The NMDA receptor antagonist MK-801 elicits conditioned place preference in rats

The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.

1986 • 1,814 citations

Systemic administration of MK-801 protects against ischemia-induced hippocampal neurodegeneration in the gerbil

1987 • 647 citations

Anticonvulsant activity of (+)‐5‐methyl‐10, 11‐dihydro‐5H‐dibenzo[a, d]cyclohepten‐5, 10‐imine (MK‐801), a substance with potent anticonvulsant, central sympathomimetic, and apparent anxiolytic properties

1982 • 496 citations

Role for Excitatory Amino Acids in Methamphetamine-Induced Nigrostriatal Dopaminergic Toxicity

1989 • 495 citations

Central sympathomimetic activity of (+)‐5‐methyl‐10,11‐dihydro‐5H‐dibenzo [a, d]cyclohepten‐5,10‐imine (MK‐801), a substance with potent anticonvulsant, central sympathomimetic, and apparent anxiolytic properties

1982 • 229 citations

SCH 23390 blocks drug-conditioned place-preference and place-aversion: anhedonia (lack of reward) or apathy (lack of motivation) after dopamine-receptor blockade?

1989 • 211 citations

Modulation of Glutamate Receptors: Molecular Mechanisms and Functional Implications

1989 • 198 citations

The use of place conditioning in studying the neuropharmacology of drug reinforcement

1989 • 193 citations

Non-competitive antagonists are potent activators of ventral tegmental A10 dopamine neurons

1990 • 157 citations

The receptor antagonist MK-801 induces increases in dopamine and serotonin metabolism in several brain regions of rats

1991 • 152 citations

Interactions of Phencyclidine Receptor Agonist MK‐801 with Dopaminergic System: Regional Studies in the Rat

1990 • 112 citations

The self-administration of MK-801 can depend upon drug-reinforcement history, and its discriminative stimulus properties are phencyclidine-like in rhesus monkeys.

1990 • 88 citations

Place conditioning with morphine and phencyclidine: Dose dependent effects

1985 • 84 citations

The effect of MK-801 and other antagonists of NMDA-type glutamate receptors on brain-stimulation reward

1989 • 72 citations

Phencyclidine use among youth: history, epidemiology, and acute and chronic intoxication.

1978 • 62 citations

Possible abuse potential of the NMDA antagonist MK-801

1989 • 59 citations

Animal models of intravenous phencyclinoid self-administration

1987 • 29 citations