Chronic Low Back Pain and Meditation

NCT04034004

EARLY_PHASE1INTERVENTIONAL

University of California, San Diego

88 participants

Started 2021-01-01 · Completed 2022-12-22

Status: Completed (as of 12-23-2025)

Conditions

Pain

Interventions

BEHAVIORAL: Mindfulness DRUG: Naloxone OTHER: Saline BEHAVIORAL: Meditation

Linked Papers (from SciSciNet-V2)

Total Papers51

Background

24

Result

0

Derived

0

Unknown

27

View on ClinicalTrials.gov

Total Citations Per Year

Brief Summary

The purpose of this research study is to see if and how mindfulness meditation affects pain. Specifically, we are interested in assessing if mindfulness is associated with the release of naturally occurring opiates in the body, in response to intravenous (IV) administration of the opioid antagonist naloxone during a chronic low back pain provoking procedure.

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Background Papers48

Overtreating Chronic Back Pain: Time to Back Off?

Overtreating Chronic Back Pain: Time to Back Off?

Brain Mechanisms Supporting the Modulation of Pain by Mindfulness Meditation

Brain Mechanisms Supporting the Modulation of Pain by Mindfulness Meditation

Decreased Central μ-Opioid Receptor Availability in Fibromyalgia

Decreased Central μ-Opioid Receptor Availability in Fibromyalgia

μ-Opioid Receptor-Mediated Antinociceptive Responses Differ in Men and Women

μ-Opioid Receptor-Mediated Antinociceptive Responses Differ in Men and Women

Mindfulness Meditation-Based Pain Relief Employs Different Neural Mechanisms Than Placebo and Sham Mindfulness Meditation-Induced Analgesia

Mindfulness Meditation-Based Pain Relief Employs Different Neural Mechanisms Than Placebo and Sham Mindfulness Meditation-Induced Analgesia

The active straight leg raising test and mobility of the pelvic joints

The active straight leg raising test and mobility of the pelvic joints

Default mode network connectivity encodes clinical pain: An arterial spin labeling study

Default mode network connectivity encodes clinical pain: An arterial spin labeling study

The future of pain research, education, and treatment: a summary of the IOM report “Relieving pain in America: a blueprint for transforming prevention, care, education, and research”

The future of pain research, education, and treatment: a summary of the IOM report “Relieving pain in America: a blueprint for transforming prevention, care, education, and research”

Mindfulness meditation-related pain relief: Evidence for unique brain mechanisms in the regulation of pain

Mindfulness meditation-related pain relief: Evidence for unique brain mechanisms in the regulation of pain

Substance misuse treatment for high-risk chronic pain patients on opioid therapy: A randomized trial

Substance misuse treatment for high-risk chronic pain patients on opioid therapy: A randomized trial

Neural correlates of mindfulness meditation-related anxiety relief

Neural correlates of mindfulness meditation-related anxiety relief

Mindfulness-Meditation-Based Pain Relief Is Not Mediated by Endogenous Opioids

Mindfulness-Meditation-Based Pain Relief Is Not Mediated by Endogenous Opioids

Neural Correlates of Chronic Low Back Pain Measured by Arterial Spin Labeling

Neural Correlates of Chronic Low Back Pain Measured by Arterial Spin Labeling

Chronic neuropathic pain reduces opioid receptor availability with associated anhedonia in rat

Chronic neuropathic pain reduces opioid receptor availability with associated anhedonia in rat

Alterations in Endogenous Opioid Functional Measures in Chronic Back Pain

Alterations in Endogenous Opioid Functional Measures in Chronic Back Pain

Reduced Basal Ganglia μ-Opioid Receptor Availability in Trigeminal Neuropathic Pain: A Pilot Study

Reduced Basal Ganglia μ-Opioid Receptor Availability in Trigeminal Neuropathic Pain: A Pilot Study

Trait anger expressiveness and pain-induced beta-endorphin release: Support for the opioid dysfunction hypothesis

Trait anger expressiveness and pain-induced beta-endorphin release: Support for the opioid dysfunction hypothesis

Striatal opioid receptor availability is related to acute and chronic pain perception in arthritis

Striatal opioid receptor availability is related to acute and chronic pain perception in arthritis

Brain mechanisms supporting violated expectations of pain

Brain mechanisms supporting violated expectations of pain

Inter-rater agreement, sensitivity, and specificity of the prone hip extension test and active straight leg raise test

The Contribution of Differential Opioid Responsiveness to Identification of Opioid Risk in Chronic Pain Patients

Enhancement of Meditation Analgesia by Opioid Antagonist in Experienced Meditators

The Contribution of Differential Opioid Responsiveness to Identification of Opioid Risk in Chronic Pain Patients

Enhancement of Meditation Analgesia by Opioid Antagonist in Experienced Meditators

Inter-rater agreement, sensitivity, and specificity of the prone hip extension test and active straight leg raise test

Endogenous Opioid Function and Responses to Morphine: The Moderating Effects of Anger Expressiveness

Endogenous Opioid Function and Responses to Morphine: The Moderating Effects of Anger Expressiveness

fMRI in patients with lumbar disc disease: a paradigm to study patients over time

fMRI in patients with lumbar disc disease: a paradigm to study patients over time

Result Papers0

No result papers linked

Derived Papers0

No derived papers linked

Unknown Papers27

Epidemiological features of chronic low-back pain

3,068 citations

A systematic review of the global prevalence of low back pain

2,627 citations

Mindfulness meditation improves cognition: Evidence of brief mental training

1,170 citations

Regional Mu Opioid Receptor Regulation of Sensory and Affective Dimensions of Pain

Nonmedical Prescription Opioid Use and Use Disorders Among Adults Aged 18 Through 64 Years in the United States, 2003-2013

The Effects of Brief Mindfulness Meditation Training on Experimentally Induced Pain

Effects of Brief and Sham Mindfulness Meditation on Mood and Cardiovascular Variables

Pharmacokinetics of Naloxone in Rats and in Man

Changes in Substance Abuse Treatment Use Among Individuals With Opioid Use Disorders in the United States, 2004-2013

The association between negative affect and opioid analgesia in patients with discogenic low back pain

Differential brain opioid receptor availability in central and peripheral neuropathic pain

CHANGES IN CENTRAL OPIOID RECEPTOR BINDING IN RELATION TO INFLAMMATION AND PAIN IN PATIENTS WITH RHEUMATOID ARTHRITIS

Cerebral decreases in opioid receptor binding in patients with central neuropathic pain measured by [¹¹C]diprenorphine binding and PET

Pain activation of human supraspinal opioid pathways as demonstrated by [11C]-carfentanil and positron emission tomography (PET)

A Systematic Review of the Passive Straight Leg Raising Test as a Diagnostic Aid for Low Back Pain (1989 to 2000)

Measurement of Changes in Opioid Receptor Binding in Vivo During Trigeminal Neuralgic Pain Using [¹¹C]Diprenorphine and Positron Emission Tomography

Low Back Pain: Clinimetric Properties of the Trendelenburg Test, Active Straight Leg Raise Test, and Breathing Pattern During Active Straight Leg Raising

Imaging the pain of low back pain: functional magnetic resonance imaging in combination with monitoring subjective pain perception allows the study of clinical pain states

Central opioidergic neurotransmission in complex regional pain syndrome

Naloxone increases pain induced by topical capsaicin in healthy human volunteers

The association between anger expression and chronic pain intensity: evidence for partial mediation by endogenous opioid dysfunction

Parental history of chronic pain may be associated with impairments in endogenous opioid analgesic systems

Low Back Pain on Passive Straight Leg Raising

As Opioid Prescribing Guidelines Tighten, Mindfulness Meditation Holds Promise for Pain Relief

Inter-rater reliability of the Active Straight-Leg Raise and One-Leg Standing tests in non-pregnant women