Corticotropin-Releasing Hormone-Mediated Neuroprotection against Oxidative Stress Is Associated with the Increased Release of Non-amyloidogenic Amyloid β Precursor Protein and with the Suppression of Nuclear Factor-κB

THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

1996 • 5,936 citations

Function and Activation of NF-kappaB in the Immune System

1994 • 4,698 citations

Rapid detection of octamer binding proteins with ‘mini extracts’, prepared from a small number of cells

1989 • 4,279 citations

Amyloid plaque core protein in Alzheimer disease and Down syndrome.

1985 • 4,276 citations

Characterization of a 41-Residue Ovine Hypothalamic Peptide that Stimulates Secretion of Corticotropin and β-Endorphin

1982 • 3,896 citations

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

1991 • 3,819 citations

Oxidative Stress, Glutamate, and Neurodegenerative Disorders

1993 • 3,746 citations

An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death

1996 • 3,094 citations

TNF- and Cancer Therapy-Induced Apoptosis: Potentiation by Inhibition of NF-κB

1996 • 2,665 citations

Suppression of TNF-α-Induced Apoptosis by NF-κB

1996 • 2,623 citations

Hydrogen peroxide mediates amyloid β protein toxicity

1994 • 2,065 citations

Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

1996 • 1,962 citations

Amyloid, the presenilins and Alzheimer's disease

1997 • 1,370 citations

Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein

1989 • 1,237 citations

Physiology and pharmacology of corticotropin-releasing factor.

1991 • 1,138 citations

Expression cloning of a human corticotropin-releasing-factor receptor.

1993 • 923 citations

Release of Alzheimer Amyloid Precursor Derivatives Stimulated by Activation of Muscarinic Acetylcholine Receptors

1992 • 899 citations

Antidepressants and Hypothalamic-Pituitary-Adrenocortical Regulation

1996 • 829 citations

Cellular processing of β-amyloid precursor protein and the genesis of amyloid β-peptide

1993 • 809 citations

Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the β-amyloid precursor protein

1993 • 800 citations

Neuroprotection against Oxidative Stress by Estrogens: Structure-Activity Relationship

1997 • 769 citations

Neuroprotection by Aspirin and Sodium Salicylate Through Blockade of NF-κB Activation

1996 • 760 citations

Coupling of a Signal Response Domain in IκBα to Multiple Pathways for NF-κB Activation

1995 • 706 citations

Transcription factor NF-κB is activated in primary neurons by amyloid β peptides and in neurons surrounding early plaques from patients with Alzheimer disease

1997 • 611 citations

Inhibition of NF-kappaB/Rel induces apoptosis of murine B cells.

1996 • 604 citations

Estrogen reduces neuronal generation of Alzheimer β-amyloid peptides

1998 • 545 citations

Analysis and discrimination of necrosis and apoptosis (programmed cell death) by multiparameter flow cytometry

1992 • 542 citations

A Role for 12-lipoxygenase in Nerve Cell Death Caused by Glutathione Depletion

1997 • 495 citations

Secreted form of amyloid β protein precursor is involved in the growth regulation of fibroblasts

1989 • 477 citations

The roles of hydrogen peroxide and superoxide as messengers in the activation of transcription factor NF-κB

1995 • 460 citations

Regulation of Kainate Receptors by cAMP-Dependent Protein Kinase and Phosphatases

1991 • 404 citations

Corticotropin-releasing factor receptors: Physiology, pharmacology, biochemistry and role in central nervous system and immune disorders

1995 • 397 citations

Memory-enhancing effects of secreted forms of the β-amyloid precursor protein in normal and amnestic mice

1998 • 350 citations

Role of cyclic AMP response element-binding protein in cyclic AMP inhibition of NF-kappaB-mediated transcription.

1997 • 320 citations

In vivo and in vitro characterization of antalarmin, a nonpeptide corticotropin-releasing hormone (CRH) receptor antagonist: suppression of pituitary ACTH release and peripheral inflammation.

1996 • 295 citations

Synaptotrophic effects of human amyloid β protein precursors in the cortex of transgenic mice

1994 • 278 citations

Primary Structural Determinants Essential for Potent Inhibition of cAMP-dependent Protein Kinase by Inhibitory Peptides Corresponding to the Active Portion of the Heat-Stable Inhibitor Protein

1989 • 278 citations

Reciprocal changes in corticotropin-releasing factor (CRF)-like immunoreactivity and CRF receptors in cerebral cortex of Alzheimer's disease

1986 • 251 citations

Displacement of corticotropin releasing factor from its binding protein as a possible treatment for Alzheimer's disease

1995 • 229 citations

Cloning and characterization of the human corticotropin-releasing factor-2 receptor complementary deoxyribonucleic acid.

1996 • 228 citations

Homology of the amyloid beta protein precursor in monkey and human supports a primate model for beta amyloidosis in Alzheimer's disease.

1991 • 217 citations

Neurobiology of corticotropin releasing factor (CRF) receptors and CRF-binding protein: implications for the treatment of CNS disorders.

1996 • 187 citations

Janus faces of NF-κB: Neurodestruction versus neuroprotection

1997 • 163 citations

Corticotropin-Releasing Factor-like Immunoreactivity in Senile Dementia of the Alzheimer Type

1985 • 161 citations

Induction of NF-κB Activity during Haloperidol-Induced Oxidative Toxicity in Clonal Hippocampal Cells: Suppression of NF-κB and Neuroprotection by Antioxidants

1998 • 153 citations

Alzheimer's disease: Its proteins and genes

1988 • 149 citations

The expression of amyloid beta protein precursor protects nerve cells from β-amyloid and glutamate toxicity and alters their interaction with the extracellular matrix

1993 • 130 citations

15 Methods for Detecting and Quantifying Apoptosis

1997 • 116 citations

Identification and characterization of a 3',5'-cyclic adenosine monophosphate-responsive element in the human corticotropin-releasing hormone gene promoter.

1992 • 115 citations

Regulation by phorbol esters of amyloid precursor protein release from Swiss 3T3 fibroblasts overexpressing protein kinase C alpha.

1993 • 96 citations

Wild-type but not Alzheimer-mutant amyloid precursor protein confers resistance against p53-mediated apoptosis

1999 • 89 citations

Corticotrophin-releasing factor antagonist inhibits neuronal damage induced by focal cerebral ischaemia or activation of NMDA receptors in the rat brain

1994 • 89 citations

Involvement of hydrogen peroxide and hydroxyl radical in chemically induced apoptosis of HL-60 cells

1999 • 75 citations

Corticotropin releasing factor antagonist reduces ischemic hippocampal neuronal injury

1991 • 73 citations

Melatonin prevents oxidative stress-induced cell death in hippocampal cells

1996 • 71 citations

Transcription factor NF-κB: friend or foe of neurons?

1998 • 69 citations

CSF corticotropin-releasing factor (CRF) in Alzheimer's disease: Its relationship to severity of dementia and monoamine metabolites

1989 • 65 citations

Neuroprotection by corticotropin releasing factor during hypoxia in rat brain.

1993 • 52 citations

Functional corticotropin-releasing factor receptors in human neuroblastoma cells

1996 • 27 citations

Toxicity of ricin and volkensin, two ribosome-inactivating proteins, to microglia, astrocyte, and neuron cultures

1997 • 22 citations

Deleted Work

1955 • 0 citations