Methotrexate Prevents Renal Injury in Experimental Diabetic Rats via Anti-Inflammatory Actions

Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal antitransforming growth factor-β antibody indb/dbdiabetic mice

2000 • 907 citations

A Comparison of Methotrexate with Placebo for the Maintenance of Remission in Crohn's Disease

2000 • 703 citations

Hyperglycemia and Diabetic Kidney Disease: The Case for Transforming Growth Factor–β as a Key Mediator

1995 • 560 citations

Characterization of protein kinase C beta isoform activation on the gene expression of transforming growth factor-beta, extracellular matrix components, and prostanoids in the glomeruli of diabetic rats.

1997 • 532 citations

Methotrexate versus Cyclosporine in Moderate-to-Severe Chronic Plaque Psoriasis

2003 • 475 citations

Transcription factor-κB (NF-κB) and renal disease

2001 • 474 citations

Anti-inflammatory mechanisms of methotrexate in rheumatoid arthritis

2001 • 409 citations

Early glomerular macrophage recruitment in streptozotocin-induced diabetic rats.

2000 • 327 citations

The Role of Macrophages in Diabetic Glomerulosclerosis

1993 • 312 citations

Intercellular Adhesion Molecule-1–Deficient Mice Are Resistant Against Renal Injury After Induction of Diabetes

2003 • 293 citations

The lipid peroxidation end product 4‐hydroxy‐2,3‐nonenal up‐regulates transforming growth factor β1 expression in the macrophage lineage: a link between oxidative injury and fibrosclerosis ¹

1997 • 264 citations

Studies on Macromolecular Components of Human Glomerular Basement Membrane and Alterations in Diabetes: Decreased Levels of Heparan Sulfate Proteoglycan and Laminin

1987 • 208 citations

Influence of sulphasalazine, methotrexate, and the combination of both on plasma homocysteine concentrations in patients with rheumatoid arthritis

1999 • 207 citations

Mycophenolate mofetil prevents the progressive renal failure induced by 5/6 renal ablation in rats

1999 • 203 citations

Mycophenolate mofetil prevents the development of glomerular injury in experimental diabetes

2003 • 199 citations

Methotrexate Suppresses NF-κB Activation Through Inhibition of IκBα Phosphorylation and Degradation

2001 • 189 citations

Increased Expression of Intercellular Adhesion Molecule-1 (ICAM-1) in Diabetic Rat Glomeruli: Glomerular Hyperfiltration Is a Potential Mechanism of ICAM-1 Upregulation

1997 • 187 citations

FK506 in combination with methotrexate for the prevention of graft- versus-host disease after marrow transplantation from matched unrelated donors

1996 • 156 citations

Homocyst(e)ine: an important risk factor for atherosclerotic vascular disease

1997 • 149 citations

Evidence That Glucose Increases Monocyte Binding to Human Aortic Endothelial Cells

1994 • 145 citations

HMG-CoA reductase inhibitor ameliorates diabetic nephropathy by its pleiotropic effects in rats

2003 • 141 citations

Upregulation of Mesangial Growth Factor and Extracellular Matrix Synthesis by Advanced Glycation End Products Via a Receptor-Mediated Mechanism

1997 • 129 citations

Longterm prospective study of methotrexate in rheumatoid arthritis: conclusion after 132 months of therapy.

1998 • 121 citations

Increased expression of selectins in kidneys of patients with diabetic nephropathy

1998 • 111 citations

Structure-function relationships associated with extracellular matrix alterations in diabetic glomerulopathy.

1994 • 104 citations

Effect of High Glucose Concentrations on Expression of ELAM 1, VCAM-1 and ICAM-1 in HUVEC with and without Cytokine Activation.

2004 • 98 citations

Lysophospholipids increase ICAM-1 expression in HUVEC through a G_i- and NF-κB-dependent mechanism

2004 • 86 citations

Effect of selective proteasome inhibitors on TNF-induced activation of primary and transformed endothelial cells

1999 • 77 citations

Pharmacokinetics and pharmacodynamics of low‐dose methotrexate in the treatment of psoriasis

2002 • 69 citations

Macrophages promote prosclerotic responses in cultured rat mesangial cells

1997 • 64 citations

Methotrexate markedly reduces the expression of vascular E‐selectin, cutaneous lymphocyte‐associated antigen and the numbers of mononuclear leucocytes in psoriatic skin

2004 • 56 citations

Methotrexate inhibits proliferation and regulation of the expression of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 by cultured human umbilical vein endothelial cells

2003 • 53 citations

Role of Macrophages in the Pathogenesis of Diabetic Nephropathy

2001 • 53 citations

A proteasome inhibitor reduces concurrent, sequential, and long-term IL-1β- and TNF-α-induced ECAM expression and adhesion

2003 • 47 citations

Intercellular Adhesion Molecule 1 Mediates Mononuclear Cell Infiltration into Rat Glomeruli after Renal Ablation

1998 • 38 citations

Expression of intercellular adhesion molecules 1 (ICAM-1) via an osmotic effect in human umbilical vein endothelial cells exposed to high glucose medium

1996 • 29 citations

Altered tissue expression pattern of cell adhesion molecules, ICAM-1, E-selectin and VCAM-1, in bullous pemphigoid during methotrexate therapy

2004 • 28 citations

Increased Gene Expression of Insulin-Like Growth Factor-I Receptor in Experimental Diabetic Rat Glomeruli

1996 • 26 citations

Short-term low dose methotrexate ameliorates abnormal bone metabolism and bone loss in adjuvant induced arthritis.

1997 • 24 citations

MTX affects inflammation and tissue destruction differently in the rat AA model.

2001 • 22 citations

Monocyte‐endothelial cell interactions in vitro, with reference to the influence of interleukin‐1 and tumor necrosis factor

1993 • 20 citations

Signaling Transduction Pathway of Angiotensin II in Human Mesangial Cells: Mediation of Focal Adhesion and GTPase Activating Proteins

1999 • 16 citations

Methotrexate regulates ICAM-1 expression in recipients of rat cardiac allografts

1998 • 14 citations

Involvement of NF-κB in High Glucose-induced Alteration of a-methyl-D-glucopyranoside (α-MG) Uptake in Renal Proximal Tubule Cells

2003 • 11 citations

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