Cytoskeletal alterations in cultured cardiomyocytes following exposure to the lipid peroxidation product, 4‐hydroxynonenal

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes

1991 • 6,550 citations

Beyond Cholesterol

1989 • 6,533 citations

Free Radicals in Biology and Medicine

1990 • 4,962 citations

Focal Adhesions: Transmembrane Junctions Between the Extracellular Matrix and the Cytoskeleton

1988 • 2,137 citations

Book ReviewAmbulatory Pediatric Care

1989 • 2,075 citations

Intermediate filaments as mechanical integrators of cellular space

1980 • 1,973 citations

Mechanism of myocardial "stunning".

1990 • 995 citations

Cytotoxicity and genotoxicity of lipid-oxidation products

1993 • 802 citations

Oxygen radical chemistry of polyunsaturated fatty acids

1989 • 716 citations

Measurement of cytosolic free Ca2+ in individual small cells using fluorescence microscopy with dual excitation wavelengths

1985 • 660 citations

Antisera and monoclonal antibodies specific for epitopes generated during oxidative modification of low density lipoprotein.

1990 • 627 citations

Bleb Formation in Hepatocytes During Drug Metabolism Is Caused by Disturbances in Thiol and Calcium Ion Homeostasis

1982 • 553 citations

Impairment of the myocardial ultrastructure and changes of the cytoskeleton in dilated cardiomyopathy.

1991 • 517 citations

Effect of a transient period of ischemia on myocardial cells. II. Fine structure during the first few minutes of reflow.

1974 • 434 citations

The oxygen free radical system: from equations through membrane-protein interactions to cardiovascular injury and protection

1992 • 400 citations

Membrane lipid oxidation

1990 • 389 citations

Spectrin-Based Membrane Skeleton: A Multipotential Adaptor Between Plasma Membrane and Cytoplasm

1991 • 373 citations

Free radicals and myocardial ischemia: Overview and outlook

1988 • 286 citations

Ankyrins. Adaptors between diverse plasma membrane proteins and the cytoplasm.

1992 • 276 citations

Costameres are sites of force transmission to the substratum in adult rat cardiomyocytes.

1992 • 275 citations

Oxygen radicals generated at reflow induce peroxidation of membrane lipids in reperfused hearts.

1991 • 274 citations

Cytoskeletal Role in the Contractile Dysfunction of Hypertrophied Myocardium

1993 • 273 citations

Aldehydes in biological systems

1977 • 259 citations

Vinculin is a component of an extensive network of myofibril-sarcolemma attachment regions in cardiac muscle fibers.

1983 • 245 citations

Modification of human low-density lipoprotein by the lipid peroxidation product 4-hydroxynonenal

1986 • 241 citations

Role of Tubulin -SH Groups in Polymerization to Microtubules

1974 • 237 citations

Brain ankyrin. A membrane-associated protein with binding sites for spectrin, tubulin, and the cytoplasmic domain of the erythrocyte anion channel.

1984 • 215 citations

Molecular heterogeneity of adherens junctions.

1985 • 200 citations

Modification of low density lipoprotein with 4-hydroxynonenal induces uptake by macrophages.

1989 • 186 citations

Expression of transformation-associated protease(s) that degrade fibronectin at cell contact sites.

1984 • 184 citations

Sulfhydryls and the in vitro polymerization of tubulin.

1976 • 181 citations

Cytoskeletal damage during myocardial ischemia: changes in vinculin immunofluorescence staining during total in vitro ischemia in canine heart.

1987 • 169 citations

Improved mountant for immunofluorescence preparations.

1974 • 161 citations

The cytoskeletal lattice of muscle cells

1992 • 156 citations

Taxol-induced flexibility of microtubules and its reversal by MAP-2 and Tau.

1993 • 149 citations

Ischaemia and the myocyte cytoskeleton: review and speculation

1993 • 143 citations

Potentiation of oxidative cell injury in hepatocytes which have accumulated Ca2+.

1984 • 133 citations

Free radicals alter ionic calcium levels and membrane phospholipids in cultured rat ventricular myocytes

1990 • 126 citations

The vinculin/sarcomeric-alpha-actinin/alpha-actin nexus in cultured cardiac myocytes

1992 • 126 citations

Selective cleavage of thioether linkage in proteins modified with 4-hydroxynonenal.

1992 • 125 citations

Release of arachidonate from membrane phospholipids in cultured neonatal rat myocardial cells during adenosine triphosphate depletion. Correlation with the progression of cell injury.

1985 • 122 citations

Cytoskeleton as a target in menadione-induced oxidative stress in cultured mammalian cells: Alterations underlying surface bleb formation

1991 • 113 citations

Pathophysiology of Reperfusion Injury

1992 • 97 citations

Desmin/vimentin intermediate filaments are dispensable for many aspects of myogenesis.

1991 • 96 citations

Diversity of vinculin/meta-vinculin in human tissues and cultivated cells. Expression of muscle specific variants of vinculin in human aorta smooth muscle cells.

1988 • 94 citations

Cytoskeletal lesions in anoxic myocardial injury. A conventional and high-voltage electron-microscopic and immunofluorescence study.

1987 • 94 citations

Alterations of ultrastructure and elemental composition in cultured neonatal rat cardiac myocytes after metabolic inhibition with iodoacetic acid.

1985 • 90 citations

Vinculin

1990 • 89 citations

Microtubules and desmin filaments during onset of heart hypertrophy in rat: a double immunoelectron microscope study.

1987 • 83 citations

Direct detection of endogenous hydroxyl radical production in cultured adult cardiomyocytes during anoxia and reoxygenation. Is the hydroxyl radical really the most damaging radical species?

1993 • 80 citations

An in vitro model of myocardial ischemia utilizing isolated adult rat myocytes

1990 • 79 citations

Distribution of vinculin in the Z‐disk of striated muscle: Analysis by laser scanning confocal microscopy

1990 • 75 citations

Reperfusion-induced injury: A possible role for oxidant stress and its manipulation

1991 • 73 citations

Myofibrillar and cytoskeletal assembly in neonatal rat cardiac myocytes cultured on laminin and collagen

1991 • 72 citations

Molecular analysis of intermediate filament cytoskeleton--a putative load-bearing structure

1984 • 72 citations

Oxidative Stress and Cytoskeletal Alterations^a

1992 • 69 citations

Microheterogeneity of avian and mammalian vinculin

1982 • 67 citations

The calcium uptake of the rat heart sarcoplasmic reticulum is altered by dietary lipid

1993 • 66 citations

Reperfusion after brief ischemia disrupts the microtubule network in canine hearts.

1993 • 65 citations

Association of spectrin with desmin intermediate filaments

1986 • 64 citations

Disruption of microtubules as an early sign of irreversible ischemic injury. Immunohistochemical study of in situ canine hearts.

1990 • 63 citations

Visualization of longitudinally-oriented intermediate filaments in frozen sections of chicken cardiac muscle by a new staining method.

1983 • 58 citations

Interaction between microtubule-associated protein tau and spectrin

1984 • 58 citations

Differential response of myofibrillar and cytoskeletal proteins in cells treated with phorbol myristate acetate.

1989 • 55 citations

Assembly and remodelling of myofibrils and intercalated discs in cultured neonatal rat heart cells

1986 • 51 citations

Free radical damage in neonatal rat cardiac myocyte cultures: Effects of α-tocopherol, trolox, and phytol

1990 • 47 citations

Human cardiac and skeletal muscle spectrins: Differential expression and localization

1992 • 46 citations

Cytoskeletal injury and subsarcolemmal bleb formation in dog heart during in vitro total ischemia.

1988 • 46 citations

Myofibril assembly is linked with vinculin, α‐actinin, and cell‐substrate contacts in embryonic cardiac myocytes in vitro

1989 • 41 citations

Different distributions of microtubules, desmin filaments and isomyosins during the onset of cardiac hypertrophy in the rat.

1984 • 40 citations

Incorporation of fluorescently labeled contractile proteins into freshly isolated living adult cardiac myocytes

1992 • 35 citations

Immunocytochemical studies of spectrin in hamster cardiac tissue

1989 • 30 citations

Intermediate filament and associated proteins in the human heart: An immunofluorescence study of normal and pathological hearts

1984 • 27 citations

Immunofluorescent localization of desmin and vimentin in developing cardiac muscle of Syrian hamster

1989 • 26 citations

4-Hydroxy-alkenals interaction with purified microtubular protein

1985 • 23 citations

Lipid abnormalities in myocardial cell injury

1991 • 22 citations

Morphologic and functional correlates of plasma membrane injury during oxidant exposure

1989 • 21 citations

Propanolol preserves ultrastructure in adult cardiocytes exposed to anoxia/reoxygenation: A morphometric analysis

1991 • 20 citations

Enzyme release from chick myocytes during hypoxia and reoxygenation: Dependence on pH

1989 • 20 citations

Bioassay screening for toxicants in oil samples from the toxic-oil syndrome outbreak in Spain

1985 • 19 citations

Altered distribution of desmin filaments in hypertrophic cardiomyopathy: an immunohistochemical study.

1992 • 14 citations

Pathobiology of Acute Myocardial Ischemia

1989 • 14 citations

Immunofluorescent studies on Z-line-associated protein in cultured cardiomyocytes from neonatal hamsters

1993 • 13 citations

Subcellular Distribution and Phosphorylation of Vinculin lsoforms in Human Blood Platelets

1991 • 11 citations

Composition and organization of sarcolemmal fatty acids in cultured neonatal rat cardiomyocytes

1990 • 11 citations

Effects of some aldehydes on brain microtubular protein

1991 • 11 citations

Myofibrillar organization and desmin in rat heart myocytes.

1985 • 9 citations

Oxygen Free Radicals in the Pathophysiology of Myocardial Ischemia/Reperfusion

1993 • 8 citations

Immunofluorescent and Immunogold Replica Studies of Desmin Distribution in Cultured Normal and Cardiomyopathic Hamster Heart Cells

1991 • 7 citations

Aldehyde‐induced modifications of the microtubular system in 3T3 fibroblasts

1992 • 4 citations