Interleukin-3 induces antimicrobial activity against Leishmania amazonensis and Trypanosoma cruzi and tumoricidal activity in human peripheral blood-derived macrophages

The Human Hematopoietic Colony-Stimulating Factors

1987 • 1,728 citations

A Short Polypeptide Marker Sequence Useful for Recombinant Protein Identification and Purification

1988 • 934 citations

Human IL-3 (multi-CSF): Identification by expression cloning of a novel hematopoietic growth factor related to murine IL-3

1986 • 823 citations

Tumour necrosis factor as immunomodulator and mediator of monocyte cytotoxicity induced by itself, γ-interferon and interleukin-1

1986 • 781 citations

The extinction coefficient of cytochrome c

1962 • 693 citations

Activated macrophages destroy intracellular Leishmania major amastigotes by an L-arginine-dependent killing mechanism.

1990 • 690 citations

Tumor necrosis factor-alpha synergizes with IFN-gamma in mediating killing of Leishmania major through the induction of nitric oxide.

1990 • 531 citations

Hematopoietic Growth Factors

1989 • 465 citations

Interferon-Gamma, the Activated Macrophage, and Host Defense Against Microbial Challenge

1988 • 428 citations

Human CSF-1: Molecular Cloning and Expression of 4-kb cDNA Encoding the Human Urinary Protein

1987 • 381 citations

Human Recombinant Granulocyte-Macrophage Colony-Stimulating Factor: A Multilineage Hematopoietin

1985 • 374 citations

Cell-associated tumor necrosis factor (TNF) as a killing mechanism of activated cytotoxic macrophages.

1987 • 361 citations

Tumor necrosis factor: a potent effector molecule for tumor cell killing by activated macrophages.

1986 • 360 citations

Activation of mouse peritoneal macrophages in vitro and in vivo by interferon-gamma.

1985 • 356 citations

Human IL-3 and GM-CSF Act Synergistically in Stimulating Hematopoiesis in Primates

1988 • 333 citations

Cloning, sequence, and expression of a human granulocyte/macrophage colony-stimulating factor.

1985 • 314 citations

Colony-stimulating factor-induced monocyte survival and differentiation into macrophages in serum-free cultures.

1987 • 270 citations

In vivo administration of recombinant IFN-gamma induces macrophage activation, and prevents acute disease, immune suppression, and death in experimental Trypanosoma cruzi infections.

1988 • 256 citations

Tumor necrosis factor plays a protective role in experimental murine cutaneous leishmaniasis.

1989 • 256 citations

Macrophage-activating factor produced by a T cell hybridoma: physiochemical and biosynthetic resemblance to gamma-interferon.

1983 • 236 citations

Human granulocyte-monocyte colony-stimulating factor and interleukin 3 stimulate monocyte cytotoxicity through a tumor necrosis factor- dependent mechanism

1988 • 221 citations

Recombinant granulocyte/macrophage colony-stimulating factor activates macrophages to inhibit Trypanosoma cruzi and release hydrogen peroxide. Comparison with interferon gamma.

1987 • 215 citations

Recombinant human granulocyte/macrophage colony-stimulating factor activates intracellular killing of Leishmania donovani by human monocyte-derived macrophages.

1987 • 194 citations

Tumor necrosis factor is an important mediator of tumor cell killing by human monocytes.

1987 • 192 citations

Recognition and destruction of neoplastic cells by activated macrophages: discrimination of altered self

1988 • 186 citations

Tumour necrosis factor (TNF alpha) in leishmaniasis. I. TNF alpha mediates host protection against cutaneous leishmaniasis.

1990 • 168 citations

Heterogeneity in Human Interleukin-3 Receptors

1989 • 153 citations

Activity of recombinant tumor necrosis factor on Toxoplasma gondii and Trypanosoma cruzi.

1986 • 143 citations

Synergistic activation of human monocytes by granulocyte-macrophage colony-stimulating factor and IFN-gamma. Increased TNF-alpha but not IL-1 activity.

1988 • 139 citations

Enhancement of human monocyte function against Candida albicans by the colony-stimulating factors (CSF): IL-3, granulocyte-macrophage-CSF, and macrophage-CSF.

1989 • 139 citations

Recombinant human interleukin-3 and granulocyte-macrophage colony- stimulating factor show common biological effects and binding characteristics on human monocytes

1989 • 133 citations

Recombinant human interleukin-3 stimulation of hematopoiesis in humans: loss of responsiveness with differentiation in the neutrophilic myeloid series

1988 • 100 citations

Stimulation of macrophage tumoricidal activity by the growth and differentiation factor CSF-1

1987 • 92 citations

Potent activation of mouse macrophages by recombinant interferon-gamma.

1984 • 89 citations

Enhancement of human monocyte tumoricidal activity by recombinant M-CSF.

1988 • 75 citations

Interleukin-4 Inhibits Human Macrophage Activation by Tumor Necrosis Factor, Granulocyte-Monocyte Colony-Stimulating Factor, and Interleukin-3 for Antileishmanial Activity and Oxidative Burst Capacity

1992 • 66 citations

Aggravation of experimental cutaneous leishmaniasis in mice by administration of interleukin 3

1988 • 62 citations

Granulocyte-Macrophage and Macrophage Colony-Stimulating Factors Activate Intramacrophage Killing of Leishmania mexicana amazonensis

1990 • 59 citations

Inhibition of neutrophil oxidative metabolism by lysosomotropic weak bases

1986 • 57 citations

Effect of recombinant granulocyte/macrophage colony-stimulating factor on human monocyte activity in vitro and following intravenous administration.

1988 • 44 citations

Human monocyte activation for cytotoxicity against intracellular Leishmania donovani amastigotes: Induction of microbicidal activity by Interferon-γ

1985 • 44 citations

A study of the sensitivity ofLeishmania donovanipromastigotes and amastigotes to hydrogen peroxide. I. Differences in sensitivity correlate with parasite-mediated removal of hydrogen peroxide

1985 • 41 citations

Involvement of tumour necrosis factor in monocyte-mediated rapid killing of actinomycin D-pretreated WEHI 164 sarcoma cells.

1986 • 37 citations

Diminished Activity of Protein Kinase C in Tetanus Toxin-Treated Macrophages and in the Spinal Cord of Mice Manifesting Generalized Tetanus Intoxication

1988 • 21 citations

Coordinate Actions of Growth Factors in Monocytes/Macrophages

1990 • 16 citations

Antimicrobial Functions of Macrophages

1989 • 10 citations