Reversal of increased anxiety during benzodiazepine withdrawal: Evidence for an anxiogenic endogenous ligand for the benzodiazepine receptor

Validation of open : closed arm entries in an elevated plus-maze as a measure of anxiety in the rat

1985 • 5,596 citations

Anxiolytic and anxiogenic drug effects on exploratory activity in an elevated plus-maze: A novel test of anxiety in the rat

1986 • 1,509 citations

Withdrawal reactions from chlordiazepoxide (?Librium?)

1961 • 340 citations

Intrinsic actions of the benzodiazepine receptor antagonist Ro 15-1788

1986 • 314 citations

Chronic benzodiazepine treatment decreases postsynaptic GABA sensitivity

1984 • 279 citations

Tolerance to the behavioral actions of benzodiazepines

1985 • 200 citations

Acute and chronic effects of the benzodiazepine receptor ligand FG 7142: proconvulsant properties and kindling

1984 • 136 citations

Metrazol tolerance in a “normal” volunteer population

1958 • 91 citations

METRAZOL TOLERANCE IN A “NORMAL” VOLUNTEER POPULATION

1970 • 80 citations

THE METABOLIC FATE OF C14-LABELED CHLORDIAZEPOXIDE IN MAN, IN THE DOG, AND IN THE RAT.

1965 • 77 citations

Endogenous ligands for benzodiazepine recognition sites

1985 • 72 citations

Anxiogenic effects in benzodiazepine withdrawal are linked to the development of tolerance

1987 • 66 citations

Spontaneous and Ro 15-1788-induced reversal of subsensitivity to GABA following chronic benzodiapines

1985 • 61 citations

Changes in noradrenaline plasma levels and behavioural responses induced by benzodiazepine agonists with the benzodiazepine antagonist Ro 15-1788

1986 • 55 citations

Protracted treatment with diazepam increases the turnover of putative endogenous ligands for the benzodiazepine/beta-carboline recognition site.

1987 • 53 citations

The pentylenetetrazol model of anxiety detects withdrawal from diazepam in rats

1983 • 48 citations

Kindling and withdrawal changes at the benzodiazepine receptor

1987 • 41 citations

Dependence liability of the benzodiazepines

1984 • 39 citations

Evidence for the role of brain norepinephrine and dopamine in “rebound” phenomenon seen during withdrawal after repeated exposure to benzodiazepines

1977 • 37 citations

Reversal by alpha-2 agonists of diazepam withdrawal hyperactivity in rats

1986 • 35 citations

Mice and rats are sensitized to the proconvulsant action of a benzodiazepine-receptor inverse agonist (FG 7142) following a single dose of lorazepam

1986 • 33 citations

Lack of tolerance development to benzodiazepines in antagonism of the pentylenetetrazol discriminative stimulus

1979 • 23 citations

Does the behavioural activation detected after a single dose of a benzodiazepine reflect a withdrawal response?

1988 • 8 citations