Calcium signals in T lymphocytes from old mice

Pgp‐1^hi T lymphocytes accumulate with age in mice and respond poorly to concanavalin A

1989 • 279 citations

Induction of increased calcium uptake in mouse T lymphocytes by concanavalin A and its modulation by cyclic nucleotides

1975 • 270 citations

Age-related defect in signal transduction during lectin activation of murine T lymphocytes.

1987 • 147 citations

Diminished calcium influx in lectin‐stimulated T cells from old mice

1987 • 133 citations

Diminished Calcium Signal Generation in Subsets of T Lymphocytes That Predominate in Old Mice

1990 • 89 citations

Age‐associated changes in mitogen‐induced protein phosphorylation in murine T lymphocytes

1992 • 82 citations

Reduced proliferation in T lymphocytes in aged humans is predominantly in the CD8+ subset, and is unrelated to defects in transmembrane signaling which are predominantly in the CD4+ subset

1989 • 73 citations

Uptake of extracellular Ca²⁺ and not recruitment from internal stores is essential for T lymphocyte proliferation

1988 • 72 citations

Influence of aging on intracellular free calcium and proliferation of mouse T-cell subsets from various lymphoid organs

1991 • 61 citations

Defective control of cytoplasmic calcium concentration in T lymphocytes from old mice

1989 • 55 citations

Membrane Signal Transduction in T Cells in Aging Humans^a

1989 • 51 citations

Rapid tyrosine phosphorylation of Grb2 and Shc in T cells exposed to anti-CD3, anti-CD4, and anti-CD45 stimuli: differential effects of aging

1995 • 46 citations

IgE regulation and lymphokine patterns in aging humans

1992 • 45 citations

T lymphocyte heterogeneity in old and young mice: functional defects in T cells selected for poor calcium signal generation

1989 • 44 citations

Tyrosine-Specific Protein Phosphorylation in Response to Anti-CD3 Antibody Is Diminished in Old Mice

1992 • 42 citations

Aging and the Mobilization of Intracellular Calcium by Phytohemagglutinin in Human T Cells

1989 • 35 citations

Differential sensitivity of virgin and memory T lymphocytes to calcium ionophores suggests a buoyant density separation method and a model for memory cell hyporesponsiveness to Con A.

1991 • 32 citations

Antagonistic interactions among T cell subsets of old mice revealed by limiting dilution analysis.

1995 • 23 citations

Antigen-dependent selection of T cells that are able to efficiently regulate free cytoplasmic Ca2+ levels.

1994 • 12 citations

Intracellular free Ca2+ fluxes and responses to phorbol ester in T lymphocytes from healthy elderly subjects

1992 • 12 citations