Influence of excluded volume upon macromolecular structure and associations in ‘crowded” media

Macromolecular Crowding: Biochemical, Biophysical, and Physiological Consequences

1993 • 1,474 citations

Estimation of macromolecule concentrations and excluded volume effects for the cytoplasm of Escherichia coli

1991 • 1,253 citations

How crowded is the cytoplasm?

1982 • 807 citations

Cellular and Molecular Physiology of Cell Volume Regulation

2020 • 499 citations

Protein-solvent interactions

2018 • 251 citations

Model for the role of macromolecular crowding in regulation of cellular volume.

1992 • 173 citations

Tracer diffusion of globular proteins in concentrated protein solutions.

1988 • 173 citations

Macromolecular crowding and confinement in cells exposed to hypertonicity

1994 • 152 citations

Macromolecular diffusion in crowded solutions

1993 • 141 citations

Association of Glycolytic Enzymes with the Cytoskeleton

1992 • 138 citations

Macromolecular crowding and the mandatory condensation of DNA in bacteria

1996 • 129 citations

Measured change in protein solvation with substrate binding and turnover

1993 • 124 citations

Effects of "crowding" in protein solutions

1990 • 119 citations

Macromolecular crowding effects on macromolecular interactions: Some implications for genome structure and function

1993 • 110 citations

Condensation and cohesion of λ DNA in cell extracts and other media: Implications for the structure and function of DNA in prokaryotes

1995 • 90 citations

Light scattering of bovine serum albumin solutions: Extension of the hard particle model to allow for electrostatic repulsion

1982 • 80 citations

Macromolecular crowding effects on the interaction of DNA with Escherichia coli DNA-binding proteins: A model for bacterial nucleoid stabilization

1994 • 76 citations

Osmoelastic coupling in biological structures: formation of parallel bundles of actin filaments in a crystalline-like structure caused by osmotic stress

1989 • 75 citations

Heteromerous interactions among glycolytic enzymes and of glycolytic enzymes with F-actin: effects of poly(ethylene glycol)

1988 • 66 citations

Macromolecular crowding and molecular recognition

1993 • 60 citations

Assembly of a functional replication complex without ATP hydrolysis: a direct interaction of bacteriophage T4 gp45 with T4 DNA polymerase.

1993 • 54 citations

A molecular model for the dependence of the osmotic pressure of bovine serum albumin upon concentration and pH

1995 • 53 citations

Watching molecules crowd: DNA double helices under osmotic stress

1995 • 52 citations

Brownian dynamics simulations of probe and self-diffusion in concentrated protein and DNA solutions

1993 • 48 citations

Effects of dextran on the self-association of human spectrin

1995 • 47 citations

Effects of ionic strength on the regulation of Na/H exchange and K-Cl cotransport in dog red blood cells.

1995 • 47 citations

Crowding-induced organization of cytoskeletal elements: I. Spontaneous demixing of cytosolic proteins and model filaments to form filament bundles

1993 • 45 citations

‘Macromolecular crowding’ is a primary factor in the organization of the cytoskeleton

1992 • 45 citations

Structure within eukaryotic cytoplasm and its relationship to glycolytic metabolism

1996 • 43 citations

Measurement of thermodynamic nonideality arising from volume-exclusion interactions between proteins and polymers

1995 • 41 citations

Crowding-induced organization of cytoskeletal elements. III. Spontaneous bundling and sorting of self-assembled filaments with different flexibilities

1995 • 36 citations

Quantification of the Effect of Excluded Volume on Double-stranded DNA

1994 • 34 citations

Thermodynamic nonideality of enzyme solutions supplemented with inert solutes: yeast hexokinase revisited

1995 • 31 citations

The Active Species of Plasma Membrane Ca2+-ATPase Are a Dimer and a Monomer-Calmodulin Complex

1996 • 30 citations

Use of a macromolecular crowding agent to dissect interactions and define functions in transcriptional activation by a DNA-tracking protein: bacteriophage T4 gene 45 protein and late transcription.

1994 • 30 citations

Thermodynamic analysis of “preferential solvation” in protein solutions

1993 • 29 citations

Solute excluded-volume effects on the stability of globular proteins: A statistical thermodynamic theory

1998 • 26 citations

Enhancement of self-association of human spectrin by polyethylene glycol

1994 • 22 citations

Crowding-induced organization of cytoskeletal elements: II. Dissolution of spontaneously formed filament bundles by capping proteins.

1994 • 17 citations

Brownian dynamics simulation of probe diffusion in DNA: effects of probe size, charge and DNA concentration

1995 • 17 citations

Substrate modulation of aldolase B binding in hepatocytes

1996 • 17 citations

13C-NMR off-resonance rotating frame spin-lattice relaxation studies of bovine lens γ-crystallin self association: effect of ‘macromolecular crowding’

1995 • 12 citations

Self‐association of plasma membrane Ca²⁺‐ATPase by volume exclusion

1995 • 9 citations

Solute excluded‐volume effects on the stability of globular proteins: A statistical thermodynamic theory

1996 • 6 citations

Influence of Macromolecular Crowding on Intracellular Association Reactions: Possible Role in Volume Regulation

2020 • 5 citations

Preferential Interactions of Water and Cosolvents with Proteins

2024 • 4 citations

Thermodynamic Nonideality and Protein Solvation

2024 • 2 citations