SIROLIMUS: A POTENT NEW IMMUNOSUPPRESSANT FOR LIVER TRANSPLANTATION

A mammalian protein targeted by G1-arresting rapamycin–receptor complex

1994 • 1,954 citations

RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

1994 • 1,470 citations

Isolation of a Protein Target of the FKBP12-Rapamycin Complex in Mammalian Cells

1995 • 859 citations

Rapamycin-Induced Inhibition of the 70-Kilodalton S6 Protein Kinase

1992 • 666 citations

Medicine and the Law

1987 • 541 citations

The side effect profile of sirolimus: A phase I study in quiescent cyclosporine-prednisone-treated renal transplant patients

1996 • 267 citations

Immunophilins in protein folding and immunosuppression ¹

1994 • 247 citations

Rapamycin: A novel immunosuppressive macrolide

1994 • 166 citations

Interaction between FKBP12-rapamycin and TOR involves a conserved serine residue.

1994 • 143 citations

PRODUCTION OF SYNERGISTIC BUT NONIDENTICAL MECHANISMS OF IMMUNOSUPPRESSION BY RAPAMYCIN AND CYCLOSPORINE

1991 • 88 citations

Studies in experimental models of chronic rejection: use of rapamycin (sirolimus) and isoxazole derivatives (leflunomide and its analogue) for the suppression of graft vascular disease and obliterative bronchiolitis.

1995 • 60 citations

Low-dose rapamycin potentiates the effects of subtherapeutic doses of cyclosporine to prolong renal allograft survival in the mongrel canine model.

1993 • 50 citations

Rapamycin in experimental renal allografts in dogs and pigs.

1990 • 45 citations

Cross‐linking CD28 leads to activation of 70‐kDa S6 kinase

1994 • 37 citations

BRIEF COMMUNICATION

1993 • 31 citations

Rapamycin in experimental renal allografts in primates.

1991 • 27 citations

Synergistic effect of the rapamycin-cyclosporine combination: median effect analysis of in vitro immune performances by human T lymphocytes in PHA, CD3, and MLR proliferative and cytotoxicity assays.

1991 • 22 citations