sequence with a Very Long Open Reading Frame in the Third Intron of the Human Thy midy late Synthase Gene1

1989 • 3 citations