Macromolecular crowding effects on macromolecular interactions: Some implications for genome structure and function

Escherichia Coli and Salmonella: Typhimurium Cellular and Molecular Biology

1987 • 4,385 citations

Physical chemistry of macromolecules

2007 • 3,839 citations

Physical chemistry of macromolecules

1962 • 2,105 citations

Macromolecular Crowding: Biochemical, Biophysical, and Physiological Consequences

1993 • 1,474 citations

Estimation of macromolecule concentrations and excluded volume effects for the cytoplasm of Escherichia coli

1991 • 1,253 citations

Physiological function of connective tissue polysaccharides.

1978 • 995 citations

Human Physiology : From Cells to Systems

1989 • 987 citations

How crowded is the cytoplasm?

1982 • 807 citations

Three-dimensional structure of the β subunit of E. coli DNA polymerase III holoenzyme: A sliding DNA clamp

1992 • 748 citations

Lac represser-operator interaction

1973 • 699 citations

On the structure of the folded chromosome of Escherichia coli

1972 • 635 citations

Diffusion-driven mechanisms of protein translocation on nucleic acids. 3. The Escherichia coli lac repressor-operator interaction: kinetic measurements and conclusions

1981 • 579 citations

Excluded volume as a determinant of macromolecular structure and reactivity

1981 • 563 citations

The effect of volume occupancy upon the thermodynamic activity of proteins: some biochemical consequences

1983 • 503 citations

Characterization of the cytoplasm of Escherichia coli K-12 as a function of external osmolarity

1991 • 478 citations

E. coli DNA binding protein HU forms nucleosome-like structure with circular double-stranded DNA

1979 • 459 citations

Protein-protein communication within the transcription apparatus

1993 • 366 citations

Interaction of the Escherichia coli HU protein with DNA

1986 • 321 citations

Histonelike proteins of bacteria.

1987 • 296 citations

Variability of the intracellular ionic environment of Escherichia coli. Differences between in vitro and in vivo effects of ion concentrations on protein-DNA interactions and gene expression.

1987 • 270 citations

Proteins Controlling the Helical Structure of DNA

1981 • 253 citations

Replication initiated at the origin (oriC) of the E. coli chromosome reconstituted with purified enzymes

1984 • 234 citations

Histone-like proteins and bacterial chromosome structure.

1988 • 202 citations

Confinement as a determinant of macromolecular structure and reactivity

1992 • 192 citations

More than just “Histone-like” proteins

1990 • 184 citations

DNA Ring Closure Mediated by Protein HU

1989 • 178 citations

Molecular Cytology of Escherichia coli

1986 • 178 citations

Histone-like proteins in the purified Escherichia coli deoxyribonucleoprotein

1977 • 176 citations

Polymer-stimulated ligation: enhanced blunt- Or cohesive-end ligation of DNA or deoxyribooligonudcleotides by T4 DNA Ugase in polymer solutions

1983 • 167 citations

The infrastructure of the mitochondrial matrix

1980 • 156 citations

In vitro transposition of bacteriophage Mu: A biochemical approach to a novel replication reaction

1983 • 150 citations

Kinetics and mechanism of the interaction of Escherichia coli RNA polymerase with the λPR promoter

1984 • 150 citations

Enzyme Reactions in Polymer Media

1971 • 144 citations

DNA dynamic flexibility and protein recognition: Differential stimulation by bacterial histone-like protein HU

1988 • 133 citations

Native Escherichia coli HU protein is a heterotypic dimer

1979 • 128 citations

High positive supercoiling in vitro catalyzed by an ATP and polyethylene glycol-stimulated topoisomerase from Sulfolobus acidocaldarius.

1985 • 114 citations

“Macromolecular crowding”: thermodynamic consequences for protein-protein interactions within the T4 DNA replication complex.

1990 • 111 citations

Ligation of single-stranded oligodeoxyribonucleotides by T4 RNA ligase

1986 • 110 citations

Salt dependence of the kinetics of the lac repressor-operator interaction: role of nonoperator deoxyribonucleic acid (DNA) in the association reaction

1981 • 110 citations

Complementary recognition in condensed DNA: Accelerated DNA renaturation

1991 • 100 citations

The influence of macromolecular crowding on thermodynamic activity: Solubility and dimerization constants for spherical and dumbbell‐shaped molecules in a hard‐sphere mixture

1990 • 97 citations

In Vivo Thermodynamic Analysis of Repression with and without Looping in lac Constructs

1993 • 90 citations

Regulation of the kinetics of the interaction of Escherichia coli RNA polymerase with the .lambda.PR promoter by salt concentration

1985 • 88 citations

lac Repressor-operator interaction

1974 • 84 citations

Effect of inert polymers on protein self‐association

1981 • 81 citations

Different substrate specificities of the two DNA ligases of mammalian cells.

1986 • 73 citations

Prokaryotic Dna In Nucleoid Structur

1976 • 66 citations

Polymer-stimulated ligation: enhanced ligation of oligo- and polynucleotides by T4 RNA ligase in polymer solutions

1984 • 61 citations

Specific association of two homologous DNA-binding proteins to the native 30-S ribosomal subunits of Escherichia coli

1978 • 61 citations

Proteins from the prokaryotic nucleoid Interaction of nucleic acids with the 15 kDa Escherichia coli histone‐like protein H‐NS

1988 • 52 citations

Effects of macromolecular crowding on the association ofE.coliribosomal particles

1988 • 52 citations

T4 polynucleotide kinase: Macromolecular crowding increases the efficiency of reaction at DNA termini

1986 • 50 citations

Isolation and characterization of nucleoid proteins from Escherichia coli

1984 • 49 citations

Potent catenation of supercoiled and gapped DNA circles by topoisomerase I in the presence of a hydrophilic polymer.

1984 • 48 citations

Multimeric complexes formed by DNA-binding proteins of low sequence specificity

1993 • 45 citations

Enhancement of recA protein-promoted DNA strand exchange activity by volume-occupying agents.

1992 • 44 citations

Macromolecular crowding extends the range of conditions under which DNA polymerase is functional

1988 • 39 citations

Influence of monovalent cations on the activity of T4 DNA ligase in the presence of polyethylene glycol

1985 • 39 citations

Conformational Transitions of Polynucleotides in Polymer Media

1974 • 38 citations

Macromolecular crowding accelerates the cohesion of DNA fragments with complementary termini

1985 • 37 citations

The bacteriophage λ O and P protein initiators promote the replication of single-stranded DNA

1984 • 33 citations

Stabilization of T4 polynucleotide kinase by macromolecular crowding

1986 • 30 citations

Excluded-volume effect of inert macromolecules on the melting of nucleic acids

1985 • 26 citations

One hundred‐fold acceleration of DNA renaturation rates in solution

1981 • 26 citations

Stimulation of intermolecular ligation withE. coliDNA ligase by high concentration of monovalent cations in polyethylene glycol solutions

1985 • 24 citations

Bacterial Chromosome Structure

1990 • 24 citations

Thermophilic HB8 DNA Ligase: Effects of Polyethylene Glycols and Polyamines on Blunt-End Ligation of DNA

1986 • 20 citations

Effects of temperature on excluded volume-promoted cyclization and concatemerization of cohesive-ended DNA longer than 0.04 Mb

1991 • 15 citations

In vitro transposition of transposon Tn3.

1990 • 14 citations

DNA ligase from Drosophila melanogaster embryos. Substrate specificity and mechanism of action.

1987 • 13 citations

Influence of Polyethylene Glycol on the Ligation Reaction with Calf Thyinus DNA Ligases I and II

1987 • 12 citations

Reinvestigation of DNA ligase I in axolotl andPleurodelesdevelopment

1991 • 8 citations