Beta-Thalassemia: Analysis of Mrna Precursors of a Mutant Human Globin Gene with Defective Splicing Using Peripheral Blood Nucleated Red Blood Cells

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.

1980 • 8,711 citations

Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids

1977 • 3,019 citations

[68] Transcription maps of polyoma virus-specific RNA: Analysis by two-dimensional nuclease S1 gel mapping

1980 • 1,430 citations

Mapping of RNA by a modification of the Berk-Sharp procedure: the 5′ termini of 15 S β-globin mRNA precursor and mature 10 S β-globin mRNA have identical map coordinates

1979 • 1,286 citations

Linkage of β-thalassaemia mutations and β-globin gene polymorphisms with DNA polymorphisms in human β-globin gene cluster

1982 • 937 citations

Detection of sickle cell beta S-globin allele by hybridization with synthetic oligonucleotides.

1983 • 536 citations

Intron sequences involved in lariat formation during pre-mRNA splicing

1985 • 402 citations

Detection of single base substitutions in total genomic DNA

1985 • 375 citations

A single-base change at a splice site in a β0-thalassemic gene causes abnormal RNA splicing

1982 • 372 citations

Insertion of synthetic copies of human globin genes into bacterial plasmids

1978 • 350 citations

[49] DNA analysis in the diagnosis of hemoglobin disorders

1981 • 338 citations

Unstable β-globin mRNA in mRNA-deficient β0 thalassemia

1981 • 267 citations

mRNA splicing efficiency in yeast and the contribution of nonconserved sequences

1985 • 194 citations

Advances in thalassemia research

1984 • 124 citations

A nucleotide change at a splice junction in the human beta-globin gene is associated with beta 0-thalassemia.

1981 • 105 citations

Abnormally spliced messenger RNA in erythroid cells from patients with β+ thalassemia and monkey cells expressing a cloned β+-thalassemic gene

1982 • 91 citations

Detection of the Sickle Gene in the Human Fetus

1972 • 89 citations

Structure and expression of a cloned β°thalassaemic globin gene

1981 • 85 citations

A β°-thalassemic β-globin RNA that is labile in bone marrow cells is relatively stable in HeLa cells

1985 • 27 citations