Inhibitory effects of amiodarone and its N‐deethylated metabolite on human cytochrome P450 activities: Prediction of in vivo drug interactions

P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature

1996 • 2,895 citations

Prediction of pharmacokinetic alterations caused by drug-drug interactions: metabolic interaction in the liver.

1998 • 497 citations

Amiodarone pharmacokinetics

1983 • 397 citations

Clinical Pharmacokinetics of Amiodarone

1984 • 310 citations

Inactivation of Cytochrome P450 3A4 by Bergamottin, a Component of Grapefruit Juice

1998 • 309 citations

Mechanism-based inactivation of human liver microsomal cytochrome P-450 IIIA4 by gestodene

1990 • 281 citations

Isoform-selective mechanism-based inhibition of human cytochrome P450 1A2 by furafylline

1993 • 214 citations

Pharmacokinetics of amiodarone after intravenous and oral administration

1981 • 198 citations

Pharmacokinetic Interactions of Cimetidine 1987

1987 • 195 citations

The mechanism of the interaction between amiodarone and warfarin in humans

1992 • 155 citations

Amiodarone

1992 • 154 citations

[43] Measurement of steroid hydroxylation reactions by high-performance liquid chromatography as indicator of P450 identity and function

1991 • 130 citations

Molecular genetics of the human cytochrome P450 monooxygenase superfamily

1998 • 128 citations

Amiodarone kinetics after oral doses

1982 • 126 citations

Relationships between amiodarone dosage, drug concentrations, and adverse side effects

1983 • 121 citations

Biotransformation of Chlorzoxazone by Heptatic Microsomes from Humans and Ten Other Mammalian Species

1997 • 117 citations

Interaction of amiodarone with racemic warfarin and its separated enantiomorphs in humans

1987 • 114 citations

Effects of erythromycin on hepatic drug-metabolizing enzymes in humans

1983 • 104 citations

Evidence for CYP3A-mediated N-deethylation of amiodarone in human liver microsomal fractions.

1993 • 97 citations

Serum concentrations of amiodarone during long term therapy. Relation to dose, efficacy and toxicity

1983 • 89 citations

Mechanism-based inactivation of cytochrome P-450-3A4 by mifepristone (RU486).

1999 • 87 citations

Adverse Effects of Amiodarone

1998 • 85 citations

Variable disposition kinetics and electrocardiographic effects of flecainide during repeated dosing in humans: Contribution of genetic factors, dose-dependent clearance, and interaction with amiodarone

1994 • 76 citations

Cytochrome P450 2C9 catalyzes indomethacin O-demethylation in human liver microsomes.

1998 • 74 citations

Involvement of CYP1A2 in mexiletine metabolism

1998 • 67 citations

Binding of amiodarone by serum proteins and the effects of drugs, hormones and other interacting ligands

1984 • 63 citations

Inhibitory effects of antiarrhythmic drugs on phenacetin O‐deethylation catalysed by human CYP1A2

1998 • 62 citations

Highly sensitive high-performance liquid chromatographic assay for coumarin 7-hydroxylation and 7-ethoxycoumarin O-deethylation by human liver cytochrome P450 enzymes

1999 • 59 citations

Amiodarone N-deethylation in human liver microsomes : Involvement of cytochrome P450 3A enzymes (first report)

1993 • 58 citations

(R)-(+)-Menthofuran is a potent, mechanism-based inactivator of human liver cytochrome P450 2A6.

1998 • 56 citations

Potent and selective inactivation of human liver microsomal cytochrome P-450 isoforms by L-754,394, an investigational human immune deficiency virus protease inhibitor.

1995 • 56 citations

Highly sensitive and specific high-performance liquid chromatographic analysis of 7-hydroxywarfarin, a marker for human cytochrome P-4502C9 activity

1995 • 47 citations

Cyclosporine-Amiodarone Interaction

1993 • 42 citations

Significance of metabolism in the disposition and action of the antidysrhythmic drug, dofetilide. In vitro studies and correlation with in vivo data.

1996 • 41 citations

Amiodarone-cyclosporine interaction in a heart transplant patient.

1992 • 41 citations

Effects of clarithromycin and its metabolites on the mixed function oxidase system in hepatic microsomes of rats.

1993 • 40 citations

Pharmacokinetic interaction between intravenous phenytoin and amiodarone in healthy volunteers

1989 • 36 citations

Formation of an inactive cytochrome P-450Fe(II)-metabolite complex after administration of amiodarone in rats, mice and hamsters

1986 • 33 citations

Pharmacokinetics of amiodarone, desethylamiodarone and other iodine-containing amiodarone metabolites

1985 • 25 citations

Influence of amiodarone on genetically determined drug metabolism in humans

1991 • 22 citations

Amiodarone and desethylamiodarone elimination kinetics following withdrawal of long‐term amiodarone maintenance therapy

1985 • 19 citations

Inhibitory effects of antiarrhythmic drugs on phenacetin O-deethylation catalysed by human CYP1A2

1998 • 10 citations

The inhibitory effect of amiodarone and desethylamiodarone on dextromethorphan O-demethylation in human and rat liver microsomes

1994 • 8 citations