The effect of human tissue factor pathway inhibitor-2 on the growth and metastasis of fibrosarcoma tumors in athymic mice

Plasminogen Activators, Tissue Degradation, and Cancer

1985 • 2,584 citations

Biology and biochemistry of proteinases in tumor invasion

1993 • 1,264 citations

Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis

2001 • 957 citations

The Membrane-Anchored MMP Inhibitor RECK Is a Key Regulator of Extracellular Matrix Integrity and Angiogenesis

2001 • 699 citations

Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells

1998 • 551 citations

Clinical, Cellular, and Molecular Aspects of Cancer Invasion

2003 • 509 citations

Regulation of matrix metalloproteinase-9 and inhibition of tumor invasion by the membrane-anchored glycoprotein RECK

1998 • 496 citations

Thrombospondin-1 suppresses spontaneous tumor growth and inhibits activation of matrix metalloproteinase-9 and mobilization of vascular endothelial growth factor

2001 • 463 citations

Prevention of metastasis by inhibition of the urokinase receptor.

1993 • 387 citations

Urokinase receptor antagonists inhibit angiogenesis and primary tumor growth in syngeneic mice.

1996 • 250 citations

Complete inhibition of rhabdomyosarcoma xenograft growth and neovascularization requires blockade of both tumor and host vascular endothelial growth factor.

2000 • 244 citations

Tissue factor pathway inhibitor-2 is a novel inhibitor of matrix metalloproteinases with implications for atherosclerosis

2001 • 219 citations

Aven, a Novel Inhibitor of Caspase Activation, Binds Bcl-xL and Apaf-1

2000 • 205 citations

Molecular cloning, expression, and partial characterization of a second human tissue-factor-pathway inhibitor.

1994 • 203 citations

The plasminogen-plasmin system in malignancy

1992 • 190 citations

Deletion of neuropeptide Y (NPY) 2 receptor in mice results in blockage of NPY-induced angiogenesis and delayed wound healing

2003 • 184 citations

MIM, a Potential Metastasis Suppressor Gene in Bladder Cancer

2002 • 172 citations

Expression of plasminogen activator inhibitor type 1 by human prostate carcinoma cells inhibits primary tumor growth, tumor-associated angiogenesis, and metastasis to lung and liver in an athymic mouse model.

1995 • 160 citations

Metastatic behavior of human melanoma cell lines in nude mice correlates with urokinase-type plasminogen activator, its type-1 inhibitor, and urokinase-mediated matrix degradation.

1991 • 156 citations

Binding of urokinase to its receptor promotes migration and invasion of human melanoma cells in vitro.

1994 • 155 citations

Vegf, vegf-B, vegf-C and their receptors KDR, FLT-1 and FLT-4 during the neoplastic progression of human colonic mucosa

2000 • 150 citations

Inhibitory Properties of a Novel Human Kunitz-Type Protease Inhibitor Homologous to Tissue Factor Pathway Inhibitor

1996 • 147 citations

RECK: a novel suppressor of malignancy linking oncogenic signaling to extracellular matrix remodeling.

2003 • 136 citations

Plasmin-induced Migration of Endothelial Cells

2002 • 130 citations

Molecular Profiling of Angiogenesis Markers

2002 • 129 citations

Upregulation of MMPs by soluble E‐cadherin in human lung tumor cells

2003 • 125 citations

Receptor Protein-tyrosine Phosphatase RPTPμ Binds to and Dephosphorylates the Catenin p120

2000 • 122 citations

cDNA Cloning and mRNA Expression of a Serine Proteinase Inhibitor Secreted by Cancer Cells: Identification as Placental Protein 5 and Tissue Factor Pathway Inhibitor-2

1994 • 111 citations

γ-Catenin expression is reduced or absent in a subset of human lung cancers and re-expression inhibits transformed cell growth

2002 • 107 citations

FRL, a Novel Formin-Related Protein, Binds to Rac and Regulates Cell Motility and Survival of Macrophages

2000 • 104 citations

Quantification and Characterization of Human Endothelial Cell–Derived Tissue Factor Pathway Inhibitor-2

1998 • 98 citations

Regulation of ProMMP-1 and ProMMP-3 Activation by Tissue Factor Pathway Inhibitor-2/Matrix-Associated Serine Protease Inhibitor

1999 • 96 citations

Tumor Necrosis Factor Alpha-Induced Interleukin-8 Production via NF-κB and Phosphatidylinositol 3-Kinase/Akt Pathways Inhibits Cell Apoptosis in Human Hepatocytes

2002 • 95 citations

Extracellular Matrix-Associated Serine Protease Inhibitors (Mr33,000, 31,000, and 27,000) Are Single-Gene Products with Differential Glycosylation: cDNA Cloning of the 33-kDa Inhibitor Reveals Its Identity to Tissue Factor Pathway Inhibitor-2

1996 • 94 citations

[15] High efficiency fusion procedure for producing monoclonal antibodies against weak immunogens

1986 • 84 citations

Plasmin Produces an E-Cadherin Fragment That Stimulates Cancer Cell Invasion

2002 • 81 citations

A novel function of tissue factor pathway inhibitor-2 (TFPI-2) in human glioma invasion

2001 • 79 citations

HT-1080 fibrosarcoma cell matrix degradation and invasion are inhibited by the matrix-associated serine protease inhibitor TFPI-2/33 kDa MSPI

1998 • 77 citations

Tissue factor pathway inhibitor‐2 suppresses the production of active matrix metalloproteinase‐2 and is down‐regulated in cells harboring activated ras oncogenes

2000 • 68 citations

Anti-angiogenic action of hyperthermia by suppressing gene expression and production of tumour-derived vascular endothelial growth factor in vivo and in vitro

2002 • 64 citations

Novel Extracellular Matrix-Associated Serine Proteinase Inhibitors from Human Skin Fibroblasts

1995 • 64 citations

Expression and Localization of Tissue Factor Pathway Inhibitor-2 in Normal and Atherosclerotic Human Vessels

2002 • 55 citations

Binding and Activation of Plasminogen at the Surface of Human Keratinocytes

1993 • 53 citations

Urothelial function reconsidered: A role in urinary protein secretion

2001 • 53 citations

Expression of Serine Proteinase Inhibitor PP5/TFPI-2/MSPI Decreases the Invasive Potential of Human Choriocarcinoma Cells in Vitro and in Vivo

2001 • 44 citations

Plasminogen activation by t-PA on the surface of human melanoma cells in the presence of alpha 2-macroglobulin secretion.

1990 • 44 citations

Partial Characterization of Matrix-Associated Serine Protease Inhibitors from Human Skin Cells

1995 • 33 citations

Plasmin in pericellular proteolysis and cellular invasion.

1994 • 32 citations

Inhibitory Properties of Human Recombinant Arg24→Gln Type-2 Tissue Factor Pathway Inhibitor (R24Q TFPI-2)

1999 • 21 citations

CD4 dependence of gp120IIIB-CXCR4 interaction is cell-type specific

2003 • 21 citations

Comparison of techniques for the successful detection of BRCA1 mutations in fixed paraffin-embedded tissue.

2002 • 16 citations