Dysfunction of mitochondria and oxidative stress in the pathogenesis of Alzheimer's disease: On defects in the cytochrome c oxidase complex and aldehyde detoxification

Hydrogen peroxide mediates amyloid β protein toxicity

1994 • 2,065 citations

Extension of Murine Life Span by Overexpression of Catalase Targeted to Mitochondria

2005 • 1,670 citations

4‐Hydroxynonenal‐Derived Advanced Lipid Peroxidation End Products Are Increased in Alzheimer's Disease

1997 • 1,018 citations

Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease.

1996 • 976 citations

Increased Lipid Peroxidation Precedes Amyloid Plaque Formation in an Animal Model of Alzheimer Amyloidosis

2001 • 776 citations

Increase of Brain Oxidative Stress in Mild Cognitive Impairment

2002 • 563 citations

A novel neurological phenotype in mice lacking mitochondrial manganese superoxide dismutase

1998 • 497 citations

Modification of histidine residues in proteins by reaction with 4-hydroxynonenal.

1992 • 481 citations

β‐Amyloid inhibits integrated mitochondrial respiration and key enzyme activities

2001 • 459 citations

A selective defect of cytochrome c oxidase is present in brain of Alzheimer disease patients

2000 • 459 citations

Molecular abnormality of an inactive aldehyde dehydrogenase variant commonly found in Orientals.

1984 • 442 citations

Lipid peroxidation in aging brain and Alzheimer’s disease1,2 1Guest Editors: Mark A. Smith and George Perry 2This article is part of a series of reviews on “Causes and Consequences of Oxidative Stress in Alzheimer’s Disease.” The full list of papers may be found on the homepage of the journal.

2002 • 440 citations

Alcohol-related cancers and aldehyde dehydrogenase-2 in Japanese alcoholics

1998 • 361 citations

Pivotal Role of Mitochondrial Calcium Uptake in Neural Cell Apoptosis and Necrosis

1999 • 352 citations

β‐Site APP cleaving enzyme up‐regulation induced by 4‐hydroxynonenal is mediated by stress‐activated protein kinases pathways

2005 • 316 citations

Copper-Dependent Inhibition of Human CytochromecOxidase by a Dimeric Conformer of Amyloid-β_1-42

2005 • 314 citations

4-Hydroxynonenal and neurodegenerative diseases

2003 • 313 citations

ABAD enhances Aβ‐induced cell stress via mitochondrial dysfunction

2005 • 241 citations

A New Comprehensive Study on Aging the National Institute for Longevity Sciences, Longitudinal Study of Aging (NILS-LSA)

2000 • 224 citations

Aldose reductase functions as a detoxification system for lipid peroxidation products in vasculitis

1999 • 204 citations

In Alzheimer's Disease, Heme Oxygenase Is Coincident with Alz50, an Epitope of τ Induced by 4‐Hydroxy‐2‐Nonenal Modification

2000 • 202 citations

Reduced platelet cytochrome c oxidase activity in Alzheimer's disease

1994 • 199 citations

Deficiency in Mitochondrial Aldehyde Dehydrogenase Increases the Risk for Late-Onset Alzheimer's Disease in the Japanese Population

2000 • 164 citations

Characterization of the three genotypes of low Km aldehyde dehydrogenase in a Japanese population

1994 • 164 citations

Polymorphisms of Human Aldehyde Dehydrogenases

2000 • 157 citations

Aldehyde dehydrogenase (ALDH) 2 associates with oxidation of methoxyacetaldehyde; in vitro analysis with liver subcellular fraction derived from human and Aldh2 gene targeting mouse

2000 • 154 citations

A Mechanism for the Neuroprotective Effect of Apolipoprotein E

2000 • 129 citations

Deficiency in a mitochondrial aldehyde dehydrogenase increases vulnerability to oxidative stress in PC12 cells

2003 • 126 citations

Mitochondria in Alzheimer's disease

2002 • 122 citations

The Lipid Peroxidation Product 4-Hydroxynonenal Impairs Glutamate and Glucose Transport and Choline Acetyltransferase Activity in NSC-19 Motor Neuron Cells

1999 • 107 citations

Disruption of the Coenzyme Binding Site and Dimer Interface Revealed in the Crystal Structure of Mitochondrial Aldehyde Dehydrogenase “Asian” Variant

2005 • 104 citations

Mitochondrial ALDH2 Deficiency as an Oxidative Stress

2004 • 98 citations

The Aldehyde Dehydrogenase 2 Gene Is a Risk Factor for Hypertension in Japanese but Does Not Alter the Sensitivity to Pressor Effects of Alcohol: The Suita Study.

2001 • 97 citations

A chronic Alzheimer’s model evoked by mitochondrial poison sodium azide for pharmacological investigations

2004 • 81 citations

Decreased platelet cytochrome c oxidase activity is accompanied by increased blood lactate concentration during exercise in patients with Alzheimer disease

2003 • 73 citations

Oxidation of 4‐hydroxy‐2‐nonenal by succinic semialdehyde dehydrogenase (ALDH5A)

2003 • 71 citations

Genetic deficiency of a mitochondrial aldehyde dehydrogenase increases serum lipid peroxides in community-dwelling females

2003 • 52 citations

Assessment of association between mitochondrial aldehyde dehydrogenase polymorphism and Alzheimer’s disease in an older Korean population

2003 • 51 citations

Regional brain cytochrome oxidase activity in β-amyloid precursor protein transgenic mice with the swedish mutation

2003 • 30 citations

Mitochondrial Aldehyde Dehydrogenase in Diabetes Associated With Mitochondrial tRNALeu(UUR) Mutation at Position 3243

1996 • 26 citations

Alcohol dehydrogenase 2 variant is associated with cerebral infarction and lacunae

2004 • 26 citations

A DLST genotype associated with reduced risk for Alzheimer’s disease

1999 • 25 citations

Truncated product of the bifunctional DLST gene involved in biogenesis of the respiratory chain

2003 • 25 citations