Intragenic regions of the murinePgk-1 locus enhance integration of transfected DNAs into genomes of embryonal carcinoma cells

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Molecular Cloning. A Laboratory Manual

1983 • 27,328 citations

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

Purification of Mouse Immunoglobulin Heavy‐Chain Messenger RNAs from Total Myeloma Tumor RNA

1980 • 2,696 citations

Position-independent, high-level expression of the human β-globin gene in transgenic mice

1987 • 1,955 citations

Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells

1979 • 1,830 citations

Elevated recombination rates in transcriptionally active DNA

1989 • 1,666 citations

Transformation of mammalian cells with genes from procaryotes and eucaryotes

1979 • 1,474 citations

The Rous sarcoma virus long terminal repeat is a strong promoter when introduced into a variety of eukaryotic cells by DNA-mediated transfection.

1982 • 1,371 citations

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

1992 • 1,358 citations

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles

1992 • 1,117 citations

Teratocarcinomas and embryonic stem cells : a practical approach

1987 • 878 citations

Teratocarcinomas and embryonic stem cells: A practical approach

1987 • 768 citations

New type of POU domain in germ line-specific protein Oct-4

1990 • 753 citations

A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells

1990 • 745 citations

A nuclear DNA attachment element mediates elevated and position-independent gene activity

1989 • 597 citations

Isolation of male embryonal carcinoma cells and their chromosome replication patterns

1982 • 422 citations

Evolution of the Functional Human β-Actin Gene and Its Multi-Pseudogene Family: Conservation of Noncoding Regions and Chromosomal Dispersion of Pseudogenes

1985 • 378 citations

Cloning and expression of the mouse pgk-1 gene and the nucleotide sequence of its promoter

1987 • 361 citations

Molecular cloning and characterization of PEA3, a new member of the Ets oncogene family that is differentially expressed in mouse embryonic cells.

1992 • 338 citations

EUKARYOTIC DNA REPLICATION: Anatomy of An Origin

1993 • 280 citations

Mechanisms of DNA uptake by mammalian cells: fate of exogenously added DNA monitored by the use of fluorescent dyes.

1982 • 229 citations

Distal regulatory elements from the mouse metallothionein locus stimulate gene expression in transgenic mice.

1993 • 214 citations

Evolution of the functional human beta-actin gene and its multi-pseudogene family: conservation of noncoding regions and chromosomal dispersion of pseudogenes.

1985 • 211 citations

Bacterial beta-galactosidase as a marker of Rous sarcoma virus gene expression and replication.

1985 • 206 citations

The mouse Pgk-1 gene promoter contains an upstream activator sequence

1991 • 200 citations

Expression in mammalian cells of a gene fromStreptomyces albonigerconferring puromycin resistance

1986 • 183 citations

Muscle-specific expression of the troponin I gene requires interactions between helix-loop-helix muscle regulatory factors and ubiquitous transcription factors.

1991 • 171 citations

Dominant Positive and Negative Selection Using a Hygromycin Phosphotransferase-Thymidine Kinase Fusion Gene

1991 • 167 citations

Autonomous DNA replication in human cells is affected by the size and the source of the DNA.

1991 • 143 citations

Replication initiates at multiple locations on an autonomously replicating plasmid in human cells.

1991 • 133 citations

Transcription enhances intrachromosomal homologous recombination in mammalian cells.

1992 • 132 citations

Evidence for a complex regulatory array in the first intron of the human adenosine deaminase gene.

1989 • 124 citations

A major thyroid hormone response element in the third intron of the rat growth hormone gene.

1990 • 123 citations

Autonomous replication of a DNA fragment containing the chromosomal replication origin of the human c-myc gene

1990 • 120 citations

Structure of the human phosphoglycerate kinase gene and the intron-mediated evolution and dispersal of the nucleotide-binding domain.

1985 • 116 citations

Dominant positive and negative selection using a hygromycin phosphotransferase-thymidine kinase fusion gene.

1991 • 113 citations

Molecular cloning and characterization of mutant and wild-type human beta-actin genes.

1984 • 108 citations

Functional analysis of the human adenosine deaminase gene thymic regulatory region and its ability to generate position-independent transgene expression.

1992 • 108 citations

A COMPARATIVE STUDY OF A SERIES OF NEW INDOLYL COMPOUNDS TO LOCALIZE BETA-GALACTOSIDASE IN TISSUES.

1963 • 103 citations

Regulatory elements in the introns of the human HPRT gene are necessary for its expression in embryonic stem cells.

1990 • 103 citations

Polymorphisms in the coding and noncoding regions of murinePgk-1 alleles

1990 • 95 citations

Differences between rodent and human cell lines in the amount of integrated DNA after transfection*1

1987 • 92 citations

Importance of introns in the growth regulation of mRNA levels of the proliferating cell nuclear antigen gene.

1990 • 87 citations

Autonomous Replication in Human Cells of Multimers of Specific Human and Bacterial DNA Sequences

1993 • 87 citations

Multiple CArG boxes in the human cardiac actin gene promoter required for expression in embryonic cardiac muscle cells developing in vitro from embryonal carcinoma cells.

1991 • 81 citations

Characterization and expression of a murine gene homologous to human EPA/TIMP: a virus-induced gene in the mouse.

1987 • 79 citations

Genetic activity of X chromosomes in pluripotent female teratocarcinoma cells and their differentiated progeny

1980 • 77 citations

Regulated expression of the retinoblastoma gene in differentiating embryonal carcinoma cells.

1993 • 76 citations

Transcription-dependent recombination induced by triple-helix formation.

1993 • 76 citations

Murine PGK‐1 promoter drives widespread but not uniform expression in transgenic mice

1994 • 59 citations

Classes of autonomously replicating sequences are found among early-replicating monkey DNA

1991 • 51 citations

The family of mouse phosphoglycerate kinase genes and pseudogenes

1988 • 49 citations

Transcription-driven site-specific DNA recombination in vitro.

1993 • 49 citations

Stable transformation of a mosquito cell line results in extraordinarily high copy numbers of the plasmid.

1992 • 46 citations

Autonomous replication in human cells of multimers of specific human and bacterial DNA sequences.

1993 • 44 citations

The nucleotide sequence of a cDNA clone containing the entire coding region for mouse X-chromo- some-linked phosphoglycerate kinase

1986 • 44 citations

Introns are essential for growth-regulated expression of the mouse thymidylate synthase gene.

1993 • 37 citations

A common transcriptional activator is located in the coding region of two replication-dependent mouse histone genes.

1991 • 31 citations

Retinoic acid fails to induce expression of Hox genes in differentiation-defective murine embryonal carcinoma cells carrying a mutant gene for alpha retinoic acid receptor

1993 • 25 citations

A genetic element that increases the frequency of gene amplification.

1991 • 19 citations

A possible role for the yeast TATA-element-binding protein in DNA replication.

1993 • 18 citations

Unstable integration of transfected DNAs into embryonal carcinoma cells

1994 • 13 citations