γ-Secretase Cleavage and Binding to FE65 Regulate the Nuclear Translocation of the Intracellular C-Terminal Domain (ICD) of the APP Family of Proteins

Translating cell biology into therapeutic advances in Alzheimer's disease

1999 • 1,592 citations

At least six nucleotides preceding the AUG initiator codon enhance translation in mammalian cells

1987 • 1,189 citations

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

1999 • 1,072 citations

Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives

1997 • 991 citations

A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

2002 • 676 citations

Mice with Combined Gene Knock-Outs Reveal Essential and Partially Redundant Functions of Amyloid Precursor Protein Family Members

2000 • 485 citations

The Intracellular Domain of the β-Amyloid Precursor Protein Is Stabilized by Fe65 and Translocates to the Nucleus in a Notch-like Manner

2001 • 439 citations

Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid β protein precursor

1993 • 388 citations

Effects of PS1 Deficiency on Membrane Protein Trafficking in Neurons

1998 • 356 citations

Expression of a ubiquitous, cross-reactive homologue of the mouse beta-amyloid precursor protein (APP).

1994 • 349 citations

New Perspectives on Alzheimer's Disease

1986 • 349 citations

Age-related cognitive deficits, impaired long-term potentiation and reduction in synaptic marker density in mice lacking the β-amyloid precursor protein

1999 • 346 citations

Presenilin-1 and -2 Are Molecular Targets for γ-Secretase Inhibitors

2000 • 300 citations

The Transmembrane Aspartates in Presenilin 1 and 2 Are Obligatory for γ-Secretase Activity and Amyloid β-Protein Generation

2000 • 253 citations

Downregulation of amyloid precursor protein inhibits neurite outgrowth in vitro.

1995 • 248 citations

Insulin-degrading Enzyme Rapidly Removes the β-Amyloid Precursor Protein Intracellular Domain (AICD)

2002 • 207 citations

The intracellular cytoplasmic domain of the Alzheimer's disease amyloid precursor protein interacts with phosphotyrosine‐binding domain proteins in the yeast two‐hybrid system

1996 • 153 citations

The β-Amyloid Precursor Protein Functions as a Cytosolic Anchoring Site That Prevents Fe65 Nuclear Translocation

2001 • 129 citations

Fe65L2: a new member of the Fe65 protein family interacting with the intracellular domain of the Alzheimer's β-amyloid precursor protein

1998 • 97 citations

Fe65, a Ligand of the Alzheimer's β-Amyloid Precursor Protein, Blocks Cell Cycle Progression by Down-regulating Thymidylate Synthase Expression

2002 • 82 citations

Amyloid precursor-like protein 2 (APLP2) is modified by the addition of chondroitin sulfate glycosaminoglycan at a single site.

1994 • 66 citations

Human Amyloid Precursor‐Like Protein 1

1997 • 65 citations

Molecular cloning of human Fe65L2 and its interaction with the Alzheimer's β-amyloid precursor protein

1999 • 43 citations