JPDI, a Novel Endoplasmic Reticulum-resident Protein Containing Both a BiP-interacting J-domain and Thioredoxin-like Motifs

Efficient selection for high-expression transfectants with a novel eukaryotic vector

1991 • 5,120 citations

Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs

1984 • 3,334 citations

The Hsp70 and Hsp60 Chaperone Machines

1998 • 2,793 citations

Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response

2000 • 2,696 citations

A C-terminal signal prevents secretion of luminal ER proteins

1987 • 2,189 citations

IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response

2002 • 1,031 citations

Functional annotation of a full-length mouse cDNA collection

2001 • 663 citations

Mutant analysis links the translocon and BiP to retrograde protein transport for ER degradation

1997 • 556 citations

Role and regulation of the ER chaperone BiP

1999 • 539 citations

Protein Disulfide Isomerase Acts as a Redox-Dependent Chaperone to Unfold Cholera Toxin

2001 • 483 citations

Loss of BiP/GRP78 function blocks translocation of secretory proteins in yeast.

1990 • 435 citations

BiP Acts as a Molecular Ratchet during Posttranslational Transport of Prepro-α Factor across the ER Membrane

1999 • 435 citations

BiP Maintains the Permeability Barrier of the ER Membrane by Sealing the Lumenal End of the Translocon Pore before and Early in Translocation

1998 • 427 citations

The J-domain family and the recruitment of chaperone power

1998 • 396 citations

Interaction of the Thiol-Dependent Reductase ERp57 with Nascent Glycoproteins

1997 • 387 citations

Molecular Chaperones in the Yeast Endoplasmic Reticulum Maintain the Solubility of Proteins for Retrotranslocation and Degradation

2001 • 328 citations

ERp57 Functions as a Subunit of Specific Complexes Formed with the ER Lectins Calreticulin and Calnexin

1999 • 315 citations

Dissociation of Kar2p/BiP from an ER Sensory Molecule, Ire1p, Triggers the Unfolded Protein Response in Yeast

2000 • 302 citations

Translational control by the ER transmembrane kinase/ribonuclease IRE1 under ER stress

2001 • 299 citations

The Requirement for Molecular Chaperones during Endoplasmic Reticulum-associated Protein Degradation Demonstrates That Protein Export and Import Are Mechanistically Distinct

1999 • 286 citations

The NH2-terminal 108 amino acids of the Escherichia coli DnaJ protein stimulate the ATPase activity of DnaK and are sufficient for lambda replication.

1994 • 285 citations

Protein disulfide isomerase: The multifunctional redox chaperone of the endoplasmic reticulum

1999 • 272 citations

A Conserved HPD Sequence of the J-domain Is Necessary for YDJ1 Stimulation of Hsp70 ATPase Activity at a Site Distinct from Substrate Binding

1996 • 258 citations

Identification and Characterization of a Novel Endoplasmic Reticulum (ER) DnaJ Homologue, Which Stimulates ATPase Activity of BiP in Vitro and Is Induced by ER Stress

2002 • 202 citations

Protein disulfide isomerases exploit synergy between catalytic and specific binding domains

2002 • 180 citations

Protein folding in the ER

1999 • 171 citations

The 170-kDa glucose-regulated stress protein is an endoplasmic reticulum protein that binds immunoglobulin.

1993 • 163 citations

A yeast DnaJ homologue, Scj1p, can function in the endoplasmic reticulum with BiP/Kar2p via a conserved domain that specifies interactions with Hsp70s.

1995 • 151 citations

The Lumenal Domain of Sec63p Stimulates the ATPase Activity of BiP and Mediates BiP Recruitment to the Translocon in Saccharomyces cerevisiae

1997 • 151 citations

Characterization of the active site cysteine residues of the thioredoxin-like domains of protein disulfide isomerase

1995 • 128 citations

The Dynamic Organisation of the Secretory Pathway.

1996 • 109 citations

HEDJ, an Hsp40 Co-chaperone Localized to the Endoplasmic Reticulum of Human Cells

2000 • 107 citations

BiP and PDI Cooperate in the Oxidative Folding of Antibodiesin Vitro

2000 • 107 citations

Interaction of Murine BiP/GRP78 with the DnaJ Homologue MTJ1

2000 • 100 citations

Divergent Effects of ATP on the Binding of the DnaK and DnaJ Chaperones to Each Other, or to Their Various Native and Denatured Protein Substrates

1995 • 100 citations

A Role for the DnaJ Homologue Scj1p in Protein Folding in the Yeast Endoplasmic Reticulum

1998 • 91 citations

Characterization of the Nucleotide Binding Properties and ATPase Activity of Recombinant Hamster BiP Purified from Bacteria

1995 • 89 citations

A novel type of co-chaperone mediates transmembrane recruitment of DnaK-like chaperones to ribosomes

2002 • 70 citations

Identification of a novel mammalian endoplasmic reticulum-resident KDEL protein using an EST database motif search

2000 • 11 citations