Differential Hydroxylation of Salicylate in Core and Penumbra Regions During Focal Reversible Cerebral Ischemia

The Rat Brain in Stereotaxic Coordinates

1982 • 53,055 citations

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

Cerebral ischemia. II. The no-reflow phenomenon.

1968 • 1,346 citations

Evaluation of 2,3,5-triphenyltetrazolium chloride as a stain for detection and quantification of experimental cerebral infarction in rats.

1986 • 1,257 citations

Polymorphonuclear leukocytes occlude capillaries following middle cerebral artery occlusion and reperfusion in baboons.

1991 • 741 citations

Insulin effects on monovalent cation transport and Na-K-ATPase activity

1978 • 692 citations

Oxygen radical mechanisms of brain injury following ischemia and reperfusion

1991 • 657 citations

Nitric Oxide Measured by a Porphyrinic Micro Sensor in Rat Brain after Transient Middle Cerebral Artery Occlusion

1993 • 632 citations

Free Radicals and Brain Damage

1993 • 527 citations

Brain Microdialysis

1989 • 518 citations

Inducible Nitric Oxide Synthase Gene Expression in Brain following Cerebral Ischemia

1995 • 479 citations

Oxygen free radical involvement in ischemia and reperfusion injury to brain

1988 • 429 citations

Sensitive assay of hydroxyl free radical formation utilizing high pressure liquid chromatography with electrochemical detection of phenol and salicylate hydroxylation products

1984 • 394 citations

George E. Brown memorial lecture. Oxygen radicals in cerebral vascular injury.

1985 • 393 citations

Mitochondrial Generation of Reactive Oxygen Species After Brain Ischemia in the Rat

1996 • 390 citations

Oxygen-derived radicals: a link between reperfusion injury and inflammation.

1987 • 389 citations

Brain injury, edema, and vascular permeability changes induced by oxygen‐derived free radicals

1984 • 387 citations

Aromatic hydroxylation as a potential measure of hydroxyl-radical formation in vivo. Identification of hydroxylated derivatives of salicylate in human body fluids

1986 • 374 citations

Inhibition of polymorphonuclear leukocyte adherence suppresses no-reflow after focal cerebral ischemia in baboons.

1992 • 368 citations

Brain Temperature Alters Hydroxyl Radical Production during Cerebral Ischemia/Reperfusion in Rats

1996 • 293 citations

Nitric oxide production during focal cerebral ischemia in rats.

1993 • 272 citations

Hydroxylation of salicylate as an assay for hydroxyl radicals: A cautionary note

1991 • 271 citations

Role of Neutrophils in Radical Production during Ischemia and Reperfusion of the Rat Brain: Effect of Neutrophil Depletion on Extracellular Ascorbyl Radical Formation

1995 • 257 citations

A new model of temporary focal neocortical ischemia in the rat.

1992 • 225 citations

Nitric Oxide Donors Increase Blood Flow and Reduce Brain Damage in Focal Ischemia: Evidence That Nitric Oxide is Beneficial in the Early Stages of Cerebral Ischemia

1994 • 206 citations

The formation of peroxynitrite in vivo from nitric oxide and superoxide

1995 • 197 citations

Detection of free radicals during brain ischemia and reperfusion by spin trapping and microdialysis

1992 • 190 citations

Global Cerebral Ischemia in the Rat: Online Monitoring of Oxygen Free Radical Production Using Chemiluminescence in vivo

1995 • 158 citations

Salicylate hydroxylation as an early marker of in vivo oxidative stress in diabetic patients

1992 • 139 citations

Simultaneous Measurement of Salicylate Hydroxylation and Glutamate Release in the Penumbral Cortex following Transient Middle Cerebral Artery Occlusion in Rats

1996 • 127 citations

Mild postischemic hypothermia limits cerebral injury following transient focal ischemia in rat neocortex

1996 • 122 citations

Potentiation of nitric oxide formation following bilateral carotid occlusion and focal cerebral ischemia in the rat: in vivo detection of the nitric oxide radical by electron paramagnetic resonance spin trapping

1993 • 114 citations

Effects of Intraischemic Hypothermia on Cerebral Damage in a Model of Reversible Focal Ischemia

1993 • 114 citations

Reoxygenation of endothelial cells increases permeability by oxidant-dependent mechanisms.

1992 • 110 citations

Tissue factor contributes to microvascular defects after focal cerebral ischemia.

1993 • 101 citations

Identification of Collaterally Perfused Areas following Focal Cerebral Ischemia in the Rat by Comparison of Gradient Echo and Diffusion-Weighted MRI

1995 • 92 citations

Detection of hydroxyl radicals in rat striatum during transient focal cerebral ischemia: possible implication in tissue damage

1995 • 81 citations

Alpha-Phenyl-Tert-Butyl-Nitrone (PBN) Attenuates Hydroxyl Radical Production During Ischemia-Reperfusion Injury of Rat Brain: An EPR Study

1993 • 74 citations

Calcium-activated proteolysis in rat neocortex induced by transient focal ischemia

1994 • 69 citations

Anoxia/reoxygenation induces hydroxyl free radical formation in brain microvessels

1993 • 63 citations

In vivo evidence of hydroxyl radical formation induced by elevation of extracellular glutamate after cerebral ischemia in the cortex of anesthetized rats

1996 • 57 citations

Role of platelet-activating factor and thromboxane A2 in radical production during ischemia and reperfusion of the rat brain

1996 • 56 citations

A reproducible model of reversible, focal, neocortical ischemia in Sprague-Dawley rat

1993 • 50 citations

Impaired microvascular filling after focal cerebral ischemia in monkeys

1972 • 49 citations

Frontiers in Cerebral Vascular Biology: Transport and Its Regulation

2012 • 46 citations

Oxygen Free‐Radical Reduction of Brain Capillary Rubidium Uptake

1986 • 36 citations

Attenuation of Ischemia-Reperfusion Injury in the Rat Neocortex by the Hydroxyl Radical Scavenger Nicaraven

1997 • 25 citations

Demonstration of the Formation of Hydroxyl Radicals in Acute Myocardial Infarction in Man Using Salicylate as Probe

1992 • 22 citations

Free Radical-Induced Alterations in Endothelial Cell Function

1994 • 18 citations

The Use of Intracerebral Microdialysis to Study Blood-Brain Barrier Transport in Health, After Modification and in Disease

1993 • 5 citations