A WORLDWIDE, PHASE III, RANDOMIZED, CONTROLLED, SAFETY AND EFFICACY STUDY OF A SIROLIMUS/CYCLOSPORINE REGIMEN FOR PREVENTION OF ACUTE REJECTION IN RECIPIENTS OF PRIMARY MISMATCHED RENAL ALLOGRAFTS

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

1991 • 4,043 citations

A mammalian protein targeted by G1-arresting rapamycin–receptor complex

1994 • 1,954 citations

Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle.

1975 • 1,605 citations

RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

1994 • 1,470 citations

International standardization of criteria for the histologic diagnosis of renal allograft rejection: The Banff working classification of kidney transplant pathology

1993 • 1,431 citations

MYCOPHENOLATE MOFETIL FOR THE PREVENTION OF ACUTE REJECTION IN PRIMARY CADAVERIC RENAL ALLOGRAFT RECIPIENTS

1995 • 1,380 citations

A COMPARISON OF TACROLIMUS (FK506) AND CYCLOSPORINE FOR IMMUNOSUPPRESSION AFTER CADAVERIC RENAL TRANSPLANTATION1

1997 • 1,128 citations

Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A

1991 • 1,054 citations

PLACEBO-CONTROLLED STUDY OF MYCOPHENOLATE MOFETIL COMBINED WITH CYCLOSPORINE AND CORTICOSTEROIDS FOR PREVENTION OF ACUTE REJECTION

1995 • 985 citations

Increased Incidence of Lymphoproliferative Disorder after Immunosuppression with the Monoclonal Antibody OKT3 in Cardiac-Transplant Recipients

1990 • 947 citations

Efficacy of sirolimus compared with azathioprine for reduction of acute renal allograft rejection: a randomised multicentre study

2000 • 922 citations

Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization.

1975 • 908 citations

SIROLIMUS (RAPAMYCIN)-BASED THERAPY IN HUMAN RENAL TRANSPLANTATION

1999 • 886 citations

Interleukin-2–Receptor Blockade with Daclizumab to Prevent Acute Rejection in Renal Transplantation

1998 • 875 citations

Isolation of a Protein Target of the FKBP12-Rapamycin Complex in Mammalian Cells

1995 • 859 citations

Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A.

1992 • 811 citations

Randomised trial of basiliximab versus placebo for control of acute cellular rejection in renal allograft recipients

1997 • 757 citations

MYCOPHENOLATE MOFETIL IN RENAL ALLOGRAFT RECIPIENTS

1997 • 584 citations

Inhibition of T cell signaling by immunophilin-ligand complexes correlates with loss of calcineurin phosphatase activity

1992 • 561 citations

RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex.

1994 • 475 citations

Beneficial effects of treatment of early subclinical rejection

1998 • 463 citations

THE IMPACT OF AN ACUTE REJECTION EPISODE ON LONG-TERM RENAL ALLOGRAFT SURVIVAL (t1/2)1,2

1994 • 444 citations

EARLY VERSUS LATE ACUTE RENAL ALLOGRAFT REJECTION

1993 • 374 citations

A Randomized Clinical Trial of Cyclosporine in Cadaveric Renal Transplantation

1986 • 295 citations

NF-ATp, a T lymphocyte DNA-binding protein that is a target for calcineurin and immunosuppressive drugs.

1993 • 293 citations

PREDICTING GLOMERULAR FILTRATION RATE AFTER KIDNEY TRANSPLANTATION

1995 • 289 citations

SIROLIMUS REDUCES THE INCIDENCE OF ACUTE REJECTION EPISODES DESPITE LOWER CYCLOSPORINE DOSES IN CAUCASIAN RECIPIENTS OF MISMATCHED PRIMARY RENAL ALLOGRAFTS: A PHASE II TRIAL1

1999 • 279 citations

THE IMPACT OF ACUTE REJECTION EPISODES ON LONG-TERM GRAFT FUNCTION AND OUTCOME IN 1347 PRIMARY RENAL TRANSPLANTS TREATED BY 3 CYCLOSPORINE REGIMENS

1993 • 268 citations

The side effect profile of sirolimus: A phase I study in quiescent cyclosporine-prednisone-treated renal transplant patients

1996 • 267 citations

Peptidylproline cis/trans isomerases

1995 • 235 citations

THE INCIDENCE AND IMPACT OF EARLY REJECTION EPISODES ON GRAFT OUTCOME IN RECIPIENTS OF FIRST CADAVER KIDNEY TRANSPLANTS

1992 • 203 citations

Sequential protocol biopsies in renal transplant patients. Clinico-pathological correlations using the Banff schema.

1995 • 189 citations

IMMUNOSUPPRESSIVE THERAPY IN HIGH-RISK TRANSPLANT PATIENTS

1997 • 187 citations

Causes of Renal Allograft Loss

1991 • 176 citations

SEQUENTIAL PROTOCOL BIOPSIES IN RENAL TRANSPLANT PATIENTS

1995 • 165 citations

HYPERLIPIDEMIA IN RENAL TRANSPLANT RECIPIENTS TREATED WITH SIROLIMUS(RAPAMYCIN)

1998 • 160 citations

Rapamycin blocks cell cycle progression of activated T cells prior to events characteristic of the middle to late G₁ phase of the cycle

1993 • 154 citations

Acute rejection episodes--best predictor of long-term primary cadaveric renal transplant survival.

1994 • 150 citations

DETERMINANTS OF CHRONIC RENAL ALLOGRAFT REJECTION IN CYCLOSPORINE-TREATED RECIPIENTS

1996 • 115 citations

Conversion from cyclosporine to FK 506 in liver allograft recipients with cyclosporine-related complications.

1990 • 108 citations

Synergistic mechanisms by which sirolimus and cyclosporin inhibit rat heart and kidney allograft rejection

1997 • 102 citations

Sirolimus: A new agent for clinical renal transplantation

1997 • 92 citations

PRODUCTION OF SYNERGISTIC BUT NONIDENTICAL MECHANISMS OF IMMUNOSUPPRESSION BY RAPAMYCIN AND CYCLOSPORINE

1991 • 88 citations

An analysis of predictors of long‐term cadaveric renal allograft survival

1995 • 80 citations

A Putative Sirolimus (Rapamycin) Effector Protein

1994 • 77 citations

Severe Neurologic Toxicity Induced by Cyclosporine A in Three Renal Transplant Patients

1991 • 74 citations

Rapamycin (sirolimus, rapamune)

1995 • 69 citations

Nephrotoxicity of Cyclosporin A and FK506: Inhibition of Calcineurin Phosphatase

1995 • 45 citations

ANALYSIS OF THE INTERACTIONS OF IMMUNOSUPPRESSIVE DRUGS WITH CYCLOSPORINE IN INHIBITING DNA PROLIFERATION

1990 • 43 citations

The immunophilins

1994 • 38 citations

Early rejection: determining the fate of renal transplants.

1991 • 33 citations

Conversion of liver allograft recipients with cyclosporine related complications from cyclosporine to FK 506

1990 • 32 citations

Epstein-Barr virus DNA in serum after liver transplantation ? surveillance of viral activity during treatment with different immunosuppressive agents

1996 • 29 citations

Causes of renal allograft loss in black vs. white transplant recipients in the cyclosporine era

1997 • 29 citations

Synergistic effect of the rapamycin-cyclosporine combination: median effect analysis of in vitro immune performances by human T lymphocytes in PHA, CD3, and MLR proliferative and cytotoxicity assays.

1991 • 22 citations

A randomized multicenter trial of cyclosporin and prednisolone versus cyclosporin, azathioprine, and prednisolone following primary living donor renal transplantation

1994 • 8 citations

A randomized multicenter trial of cyclosporin and prednisolone versus cyclosporin, azathioprine, and prednisolone following primary living donor renal transplantation

1994 • 6 citations

Deleted Work

1955 • 0 citations