Regulation of inositol 1,4,5-trisphosphate kinase activity after stimulation of human T cell antigen receptor.

Calcium's Role in Mechanotransduction during Muscle Development

2014 • 14,293 citations

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

Studies and Perspectives of Protein Kinase C

1986 • 5,148 citations

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

Phorbol diester receptor copurifies with protein kinase C.

1983 • 1,185 citations

Transmembrane signalling by the T cell antigen receptor. Perturbation of the T3-antigen receptor complex generates inositol phosphates and releases calcium ions from intracellular stores.

1985 • 742 citations

The inositol tris/tetrakisphosphate pathway—demonstration of Ins(l,4,5)P3 3-kinase activity in animal tissues

1986 • 702 citations

The inositol trisphosphate phosphomonoesterase of the human erythrocyte membrane

1982 • 541 citations

Requirement for the coexpression of T3 and the T cell antigen receptor on a malignant human T cell line.

1984 • 504 citations

Role of T3 surface molecules in human T-cell activation: T3-dependent activation results in an increase in cytoplasmic free calcium.

1984 • 452 citations

Metabolism of inositol 1,4,5-trisphosphate and inositol 1,3,4-trisphosphate in rat parotid glands

1985 • 450 citations

Antigen-like effects of monoclonal antibodies directed at receptors on human T cell clones.

1983 • 435 citations

Protein kinase C phosphorylates human platelet inositol trisphosphate 5′-phosphomonoesterase, increasing the phosphatase activity

1986 • 354 citations

Stimulation of the T3-T cell receptor complex induces a membrane-potential-sensitive calcium influx

1985 • 282 citations

Formation and metabolism of inositol 1,3,4,5-tetrakisphosphate in liver.

1986 • 280 citations

The Human T-Cell Receptor

1984 • 232 citations

The antigen receptor on a human T cell line initiates activation by increasing cytoplasmic free calcium.

1985 • 223 citations

Cholera toxin inhibits the T-cell antigen receptor-mediated increases in inositol trisphosphate and cytoplasmic free calcium.

1986 • 202 citations

Ligand-receptor interactions required for commitment to the activation of the interleukin 2 gene.

1987 • 182 citations

Single-channel and whole-cell recordings of mitogen-regulated inward currents in human cloned helper T lymphocytes

1986 • 151 citations

Second messenger function of inositol 1,4,5-trisphosphate. Early changes in inositol phosphates, cytosolic Ca2+, and insulin release in carbamylcholine-stimulated RINm5F cells.

1986 • 149 citations

Valency of CD3 binding and internalization of the CD3 cell-surface complex control T cell responses to second signals: distinction between effects on protein kinase C, cytoplasmic free calcium, and proliferation.

1986 • 139 citations

Interleukin 2-induced lymphocyte proliferation is independent of increases in cytosolic-free calcium concentrations.

1985 • 113 citations

Phorbol 12,13-dibutyrate and 1-oleyl-2-acetyldiacylglycerol stimulate inositol trisphosphate dephosphorylation in human platelets.

1986 • 110 citations

Antigen-dependent increase in cytosolic free calcium in specific human T-lymphocyte clones

1985 • 92 citations

Antigen-specific T cell activation results in an increase in cytoplasmic free calcium.

1985 • 66 citations

Antigen recognition by a human T cell clone leads to increases in inositol trisphosphate.

1987 • 60 citations

Perturbation of the human T-cell antigen receptor-T3 complex leads to the production of inositol tetrakisphosphate: evidence for conversion from inositol trisphosphate.

1986 • 46 citations