Orthotopic liver transplantation using low-dose tacrolimus and sirolimus

Efficacy of sirolimus compared with azathioprine for reduction of acute renal allograft rejection: a randomised multicentre study

2000 • 922 citations

SIROLIMUS (RAPAMYCIN)-BASED THERAPY IN HUMAN RENAL TRANSPLANTATION

1999 • 886 citations

A WORLDWIDE, PHASE III, RANDOMIZED, CONTROLLED, SAFETY AND EFFICACY STUDY OF A SIROLIMUS/CYCLOSPORINE REGIMEN FOR PREVENTION OF ACUTE REJECTION IN RECIPIENTS OF PRIMARY MISMATCHED RENAL ALLOGRAFTS

2001 • 616 citations

The immunosuppressive macrolides FK-506 and rapamycin act as reciprocal antagonists in murine T cells.

1990 • 360 citations

Clinical pharmacokinetics and therapeutic drug monitoring of sirolimus

2000 • 277 citations

A LONG-TERM COMPARISON OF TACROLIMUS (FK506) VERSUS CYCLOSPORINE IN LIVER TRANSPLANTATION1

1998 • 214 citations

SIROLIMUS: A POTENT NEW IMMUNOSUPPRESSANT FOR LIVER TRANSPLANTATION

1999 • 207 citations

Evolution of cardiovascular risk after liver transplantation: A comparison of cyclosporine A and tacrolimus (FK506)

1997 • 196 citations

The effects of relative timing of sirolimus and cyclosporine microemulsion formulation coadministration on the pharmacokinetics of each agent*

1998 • 125 citations

Rapamycin: A bone sparing immunosuppressant?

1995 • 105 citations

TACROLIMUS (FK506) AND SIROLIMUS (RAPAMYCIN) IN COMBINATION ARE NOT ANTAGONISTIC BUT PRODUCE EXTENDED GRAFT SURVIVAL IN CARDIAC TRANSPLANTATION IN THE RAT1,2

1997 • 101 citations

Experience with the use of sirolimus in liver transplantation—use in patients for whom calcineurin inhibitors are contraindicated

2000 • 77 citations

Use of rapamycin for the suppression of alloimmune reactions in vivo: schedule dependence, tolerance induction, synergy with cyclosporine and FK 506, and effect on host-versus-graft and graft-versus-host reactions.

1991 • 65 citations

EFFECT OF TACROLIMUS (FK506) AND SIROLIMUS (RAPAMYCIN) MONO- AND COMBINATION THERAPY IN PROLONGATION OF RENAL ALLOGRAFT SURVIVAL IN THE MONKEY1

2000 • 65 citations

An immunoassay for the measurement of sirolimus

2000 • 57 citations

Cyclosporin A, FK506, rapamycin

1992 • 26 citations

Analytical Performance of Microparticle Enzyme Immunoassay and HPLC-Tandem Mass Spectrometry in the Determination of Sirolimus in Whole Blood

1999 • 25 citations

SIROLIMUS IMMUNOSUPPRESSION FOR LIVER TRANSPLANTATION IN THE PRESENCE OF MALIGNANCY.

2000 • 3 citations

EARLY STEROID WITHDRAWAL FOLLOWING LIVER TRANSPLANTATION - TWO-YEAR FOLLOW-UP.

2000 • 2 citations