BRCA1 expression levels predict distant metastasis of sporadic breast cancers

A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene BRCA1

1994 • 5,994 citations

Breast and ovarian cancer incidence in BRCA1-mutation carriers. Breast Cancer Linkage Consortium.

1995 • 1,602 citations

Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression

1995 • 585 citations

Unusual case of Smith‐Lemli‐Opitz syndrome “type II”

1995 • 572 citations

Methylation of the BRCA1 gene in sporadic breast cancer.

1997 • 384 citations

Growth retardation and tumour inhibition by BRCA1

1996 • 360 citations

The developmental pattern of Brca1 expression implies a role in differentiation of the breast and other tissues

1995 • 345 citations

Aberrant Subcellular Localization of BRCA1 in Breast Cancer

1995 • 310 citations

An evaluation of genetic heterogeneity in 145 breast-ovarian cancer families. Breast Cancer Linkage Consortium.

1995 • 268 citations

BRCA1 is a 220-kDa nuclear phosphoprotein that is expressed and phosphorylated in a cell cycle-dependent manner.

1996 • 267 citations

Immunocytochemical localization of fos protein in human breast cancers and its relationship to a series of prognostic markers and response to endocrine therapy

1995 • 208 citations

BRCA1 is a cell cycle-regulated nuclear phosphoprotein

1997 • 189 citations

Mutations at BRCA1: the medullary breast carcinoma revisited.

1998 • 165 citations

Immunocytochemical localization of BCL‐2 protein in human breast cancers and its relationship to a series of prognostic markers and response to endocrine therapy

1994 • 156 citations

Inherited susceptibility to breast cancer.

1993 • 148 citations

Medullary breast carcinoma. A reevaluation of 95 cases of breast cancer with inflammatory stroma

1988 • 142 citations

BRCA1 and BRCA2 mRNA levels are coordinately elevated in human breast cancer cells in response to estrogen.

1996 • 122 citations

An important role for BRCA1 in breast cancer progression is indicated by its loss in a large proportion of non-familial breast cancers

1998 • 121 citations

BRCA1 expression is not directly responsive to estrogen

1997 • 116 citations

A deletion unit on chromosome 17q in epithelial ovarian tumors distal to the familial breast/ovarian cancer locus.

1993 • 105 citations

Has the breast cancer gene been found?

1994 • 95 citations

Patterns of allelic loss on chromosome 17 in sporadic breast carcinomas detected by fluorescent-labeled microsatellite analysis

1997 • 83 citations

Typical medullary carcinoma of the breast: A clinical and pathological analysis of 52 cases

1995 • 57 citations

Use of reverse transcription-polymerase chain reaction methodology to detect estrogen-regulated gene expression in small breast cancer specimens.

1997 • 30 citations

High Frequency of Allelic Imbalance at the BRCA1 Region on Chromosome 17q in Both familial and Sporadic Ductal Breast Carcinomas

1994 • 21 citations

BRCA1: More than a hereditary breast cancer gene?

1995 • 18 citations