T lymphocyte heterogeneity in old and young mice: functional defects in T cells selected for poor calcium signal generation

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1983 • 52,849 citations

Early steps of lymphocyte activation bypassed by synergy between calcium ionophores and phorbol ester

1985 • 753 citations

Handbook of the Biology of Aging

1986 • 572 citations

Mouse lymphocytes with and without surface immunoglobulin: Preparative scale separation in polystyrene tissue culture dishes coated with specifically purified anti-immunoglobulin

1977 • 568 citations

Free cytoplasmic calcium concentration and the mitogenic stimulation of lymphocytes.

1983 • 466 citations

B cell stimulatory factor 1 (interleukin 4) is a potent costimulant for normal resting T lymphocytes.

1987 • 251 citations

Early Signal Transduction by the Antigen Receptor Without Commitment to T Cell Activation

1988 • 169 citations

Antibody binding to CD5 (Tp67) and Tp44 T cell surface molecules: effects on cyclic nucleotides, cytoplasmic free calcium, and cAMP-mediated suppression.

1986 • 166 citations

Thy-1-mediated T-cell activation requires co-expression of CD3/Ti complex

1987 • 159 citations

Age-related defect in signal transduction during lectin activation of murine T lymphocytes.

1987 • 147 citations

Age-associated decline in precursor frequency for different T cell-mediated reactions, with preservation of helper or cytotoxic effect per precursor cell.

1984 • 140 citations

Diminished calcium influx in lectin‐stimulated T cells from old mice

1987 • 133 citations

Calcium‐dependent activation of lymphocytes by ionophore, A23187, and a phorbol ester tumor promoter

1983 • 120 citations

Dissociation of phosphoinositide hydrolysis and Ca2+ fluxes from the biological responses of a T-cell hybridoma

1988 • 102 citations

Immunological studies of aging. IX. Impaired proliferation of T lymphocytes detected in elderly humans by flow cytometry.

1984 • 66 citations

Limiting dilution analysis of alloreactive cytotoxic precursor cells in aging mice.

1983 • 59 citations

Defective control of cytoplasmic calcium concentration in T lymphocytes from old mice

1989 • 55 citations

Population kinetics of precursors of IL 2-producing peripheral T lymphocytes: evidence for short life expectancy, continuous renewal, and post-thymic expansion.

1987 • 53 citations

BrdU‐Hoechst flow cytometry reveals regulation of human lymphocyte growth by donor‐age–related growth fraction and transition rate

1985 • 52 citations

Early biochemical events associated with lymphocyte activation in ageing. I. Evidence that Ca2+ dependent processes induced by PHA are impaired.

1981 • 51 citations

Reducèd in vitro response to concanavalin A and lipopolysaccharide in senescent mice: a function of reduced number of responding cells

1977 • 50 citations

The role of Ca2+ in activation of mature cytotoxic T lymphocytes for lysis.

1987 • 49 citations

PMA alone induces proliferation of some murine T cell clones but not others.

1986 • 28 citations

Age-related changes of mitogen responsiveness in different lymphoid organs from outbred NMRI mice

1981 • 26 citations

Inhibition by isoptin (a calcium antagonist) of the mitogenic stimulation of lymphocytes prior to the S-phase.

1978 • 23 citations

Wheat germ agglutinin activates human T lymphocytes by stimulation of phosphoinositide hydrolysis.

1986 • 18 citations

Stages of T cell activation: continued antigen dependence of IL 2-producing cells after IL 2 receptor expression.

1986 • 18 citations