Protein folding funnels: the nature of the transition state ensemble

Funnels, pathways, and the energy landscape of protein folding: A synthesis

1995 • 2,607 citations

Sickle Cell Anemia, a Molecular Disease

1949 • 2,216 citations

Spin glasses and the statistical mechanics of protein folding.

1987 • 1,608 citations

Principles of protein folding — A perspective from simple exact models

1995 • 1,532 citations

Dynamics of Proteins and Nucleic Acids

1988 • 1,274 citations

Navigating the Folding Routes

1995 • 1,193 citations

Computer Modeling of Chemical Reactions in Enzymes and Solutions

1991 • 1,129 citations

Protein folding funnels: a kinetic approach to the sequence-structure relationship.

1992 • 923 citations

Folding of chymotrypsin inhibitor 2. 1. Evidence for a two-state transition

1991 • 882 citations

Intermediates and barrier crossing in a random energy model (with applications to protein folding)

1989 • 748 citations

The Structure of the Transition State for Folding of Chymotrypsin Inhibitor 2 Analysed by Protein Engineering Methods: Evidence for a Nucleation-condensation Mechanism for Protein Folding

1995 • 745 citations

The folding of hen lysozyme involves partially structured intermediates and multiple pathways

1992 • 719 citations

Kinetics of Protein Folding

1994 • 572 citations

Toward an outline of the topography of a realistic protein-folding funnel.

1995 • 510 citations

Theory of Elastic Mechanisms in Fibrous Proteins

1956 • 497 citations

The barriers in protein folding

1994 • 436 citations

Diffusive dynamics of the reaction coordinate for protein folding funnels

1996 • 436 citations

First-Principles Calculation of the Folding Free Energy of a Three-Helix Bundle Protein

1995 • 392 citations

The nature of folded states of globular proteins

1992 • 378 citations

Kinetics of protein folding: Nucleation mechanism, time scales, and pathways

1995 • 348 citations

Evidence for a three-state model of protein folding from kinetic analysis of ubiquitin variants with altered core residues

1996 • 347 citations

Conserved residues and the mechanism of protein folding

1996 • 347 citations

Optimal protein-folding codes from spin-glass theory.

1992 • 341 citations

Protein Folding Triggered by Electron Transfer

1996 • 307 citations

Fast events in protein folding initiated by nanosecond laser photolysis.

1993 • 306 citations

Kinetic Mechanism of Cytochrome c Folding: Involvement of the Heme and Its Ligands

1994 • 274 citations

Folding kinetics of proteinlike heteropolymers

1994 • 263 citations

On-pathway versus off-pathway folding intermediates

1996 • 259 citations

Submillisecond folding of monomeric lambda repressor.

1995 • 218 citations

Chemical Dynamics in Solution

1990 • 209 citations

Classical and quantum pictures of reaction dynamics in condensed matter: resonances, dephasing, and all that

1988 • 209 citations

Structure of the transition state for folding of the 129 aa protein CheY resembles that of a smaller protein, CI-2

1996 • 174 citations

A simple statistical field theory of heteropolymer collapse with application to protein folding

1990 • 160 citations

Kinetic and thermodynamic analysis of proteinlike heteropolymers: Monte Carlo histogram technique

1995 • 155 citations

Exploring the energy surface of protein folding by structure-reactivity relationships and engineered proteins: Observation of Hammond behavior for the gross structure of the transition state and anti-Hammond behavior for structural elements for unfolding/folding of barnase

1995 • 129 citations

The Biophysics of Sickle Cell Hydroxyurea Therapy

1995 • 96 citations

Correlated energy landscape model for finite, random heteropolymers

1996 • 95 citations

Modeling the role of disulfide bonds in protein folding: Entropic barriers and pathways

1995 • 83 citations

Energy landscapes, glass transitions, and chemical reaction dynamics in biomolecular or solvent environment

1993 • 63 citations

Local Conformational Signals and the Statistical Thermodynamics of Collapsed Helical Proteins

1996 • 62 citations

Helix-Coil, Liquid Crystal, and Spin Glass Transitions of a Collapsed Heteropolymer

1995 • 59 citations

Protein Folds: A Distance-Based Approach

1995 • 57 citations

Kinetics of proteinlike models: The energy landscape factors that determine folding

1995 • 54 citations

Molecular dynamics of associative memory hamiltonians for protein tertiary structure recognition

1990 • 23 citations

Dynamics of proteins and nucleic acids

1989 • 21 citations

Structure and Dynamics of Solvent Landscapes in Charge-Transfer Reactions

1996 • 19 citations