Early-onset myasthenia gravis: A recurring T-cell epitope in the adult-specific acetylcholine receptor ? subunit presented by the susceptibility allele HLA-DR52a

[6] Use of T7 RNA polymerase to direct expression of cloned genes

1990 • 6,681 citations

Myasthenia Gravis

1997 • 2,469 citations

T cell tolerance by clonal elimination in the thymus

1987 • 2,248 citations

Myasthenia Gravis

1994 • 1,090 citations

Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention

1988 • 940 citations

Progesterone favors the development of human T helper cells producing Th2-type cytokines and promotes both IL-4 production and membrane CD30 expression in established Th1 cell clones.

1995 • 731 citations

Determinant spreading and the dynamics of the autoimmune T-cell repertoire

1993 • 467 citations

CLINICAL, PATHOLOGICAL, HLA ANTIGEN AND IMMUNOLOGICAL EVIDENCE FOR DISEASE HETEROGENEITY IN MYASTHENIA GRAVIS

1980 • 465 citations

Myasthenia Gravis

1988 • 341 citations

Suppressive vaccination with DNA encoding a variable region gene of the T–cell receptor prevents autoimmune encephalomyelitis and activates Th2 immunity

1996 • 244 citations

Acetylcholine receptors in human thymic myoid cells in situ: An immunohistological study

1987 • 226 citations

T-cell tolerance toward a transgenic beta-cell antigen and transcription of endogenous pancreatic genes in thymus.

1994 • 223 citations

Localization of the main immunogenic region of human muscle acetylcholine receptor to residues 67-76 of the alpha subunit.

1988 • 215 citations

Interferon γ (IFN-γ) Is Necessary for the Genesis of Acetylcholine Receptor–induced Clinical Experimental Autoimmune Myasthenia gravis in Mice

1997 • 183 citations

Acetylcholine receptor antibody synthesis by thymic lymphocytes

1981 • 182 citations

Acetylcholine receptor antibody characteristics in myasthenia gravis. I. Patients with generalized myasthenia or disease restricted to ocular muscles.

1982 • 161 citations

An approach to the localization of the susceptibility genes for generalized myasthenia gravis by mapping recombinant ancestral haplotypes

1992 • 133 citations

The Physiological Role of Regulatory T Cells in the Prevention of Autoimmunity: the Function of the Thymus in the Generation of the Regulatory T Cell Subset

1996 • 121 citations

The human muscle nicotinic acetylcholine receptor alpha-subunit exist as two isoforms: a novel exon.

1990 • 112 citations

Myasthenia gravis: recognition of a human autoantigen at the molecular level

1993 • 104 citations

IL-12 is involved in the induction of experimental autoimmune myasthenia gravis, an antibody- mediated disease

1998 • 103 citations

Determinant spreading and immune responses to acetylcholine receptors in myasthenia gravis

1998 • 102 citations

Myasthenia gravis

1993 • 100 citations

Critical role for the Val/Gly86 HLA-DR beta dimorphism in autoantigen presentation to human T cells.

1991 • 97 citations

Acetylcholine receptor expression in human extraocular muscles and their susceptibility to myasthenia gravis

1997 • 87 citations

Characterization of the human T cell receptor α‐chain repertoire and demonstration of a genetic influence on Vα usage

1993 • 84 citations

Inherited polymorphism of the human T-cell antigen receptor detected by a monoclonal antibody.

1986 • 81 citations

Specific tolerance to an acetylcholine receptor epitope induced in vitro in myasthenia gravis CD4+ lymphocytes by soluble major histocompatibility complex class II-peptide complexes.

1994 • 77 citations

Primary structure of the human muscle acetylcholine receptor

1993 • 73 citations

Identification of genomic typing of non-DR3 HLA class II genes associated with myasthenia gravis

1993 • 71 citations

An integrin polymorphism that defines reactivity with alloantibodies generates an anchor for MHC class II peptide binding: a model for unidirectional alloimmune responses.

1997 • 67 citations

HLA antigens and acetylcholine receptor antibodies in penicillamine induced myasthenia gravis.

1983 • 66 citations

Peptide-selected T cell lines from myasthenia gravis patients and controls recognize epitopes that are not processed from whole acetylcholine receptor.

1995 • 61 citations

Expression of the Gastric H/K-ATPase α-Subunit in the Thymus may Explain the Dominant Role of the β-Subunit in the Pathogenesis of Autoimmune Gastritis

1997 • 57 citations

Autoimmune T cells in myasthenia gravis: heterogeneity and potential for specific immunotargeting

1996 • 56 citations

Constitutive and induced expression of the individual HLA-DR beta and alpha chain loci in different cell types

1988 • 53 citations

Stable functional expression of the adult subtype of human muscle acetylcholine receptor following transfection of the human rhabdomyosarcoma cell line TE671 with cDNA encoding the ε subunit

1996 • 49 citations

Inhibition of experimental autoimmune encephalomyelitis by a nonimmunogenic non-self peptide that binds to I-Au.

1992 • 49 citations

Constitutive and induced expression of the individual HLA-DR beta and alpha chain loci in different cell types.

1987 • 44 citations

Acetylcholine receptor antibody characteristics in myasthenia gravis. II. Patients with penicillamine-induced myasthenia or idiopathic myasthenia of recent onset.

1982 • 40 citations

Response to human acetylcholine receptor α138–199: determinant spreading initiates autoimmunity to self-antigen in rabbits

1994 • 37 citations

Tracking antigen-specific helper T cell responses

1996 • 29 citations

Stimulation of human T cells by sparse antigens captured on immunomagnetic particles

1992 • 23 citations

A method for producing monoclonal antibodies to human T-cell-receptor beta-chain variable regions.

1993 • 17 citations

Muscle Nicotinic Acetylcholine Receptor mRNA Expression in Hyperplastic and Neoplastic Myasthenia Gravis Thymusa

1998 • 17 citations

Differences in Fine Specificity of Anti-Acetylcholine Receptor Antibodies between Subgroups of Spontaneous Myasthenia Gravis of Recent Onset, and of Penicillamine Induced Myasthenia

1988 • 14 citations

Diverse patterns of unresponsiveness in an acetylcholine receptor-specific T-cell clone from a myasthenia gravis patient after engaging the T-cell receptor with three different ligands

1998 • 11 citations