Soluble TNF and membrane TNF expressed on CD4+ T lymphocytes differ In their ability to activate macrophage antileishmanial defense

The Cell Biology of Macrophage Activation

1984 • 1,623 citations

A novel form of TNF/cachectin is a cell surface cytotoxic transmembrane protein: Ramifications for the complex physiology of TNF

1988 • 1,105 citations

T-Lymphocyte Recognition of Antigen in Association with Gene Products of the Major Histocompatibility Complex

1985 • 942 citations

TUMOR NECROSIS, CACHEXIA, SHOCK, AND INFLAMMATION: A COMMON MEDIATOR

1988 • 814 citations

Comparison of in vitro cell cytotoxic assays for tumor necrosis factor

1984 • 752 citations

Differentiation of murine macrophages to express nonspecific cytotoxicity for tumor cells results in L-arginine-dependent inhibition of mitochondrial iron-sulfur enzymes in the macrophage effector cells.

1988 • 592 citations

Tumor necrosis factor-alpha synergizes with IFN-gamma in mediating killing of Leishmania major through the induction of nitric oxide.

1990 • 531 citations

Leishmania major amastigotes initiate the L-arginine-dependent killing mechanism in IFN-gamma-stimulated macrophages by induction of tumor necrosis factor-alpha.

1990 • 453 citations

Generation and characterization of hamster monoclonal antibodies that neutralize murine tumor necrosis factors.

1989 • 385 citations

Receptor-directed focusing of lymphokine release by helper T cells

1988 • 284 citations

Tumour necrosis factor (TNF alpha) in leishmaniasis. I. TNF alpha mediates host protection against cutaneous leishmaniasis.

1990 • 168 citations

Activity of recombinant tumor necrosis factor on Toxoplasma gondii and Trypanosoma cruzi.

1986 • 143 citations

A novel addition to the T cell repertory. Cell surface expression of tumor necrosis factor/cachectin by activated normal human T cells.

1990 • 133 citations

Evidence for the existence of two forms of membrane tumor necrosis factor: an integral protein and a molecule attached to its receptor.

1989 • 119 citations

Cutaneous Leishmaniasis—a Case with Persistent Organisms after Treatment in Presence of Normal Immune Response

1979 • 68 citations

Macrophage activation to kill Leishmania tropica: defective intracellular killing of amastigotes by macrophages elicited with sterile inflammatory agents.

1984 • 67 citations

Identification and characterization of a membrane-bound cytotoxin of murine cytolytic lymphocytes that is related to tumor necrosis factor/cachectin.

1989 • 65 citations

Antileishmanial defense in macrophages triggered by tumor necrosis factor expressed on CD4+ T lymphocyte plasma membrane.

1991 • 60 citations

Cell contact-mediated macrophage activation for antileishmanial defense. I. Lymphocyte effector mechanism that is contact dependent and noncytotoxic.

1984 • 32 citations

Impaired macrophage leishmanicidal activity at cutaneous temperature

1985 • 32 citations

Th2 lymphocyte clone can activate macrophage antileishmanial defense by a lymphokine-independent mechanism in vitro and can augment parasite attrition in vivo

1991 • 14 citations

T-cell hybridomas reveal two distinct mechanisms of antileishmanial defense

1990 • 13 citations

Susceptibility of Lymphokine-Resistant Leishmania to Cell Contact-Mediated Macrophage Activation

1988 • 8 citations