Contribution of G Protein Activation to Fluoride Stimulation of Phosphoinositide Hydrolysis in Human Neuroblastoma Cells

Regulation of Polyphosphoinositide-specific Phospholipase C Activity by Purified G _q

1991 • 886 citations

Activation of the β1 isozyme of phospholipase C by α subunits of the Gq class of G proteins

1991 • 774 citations

Selective inhibition of receptor-coupled phospholipase C-dependent processes in human platelets and polymorphonuclear neutrophils.

1990 • 615 citations

Receptor-coupled signal transduction in human polymorphonuclear neutrophils: effects of a novel inhibitor of phospholipase C-dependent processes on cell responsiveness.

1990 • 567 citations

The aminosteroid U-73122 inhibits muscarinic receptor sequestration and phosphoinositide hydrolysis in SK-N-SH neuroblastoma cells. A role for Gp in receptor compartmentation.

1991 • 453 citations

Fluoride complexes of aluminium or beryllium act on G-proteins as reversibly bound analogues of the gamma phosphate of GTP.

1987 • 383 citations

Hormone-stimulated polyphosphoinositide breakdown in rat liver plasma membranes. Roles of guanine nucleotides and calcium.

1986 • 378 citations

Inositol Lipids and Signal Transduction in the Nervous System: An Update

1992 • 260 citations

Protein determination by Lowry's method in the presence of sulfhydryl reagents

1972 • 244 citations

Biochemical differentiation of mechanically dissociated mammalian brain in aggregating cell culture

1976 • 187 citations

Purification of an AlF4- and G-protein beta gamma-subunit-regulated phospholipase C-activating protein

1991 • 135 citations

Muscarinic receptor regulation of cytoplasmic Ca2+ concentrations in human SK-N-SH neuroblastoma cells: Ca2+ requirements for phospholipase C activation.

1989 • 110 citations

Differential receptor occupancy requirements for muscarinic cholinergic stimulation of inositol lipid hydrolysis in brain and in neuroblastomas.

1987 • 105 citations

Guanine nucleotide and NaF stimulation of phospholipase C activity in rat cerebral-cortical membranes. Studies on substrate specificity

1987 • 94 citations

Guanine nucleotide-dependent pertussis-toxin-insensitive stimulation of inositol phosphate formation by carbachol in a membrane preparation from human astrocytoma cells

1986 • 88 citations

Inositol and Phosphoinositides — Metabolism and Regulation

1986 • 82 citations

Thyrotropin-releasing hormone stimulation of polyphosphoinositide hydrolysis in GH3 cell membranes is GTP dependent but insensitive to cholera or pertussis toxin.

1986 • 75 citations

Relationship between agonist-induced muscarinic receptor loss and desensitization of stimulated phosphoinositide turnover in two neuroblastomas: methodological considerations.

1990 • 69 citations

Guanine nucleotide regulation of phospholipase C activity in permeabilized rabbit neutrophils. Inhibition by pertussis toxin and sensitization to submicromolar calcium concentrations

1986 • 69 citations

Modulation of Phosphoinositide Hydrolysis by NaF and Aluminum in Rat Cortical Slices

1988 • 47 citations

Receptor-mediated release of inositol 1,4,5-trisphosphate and inositol 1,4-bisphosphate in rat basophilic leukemia RBL-2H3 cells permeabilized with streptolysin O

1989 • 42 citations

Purification and characterization of PLC-βm, a muscarinic cholinergic regulated phospholipase C from rabbit brain membrane

1990 • 34 citations

Muscarinic Receptor‐Stimulated Phosphoinositide Turnover in Human SK‐N‐SH Neuroblastoma Cells: Differential Inhibition by Agents that Elevate Cyclic AMP

1989 • 33 citations

Fluoride inhibits agonist-induced formation of inositol phosphates in rat cortex

1988 • 32 citations

Differential Regulation of Phosphoinositide Phosphodiesterase Activity in Brain Membranes by Guanine Nucleotides and Calcium

1988 • 28 citations

Polyphosphoinositides are the major source of inositol phosphates in carbamoylcholine-stimulated SK-N-SH neuroblastoma cells.

1990 • 27 citations

Dual effect of fluoride on phosphoinositide metabolism in rat brain cortex. Stimulation of phospholipase C and inhibition of polyphosphoinositide synthesis

1990 • 18 citations

Multiple actions of fluoride ions upon the phosphoinositide cycle in the rat brain

1990 • 15 citations

Guanosine 5′‐O‐Thiotriphosphate and Sodium Fluoride Activate Polyphosphoinositide Hydrolysis in Rat Cortical Membranes by Distinct Mechanisms

1990 • 12 citations

Differential regulation of nicotinic acetylcholine receptor expression by human TE671/RD cells following second messenger modulation and sodium butyrate treatments

1991 • 8 citations

Differential sensitivity of phosphoinositide metabolism to sodium fluoride and carbachol treatments in PC12 cells

1991 • 3 citations