The cooperative effects of TNF-α and IFN-γ are determining factors in the ability of IL-10 to protect mice from lethal endotoxemia

Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes.

1991 • 3,812 citations

IL-10 inhibits cytokine production by activated macrophages.

1991 • 2,919 citations

Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones.

1989 • 2,771 citations

IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells.

1991 • 1,880 citations

Interleukin 10 reduces the release of tumor necrosis factor and prevents lethality in experimental endotoxemia.

1993 • 821 citations

Interleukin 10 protects mice from lethal endotoxemia.

1993 • 807 citations

Ly‐1 B (B‐1) cells are the main source of B cell‐derived interleukin 10

1992 • 525 citations

IL-10 is produced by subsets of human CD4+ T cell clones and peripheral blood T cells.

1992 • 417 citations

Generation and characterization of hamster monoclonal antibodies that neutralize murine tumor necrosis factors.

1989 • 385 citations

Anti-IL-6 monoclonal antibodies protect against lethal Escherichia coli infection and lethal tumor necrosis factor-alpha challenge in mice.

1990 • 343 citations

Identification and induction of keratinocyte-derived IL-10.

1992 • 342 citations

Evidence for IFN-gamma as a mediator of the lethality of endotoxin and tumor necrosis factor-alpha.

1992 • 300 citations

Monoclonal antibodies to murine gamma-interferon which differentially modulate macrophage activation and antiviral activity.

1985 • 286 citations

Monoclonal antibodies to murine IL-1 alpha. Production, characterization, and inhibition of membrane-associated IL-1 activity.

1988 • 55 citations