Nitric oxide, the endothelium, pregnancy and pre‐eclampsia

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

1980 • 12,033 citations

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

The L-Arginine-Nitric Oxide Pathway

1993 • 6,737 citations

Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.

1987 • 5,027 citations

Vascular endothelial cells synthesize nitric oxide from L-arginine

1988 • 4,800 citations

Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.

1990 • 3,304 citations

Nitric oxide synthases in mammals

1994 • 2,762 citations

Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure

1992 • 2,138 citations

Regulatory Functions of the Vascular Endothelium

1990 • 1,899 citations

Inadequate maternal vascular response to placentation in pregnancies complicated by pre‐eclampsia and by small‐for‐gestational age infants

1986 • 1,618 citations

Nitric oxide activates guanylate cyclase and increases guanosine 3′:5′-cyclic monophosphate levels in various tissue preparations

1977 • 1,422 citations

L-arginine is the physiological precursor for the formation of nitric oxide in endothelium-dependent relaxation

1988 • 1,379 citations

Biosynthesis and Metabolism of Endothelium-Derived Nitric Oxide

1990 • 1,284 citations

Pre-eclampsia: more than pregnancy-induced hypertension

1993 • 1,279 citations

A Study of Angiotensin II Pressor Response throughout Primigravid Pregnancy

1973 • 1,230 citations

Induction of calcium-dependent nitric oxide synthases by sex hormones.

1994 • 1,074 citations

Crucial role of endothelium in the vasodilator response to increased flow in vivo.

1986 • 991 citations

Effect of nitric oxide synthase inhibitors on hypotension in patients with septic shock

1991 • 873 citations

Nitric oxide: mediator, murderer, and medicine

1994 • 836 citations

Cyclic guanosine monophosphate as a mediator of vasodilation.

1986 • 811 citations

Fetal umbilical artery flow velocity waveforms and placental resistance: pathological correlation

1985 • 728 citations

Endothelium and control of vascular function. State of the Art lecture.

1989 • 661 citations

Preeclampsia: An imbalance in placental prostacyclin and thromboxane Production

1985 • 609 citations

Pre-eclampsia and the placenta

1991 • 592 citations

Inflammation: Basic Principles and Clinical Correlates

1993 • 518 citations

Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs ¹

1991 • 461 citations

The pathological response of the vessels of the placental bed to hypertensive pregnancy

1967 • 408 citations

Clinical and Biochemical Evidence of Endothelial Cell Dysfunction in the Pregnancy Syndrome Preeclampsia

1991 • 402 citations

Identification of increased nitric oxide biosynthesis during pregnancy in rats

1993 • 394 citations

The role of nitric oxide in the pathogenesis of preeclampsia

1994 • 392 citations

Arginine is a physiological precursor of endothelium-derived nitric oxide

1988 • 392 citations

EPR characterization of molecular targets for NO in mammalian cells and organelles

1993 • 373 citations

Women with Preeclampsia have Higher Plasma Endothelin Levels than Women with Normal Pregnancies

1990 • 344 citations

Prolonged blockade of nitric oxide synthesis in gravid rats produces sustained hypertension, proteinuria, thrombocytopenia, and intrauterine growth retardation

1994 • 323 citations

Estrogen-induced uterine vasodilatation is antagonized by L-nitroarginine methyl ester, an inhibitor of nitric oxide synthesis

1992 • 312 citations

Oxygen tension regulates the nitric oxide pathway. Physiological role in penile erection.

1993 • 294 citations

Preeclampsia is associated with a serum factor cytotoxic to human endothelial cells

1988 • 290 citations

Early platelet consumption in pre-eclampsia.

1978 • 271 citations

Flow velocity waveforms in the maternal uteroplacental and fetal umbilical placental circulations

1985 • 260 citations

An ultrastructural and ultrahistochemical study of the human placenta in maternal pre-eclampsia

1980 • 234 citations

Cardioprotection and attenuation of endothelial dysfunction by organic nitric oxide donors in myocardial ischemia-reperfusion.

1992 • 234 citations

The effect of placental syncytiotrophoblast microvillous membranes from normal and pre‐eclamptic women on the growth of endothelial cells in vitro

1993 • 232 citations

Involvement of a nitric oxide-cyclic guanosine monophosphate pathway in control of human uterine contractility during pregnancy

1995 • 229 citations

Pathophysiology of pre-eclampsia

2006 • 226 citations

The action of nitric oxide in the perfused human fetal-placental circulation

1991 • 223 citations

Neutrophil‐mediated Vascular Injury

1987 • 217 citations

Arrest of preterm labour and prolongation of gestation with glyceryl trinitrate, a nitric oxide donor

1994 • 216 citations

Immunohistochemical localization of nitric oxide synthase in the human placenta

1993 • 205 citations

Thromboxane A2 synthesis in pregnancy-induced hypertension

1990 • 204 citations

Maternal plasma level of endothelin is increased in preeclampsia

1991 • 203 citations

Attenuation of the vasoconstrictor effects of thromboxane and endothelin by nitric oxide in the human fetal-placental circulation

1992 • 200 citations

Endothelial dysfunction in mesenteric resistance arteries of diabetic rats: role of free radicals

1994 • 198 citations

Trophoblast deportation in pre‐eclamptic pregnancy

1991 • 193 citations

An L-arginine–nitric oxide–cyclic guanosine monophosphate system exists in the uterus and inhibits contractility during pregnancy

1994 • 190 citations

Endothelial-derived relaxing factor released by endothelial cells of human umbilical vessels and its impairment in pregnancy-induced hypertension

1991 • 189 citations

Nω-Nitro-L-arginine, an inhibitor of nitric oxide synthesis, increases blood pressure in rats and reverses the pregnancy-induced refractoriness to vasopressor agents

1992 • 187 citations

Haemostatic, fibrinolytic and endothelial variables in normal pregnancies and pre‐eclampsia

1994 • 187 citations

Nitric oxide inhibits uterine contractility during pregnancy but not during delivery.

1993 • 170 citations

Nitric oxide synthase activity in pregnant rabbit uterus decreases on the last day of pregnancy

1993 • 167 citations

Increased plasma levels of ED1+ cellular fibronectin precede the clinical signs of preeclampsia

1990 • 166 citations

Effects of S-nitroso-glutathione in the human forearm circulation: evidence for selective inhibition of platelet activation

1994 • 166 citations

L-arginine normalizes endothelial function in cerebral vessels from hypercholesterolemic rabbits.

1991 • 165 citations

St Cyres lecture. Endothelium in control.

1991 • 164 citations

Platelets in pregnancy: hyperdestruction in pregnancy.

1983 • 157 citations

Effect of Prostaglandin Synthetase Inhibitors on Pressor Response to Angiotensin II in Human Pregnancy*

1978 • 156 citations

<scp>l</scp>-Arginine Increases Exhaled Nitric Oxide in Normal Human Subjects

1995 • 154 citations

Nitric Oxide Synthase Activity in the Pregnant Uterus Decreases at Parturition

1993 • 151 citations

Gestational changes in l-arginine-induced relaxation of pregnant rat and human myometrial smooth muscle

1993 • 150 citations

Umbilical artery flow velocity waveforms and the placental vascular bed

1987 • 145 citations

Fortnightly Review Biology and clinical relevance of nitric oxide

1994 • 145 citations

Expression of nitric oxide synthase by syncytiotrophoblast in human placental villi

1993 • 142 citations

Evidence against the hypothesis that prostaglandins are the vasodepressor agents of pregnancy. Serial studies in chronically instrumented, conscious rats.

1986 • 141 citations

Prolonged blockade of nitric oxide synthesis in gravid rats produces sustained hypertension, proteinuria, thrombocytopenia, and intrauterine growth retardation

1994 • 137 citations

Ultrastructural aspects of preeclampsia

1989 • 136 citations

The Renin-Angiotensin-Aldosterone System in Preeclampsia

1991 • 133 citations

Plasma level, urinary excretion, and metabolic production of cGMP during gestation in rats

1989 • 125 citations

Endothelial nitric oxide synthase in the human placenta: Regional distribution and proposed regulatory role at the feto-maternal interface☆

1994 • 124 citations

A nitric oxide donor improves uterine artery diastolic blood flow in normal early pregnancy and in women at high risk of pre‐eclampsia

1994 • 122 citations

Constitutive calcium-dependent isoform of nitric oxide synthase in the human placental villous vascular tree

1993 • 120 citations

In vitro release of endothelium-derived relaxing factor by acetylcholine is increased during the guinea pig pregnancy

1989 • 119 citations

Hypoxia-induced fetoplacental vasoconstriction in perfused human placental cotyledons

1987 • 110 citations

The superoxide generation of neutrophils in normal and preeclamptic pregnancies.

1993 • 110 citations

Nitric oxide synthase activities in placental tissue from normotensive, pre‐eclamptic and growth retarded pregnancies

1995 • 109 citations

ABNORMAL PLATELET FUNCTION IN PRE‐ECLAMPSIA

1978 • 106 citations

Obstetrics and Gynecology Annual

1972 • 106 citations

Endothelial vasoactive mediators in preeclampsia

1993 • 104 citations

Two dilatory mechanisms of anti-anginal drugs on epicardial coronary arteries in vivo: indirect, flow-dependent, endothelium-mediated dilation and direct smooth muscle relaxation.

1983 • 103 citations

Purification and Characterization of the Constitutive Nitric-Oxide Synthase from Human Placenta

1994 • 103 citations

Anti-vascular endothelial cell antibodies in severe preeclampsia

1990 • 103 citations

Increased intravascular coagulation associated with pregnancy.

1990 • 93 citations

Platelet-poor plasma serotonin in normal and preeclamptic pregnancy

1993 • 91 citations

Pathogenesis of Preeclampsia

1992 • 90 citations

The endothelium. Target and promoter of hypertension?

1990 • 89 citations

Platelet activation and vascular damage in gestational hypertension

1992 • 87 citations

Mechanisms of vasodilatation in pregnancy: studies of the role of prostaglandins and nitric‐oxide in changes of vascular reactivity in the in situ blood perfused mesentery of pregnant rats

1993 • 86 citations

Elevated circulating thrombomodulin in severe preeclampsia

1993 • 78 citations

Predictive value of fibronectin levels in normotensive gravid women destined to become preeclamptic

1986 • 78 citations

Effect of endothelium-derived relaxing factor inhibition on theumbilical-placental circulation in fetal lambs in utero

1992 • 76 citations

Relationship Between Nitric Oxide Synthesis and Increase in Systolic Blood Pressure in Women with Hypertension in Pregnancy

1993 • 74 citations

Low-dose aspirin

1990 • 74 citations

Cardiovascular alterations in severe pregnancy-induced hypertension: Effects of intravenous nitroglycerin coupled with blood volume expansion

1986 • 72 citations

Enhanced endothelium-derived relaxing factor activity in pregnant, spontaneously hypertensive rats

1991 • 72 citations

Nitric oxide inhibits uterine contractility during pregnancy but not during delivery

1993 • 71 citations

Increased plasma levels of the novel vasoconstrictor peptide endothelin in severe pre-eclampsia

1991 • 71 citations

Placental-type plasminogen activator inhibitor in preeclampsia

1988 • 68 citations

Neutrophil activation is confined to the maternal circulation in pregnancy‐induced hypertension

1992 • 67 citations

Immunocytochemical localization of neutrophil elastase in term placenta decidua and myometrium in pregnancy‐induced hypertension

1991 • 67 citations

Increased Intravascular Coagulation Associated With Pregnancy

1991 • 60 citations

Doppler echocardiographic assessment of fetal descending aortic and umbilical blood flows. Validation studies in fetal lambs.

1991 • 59 citations

Endothelial cell activation as a pathogenetic factor in preeclampsia.

1991 • 59 citations

Effects of Nitroglycerin and Nitroprusside on the Uterine Vasculature of Gravid Ewes

1980 • 57 citations

Electrophoresis of Human Gastric Juice in Relation to Castle's Intrinsic Factor

1953 • 55 citations

Ultrastructural aspects of preeclampsia

1990 • 51 citations

NO is more important than PGI2 in maintaining low vascular tone in feto-placental vessels

1993 • 51 citations

The renin-angiotensin-aldosterone system in preeclampsia. A review.

1991 • 49 citations

Pathogenesis of Preeclampsia

1992 • 43 citations

Endothelium-derived relaxing factor and cyclic GMP-dependent vasorelaxation in human chorionic plate arteries

1994 • 40 citations

Endomyocardial ultrastructural findings in preeclampsia

1991 • 38 citations

Blunted vasoreactivity in pregnant guinea pigs is not restored by meclofenamate

1989 • 37 citations

Interactions between organic nitrates and thiol groups

1991 • 36 citations

Restenosis after Coronary Angioplasty: Pathogenesis of Neointimal Thickening Initiated by Endothelial Loss

1993 • 35 citations

Exhaled nitric oxide concentration and amniotic fluid nitrite concentration during pregnancy

1995 • 34 citations

Sulfhydryl group donors potentiate the hypotensive effect of acetylcholine in rats.

1993 • 31 citations

Nitroprusside in preeclampsia. Circulatory distress and paradoxical bradycardia.

1991 • 30 citations

Doppler ultrasound in perinatal medicine

1993 • 28 citations

The maternal hemodynamic effect of indomethacin in normal pregnancy.

1992 • 27 citations

Evaluation of changes in umbilical blood flow in the fetal lamb by Doppler waveform analysis

1991 • 27 citations

Does the umbilical artery systolic/diastolic ratio reflect flow or acidosis?

1990 • 26 citations

Effects of Nitric Oxide Donors in Vitro on the Arachidonic Acid-Induced Platelet Release Reaction and Platelet Cyclic GMP Concentration in Pre-Eclampsia

1994 • 25 citations

Amino acids, glucose and lactate concentrations in umbilical cord blood in relation to umbilical artery flow patterns

1994 • 24 citations

Endothelins in perinatal biology.

1991 • 24 citations

The hemodynamic effects of intubation during nitroglycerin infusion in severe preeclampsia

1991 • 23 citations

Plasma levels and cardiovascular effects of nitroglycerin in pregnant sheep

1980 • 22 citations

Blood pressure control in pregnant rabbits: norepinephrine and prostaglandin interactions

1984 • 19 citations

Free amino acid concentrations in human first and third trimester placental villi

1994 • 13 citations

Deficiency of c-Gmrp Level in Placental Circulation in Pregnancy-Induced Hypertensive Disorders: Possibility of Decreased Endothelium-Derived Relaxing Factor Activity

1994 • 11 citations

Acute Hypertensive Crisis in Pregnancy

1989 • 11 citations

Fetoplacental circulation in health and disease.

1994 • 10 citations

Management of Severe Pregnancy-Induced Hypertension, or Gestosis, with Sodium Nitroprusside

1990 • 9 citations

Functional properties of small human placental arteries in relation to abnormal umbilical doppler waveform analysis

1993 • 6 citations

Nitric oxide synthase activity in human myometrium

1994 • 5 citations

Nitrates and nitrate tolerance in congestive heart failure

1993 • 4 citations