Calcium/calmodulin-dependent protein kinase II activity in focal ischemia with reperfusion in rats.

Glutamate and the pathophysiology of hypoxic–ischemic brain damage

1986 • 2,428 citations

Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage

1988 • 1,745 citations

Calcium Dependence of Toxic Cell Death: A Final Common Pathway

1979 • 1,478 citations

Impaired Spatial Learning in α-Calcium-Calmodulin Kinase II Mutant Mice

1992 • 1,336 citations

Inhibition of Postsynaptic PKC or CaMKII Blocks Induction But Not Expression of LTP

1989 • 1,335 citations

Calcium Fluxes, Calcium Antagonists, and Calcium-Related Pathology in Brain Ischemia, Hypoglycemia, and Spreading Depression: A Unifying Hypothesis

1989 • 1,237 citations

Cerebral hypoxia: some new approaches and unanswered questions

1990 • 674 citations

The neurotoxicity of excitatory amino acids is produced by passive chloride influx

1985 • 634 citations

Calcium and Ischemic Injury

1986 • 529 citations

Focal Brain Ischemia in the Rat: Methods for Reproducible Neocortical Infarction Using Tandem Occlusion of the Distal Middle Cerebral and Ipsilateral Common Carotid Arteries

1988 • 488 citations

Excitatory amino acids activate calpain I and induce structural protein breakdown in vivo

1988 • 437 citations

Historical Overview

1988 • 428 citations

Brain Cortical Fatty Acids and Phospholipids During and Following Complete and Severe Incomplete Ischemia

1982 • 387 citations

Mechanism of Kainate Toxicity to Cerebellar Neurons In Vitro Is Analogous to Reperfusion Tissue Injury

1987 • 334 citations

Temporal thresholds for neocortical infarction in rats subjected to reversible focal cerebral ischemia.

1991 • 325 citations

Calcium/calmodulin-dependent protein kinase II increases glutamate and noradrenaline release from synaptosomes

1990 • 284 citations

Transient Formation of Superoxide Radicals in Polyunsaturated Fatty Acid‐Induced Brain Swelling

1980 • 267 citations

Inciting Excitotoxic Cytocide Among Central Neurons

1986 • 231 citations

The excitotoxin hypothesis in relation to cerebral ischemia.

1991 • 204 citations

Multifunctional Ca2+/calmodulin-dependent protein kinase: domain structure and regulation

1989 • 136 citations

Ischemia‐Induced Translocation of Ca²⁺/Calmodulin‐Dependent Protein Kinase II: Potential Role in Neuronal Damage

1992 • 134 citations

Effects of synapsin I and calcium/calmodulin-dependent protein kinase II on spontaneous neurotransmitter release in the squid giant synapse.

1990 • 122 citations

Protein kinases and phosphorylation in neurologic disorders and cell death.

1991 • 108 citations

Ca2+/calmodulin kinase is activated by the phosphatidylinositol signaling pathway and becomes Ca2(+)-independent in PC12 cells.

1990 • 98 citations

Regulation of CI− channels by multifunctional CaM kinase

1991 • 68 citations

Structure and Regulation of Type II Calcium/Calmodulin-dependent Protein Kinase in Central Nervous System Neurons

1990 • 65 citations

Regional and Temporal Alterations in Ca²⁺/Calmodulin‐Dependent Protein Kinase II and Calcineurin in the Hippocampus of Rat Brain After Transient Forebrain Ischemia

1992 • 65 citations

Cerebral ischemia decreases endogenous calcium-dependent protein phosphorylation in gerbil brain

1988 • 64 citations

Immunohistochemical Determination of Calcium—Calmodulin Binding Predicts Neuronal Damage after Global Ischemia

1989 • 56 citations

Global Forebrain Ischemia Induces a Posttranslational Modification of Multifunctional Calcium‐ and Calmodulin‐Dependent Kinase II

1992 • 54 citations

Possible mechanisms limiting N-methyl-D-aspartate receptor overactivation and the therapeutic efficacy of N-methyl-D-aspartate antagonists.

1990 • 50 citations

Threshold of calcium disturbances after focal cerebral ischemia in rats. Implications of the window of therapeutic opportunity.

1993 • 39 citations

Global Forebrain Ischemia Results in Decreased Immunoreactivity of Calcium/Calmodulin-Dependent Protein Kinase II

1992 • 37 citations

Protein phosphorylation during ischemia.

1990 • 31 citations

Serine/threonine kinases in the nervous system

1991 • 30 citations

Neuronal Protection and Preservation of Calcium/Calmodulin-Dependent Protein Kinase II and Protein Kinase C Activity by Dextrorphan Treatment in Global Ischemia

1993 • 30 citations

Functional analysis of Ca2+/calmodulin-dependent protein kinase II expressed in bacteria

1989 • 27 citations