Pain activation of human supraspinal opioid pathways as demonstrated by [11C]-carfentanil and positron emission tomography (PET)
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References (64)
Statistical parametric maps in functional imaging: A general linear approach
1994 • 9,606 citations
The capsaicin receptor: a heat-activated ion channel in the pain pathway
1997 • 8,634 citations
A unified statistical approach for determining significant signals in images of cerebral activation
1996 • 2,680 citations
Functional imaging of brain responses to pain. A review and meta-analysis (2000)
2000 • 2,144 citations
A Three-Dimensional Statistical Analysis for CBF Activation Studies in Human Brain
1992 • 2,062 citations
Nonlinear spatial normalization using basis functions
1999 • 1,860 citations
A potent and selective endogenous agonist for the µ-opiate receptor
1997 • 1,306 citations
Opioid-receptor mRNA expression in the rat CNS: anatomical and functional implications
1995 • 1,267 citations
Peripheral and spinal mechanisms of nociception.
1987 • 1,025 citations
Imaging Synaptic Neurotransmission within VivoBinding Competition Techniques: A Critical Review
2000 • 938 citations
Neuropharmacological Dissection of Placebo Analgesia: Expectation-Activated Opioid Systems versus Conditioning-Activated Specific Subsystems
1999 • 863 citations
Regional Mu Opioid Receptor Regulation of Sensory and Affective Dimensions of Pain
2001 • 832 citations
Neurotransmitter receptor binding
1978 • 822 citations
Distributed processing of pain and vibration by the human brain
1994 • 807 citations
Analgesia from Electrical Stimulation in the Brainstem of the Rat
1971 • 751 citations
Pain Relief by Electrical Stimulation of the Central Gray Matter in Humans and Its Reversal by Naloxone
1977 • 740 citations
A thalamic nucleus specific for pain and temperature sensation
1994 • 588 citations
Ratio scales of sensory and affective verbal pain descriptors
1978 • 558 citations
Cortical and subcortical localization of response to pain in man using positron emission tomography
1991 • 545 citations
Analgesia induced in vivo by central administration of enkephalin in rat
1976 • 524 citations
Opiate receptor knockout mice define μ receptor roles in endogenous nociceptive responses and morphine-induced analgesia
1997 • 511 citations
Positron emission tomographic analysis of cerebral structures activated specifically by repetitive noxious heat stimuli
1994 • 500 citations
Neural activation during acute capsaicin-evoked pain and allodynia assessed with PET
1998 • 393 citations
Broca's region subserves imagery of motion: A combined cytoarchitectonic and fMRI study
2000 • 388 citations
Somatotopic Activation of Opioid Systems by Target-Directed Expectations of Analgesia
1999 • 350 citations
Gender and Age Influences on Human Brain Mu-Opioid Receptor Binding Measured by PET
1999 • 332 citations
mu-Opioid receptor internalization: opiate drugs have differential effects on a conserved endocytic mechanism in vitro and in the mammalian brain.
1998 • 323 citations
Differential distribution of endomorphin 1‐ and endomorphin 2‐like immunoreactivities in the CNS of the rodent
1999 • 277 citations
μ-Opioid Receptor Internalization: Opiate Drugs Have Differential Effects on a Conserved Endocytic MechanismIn Vitroand in the Mammalian Brain
1998 • 265 citations
Increased mu opioid receptor binding detected by PET in cocaine–dependent men is associated with cocaine craving
1996 • 263 citations
Imaging Opiate Receptors in the Human Brain by Positron Tomography
1985 • 256 citations
Differential distribution of endomorphin 1- and endomorphin 2-like immunoreactivities in the CNS of the rodent
1999 • 247 citations
Mu‐opiate receptors measured by positron emission tomography are increased in temporal lobe epilepsy
1988 • 227 citations
Neuropeptides: Regulators of Physiological Processes
1999 • 221 citations
Single-unit analysis of the human ventral thalamic nuclear group: somatosensory responses
1988 • 219 citations
Cytoarchitectonic and immunohistochemical characterization of a specific pain and temperature relay, the posterior portion of the ventral medial nucleus, in the human thalamus
2000 • 204 citations
Multicompartmental Analysis of [11C]-Carfentanil Binding to Opiate Receptors in Humans Measured by Positron Emission Tomography
1989 • 194 citations
Assessment of Spatial Normalization of PET Ligand Images Using Ligand-Specific Templates
1999 • 172 citations
Factors governing release of methionine enkephalin-like immunoreactivity from mesencephalon and spinal cord of the cat in vivo.
1981 • 170 citations
Quantification of mu and non–mu opiate receptors in temporal lobe epilepsy using positron emission tomography
1991 • 169 citations
An autoradiographic map of (3H) diprenorphine binding in rat brain: Effects of social interaction
1981 • 161 citations
CHANGES IN CENTRAL OPIOID RECEPTOR BINDING IN RELATION TO INFLAMMATION AND PAIN IN PATIENTS WITH RHEUMATOID ARTHRITIS
1994 • 160 citations
Radiosynthesis of an opiate receptor binding radiotracer: [11C]carfentanil
1985 • 149 citations
Dissociation of supraspinal and spinal actions of morphine: A quantitative evaluation
1980 • 115 citations
Measurement of Changes in Opioid Receptor Binding in Vivo During Trigeminal Neuralgic Pain Using [11C]Diprenorphine and Positron Emission Tomography
1999 • 104 citations
Imaging of δ‐ and μ‐opioid receptors in temporal lobe epilepsy by positron emission tomography
1997 • 104 citations
In vivo autoradiography: Visualization of stress-induced changes in opiate receptor occupancy in the rat brain
1984 • 99 citations
The Posterior Thalamic Region in Man
1966 • 99 citations
Endogenous opiates: 1998☆
1999 • 90 citations
Action at the mu receptor is sufficient to explain the supraspinal analgesic effect of opiates
1988 • 90 citations
FUNCTIONAL MAGNETIC RESONANCE IMAGING OF THE HUMAN MOTOR CORTEX BEFORE AND AFTER WHOLE-HAND AFFERENT ELECTRICAL STIMULATION
1999 • 69 citations
Global Cerebral Blood Flow Decreases during Pain
1998 • 68 citations
Investigation of the opioid system in absence seizures with positron emission tomography.
1993 • 67 citations
In vivo imaging of neuromodulation using positron emission tomography: Optimal ligand characteristics and task length for detection of activation
1995 • 65 citations
Naloxone increases pain induced by topical capsaicin in healthy human volunteers
2002 • 64 citations
Anatomical Localization for PET Using MR Imaging
1990 • 61 citations
In vivo opioid receptor occupation in the rat brain following exercise.
1986 • 49 citations
In vivo opioid receptor occupation in the rat brain following exercise
1986 • 45 citations
Use of μ and δ opioid peptides of various selectivity gives further evidence of specific involvement of μ opioid receptors in supraspinal analgesia (tail-flick test)
1987 • 41 citations
Endogenous opiate response to pain in rheumatoid arthritis and cortical and subcortical response to pain in normal volunteers using positron emission tomography.
1991 • 35 citations
Independent component-cross correlation-sequential epoch (ICS) analysis of high field fMRI time series: direct visualization of dual representation of the primary motor cortex in human
2000 • 35 citations
Morphine applied to the thalamic nucleus submedius produces a naloxone reversible antinociceptive effect in the rat
1999 • 32 citations
Cutaneous injection of the capsaicin analogue, NE-21610, produces analgesia to heat but not to mechanical stimuli in man
1995 • 28 citations
Effect of Fentanyl and Naloxone on a Thalamic Induced Painful Response in Intractable Epileptic Patients
1998 • 17 citations