Amplifying DNA with arbitrary oligonucleotide primers.

DNA polymorphisms amplified by arbitrary primers are useful as genetic markers

1990 • 13,450 citations

Construction of a genetic linkage map in man using restriction fragment length polymorphisms.

1980 • 8,270 citations

[21] Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction

1987 • 5,745 citations

Fingerprinting genomes using PCR with arbitrary primers

1990 • 5,327 citations

Differential Display of Eukaryotic Messenger RNA by Means of the Polymerase Chain Reaction

1992 • 5,105 citations

Identification of markers linked to disease-resistance genes by bulked segregant analysis: a rapid method to detect markers in specific genomic regions by using segregating populations.

1991 • 4,472 citations

Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction.

1989 • 3,458 citations

Specific Enzymatic Amplification of DNA In Vitro: The Polymerase Chain Reaction

1986 • 3,400 citations

Distribution of repetitive DNA sequences in eubacteria and application to finerpriting of bacterial enomes

1991 • 3,175 citations

Fast and sensitive silver staining of DNA in polyacrylamide gels

1991 • 2,914 citations

Analysis of any point mutation in DNA. The amplification refractory mutation system (ARMS)

1989 • 2,480 citations

Hypervariability of simple sequences as a general source for polymorphic DNA markers

1989 • 2,356 citations

A hypervariable microsatellite revealed by in vitro amplification of a dinucleotide repeat within the cardiac muscle actin gene.

1989 • 2,011 citations

Development of reliable PCR-based markers linked to downy mildew resistance genes in lettuce

1993 • 1,360 citations

Recent Advances in the Polymerase Chain Reaction

1991 • 1,068 citations

Effects of primer-template mismatches on the polymerase chain reaction: Human immunodeficiency virus type 1 model studies

1990 • 1,037 citations

Whole genome amplification from a single cell: implications for genetic analysis.

1992 • 898 citations

A Common Language for Physical Mapping of the Human Genome

1989 • 876 citations

Genetic disease detection and DNA amplification using cloned thermostable ligase.

1991 • 803 citations

DNA diversity among clinical isolates ofHelicobacter pyloridetected by PCR-based RAPD fingerprinting

1992 • 760 citations

DNA Amplification Fingerprinting Using Very Short Arbitrary Oligonucleotide Primers

1991 • 717 citations

The fungus Armillaria bulbosa is among the largest and oldest living organisms

1992 • 681 citations

Polymerase Chain Reaction with Single-Sided Specificity: Analysis of T Cell Receptor δ Chain

1989 • 640 citations

Allele-specific enzymatic amplification of beta-globin genomic DNA for diagnosis of sickle cell anemia.

1989 • 637 citations

Arbitrarily primed PCR fingerprinting of RNA

1992 • 582 citations

Alu polymerase chain reaction: a method for rapid isolation of human-specific sequences from complex DNA sources.

1989 • 578 citations

Optimization of the annealing temperature for DNA amplificationin vitro;

1990 • 546 citations

Isothermal, in vitro amplification of nucleic acids by a multienzyme reaction modeled after retroviral replication.

1990 • 527 citations

Artifactual variation in randomly amplified polymorphic DNA banding patterns.

1993 • 507 citations

Isothermal in vitro amplification of DNA by a restriction enzyme/DNA polymerase system.

1992 • 504 citations

Amplification of human minisatellites by the polymerase chain reaction: towards DNA fingerprinting of single cells

1988 • 503 citations

Rapid identification of markers linked to a Pseudomonas resistance gene in tomato by using random primers and near-isogenic lines.

1991 • 489 citations

Identification of a Whitefly Species by Genomic and Behavioral Studies

1993 • 481 citations

Structure of DNA Polymerase I Klenow Fragment Bound to Duplex DNA

1993 • 473 citations

PLANT GENETIC CONTROL OF NODULATION

1991 • 470 citations

The use of random amplified polymorphic DNA markers in wheat

1992 • 433 citations

Monte Carlo simulations: Hidden errors from ‘‘good’’ random number generators

1992 • 425 citations

Global and local genome mapping in Arabidopsis thaliana by using recombinant inbred lines and random amplified polymorphic DNAs.

1992 • 422 citations

Isolation of molecular markers from specific chromosomal intervals using DNA pools from existing mapping populations

1991 • 389 citations

Identification of broccoli and cauliflower cultivars with RAPD markers

1991 • 388 citations

Over- and under-representation of short oligonucleotides in DNA sequences.

1992 • 375 citations

Extension of base mispairs byTaqDNA polymerase: implications for single nucleotide discrimination in PCR

1992 • 365 citations

Polymorphisms generated by arbitrarily primed PCR in the mouse: application to strain identification and genetic mapping

1991 • 362 citations

Segregation of random amplified DNA markers in F1 progeny of conifers

1991 • 345 citations

Random Number Generators

1962 • 337 citations

Pollen-mediated introgression and hybrid speciation in Louisiana irises.

1991 • 315 citations

Base mispair extension kinetics. Comparison of DNA polymerase alpha and reverse transcriptase.

1990 • 293 citations

DNA Diagnostics—Molecular Techniques and Automation

1988 • 286 citations

Potential taxonomic use of random amplified polymorphic DNA (RAPD): a case study in Brassica

1992 • 270 citations

Use of single-primer DNA amplifications in genetic studies of peanut (Arachis hypogaea L.)

1992 • 262 citations

Isolation and characterization of allelic losses and gains in colorectal tumors by arbitrarily primed polymerase chain reaction.

1992 • 253 citations

Use of the random amplified polymorphic DNA polymerase chain reaction (RAPD-PCR) to detect DNA polymorphisms in aphids (Homoptera: Aphididae)

1992 • 239 citations

POLYMERASE CHAIN REACTION STRATEGY

1992 • 225 citations

Isolation of molecular markers for tomato (L. esculentum) using random amplified polymorphic DNA (RAPD)

1991 • 220 citations

Genetic Analysis with Random Amplified Polymorphic DNA Markers

1993 • 216 citations

Differentiation of Fusarium solani f. sp. cucurbitae races 1 and 2 by random amplification of polymorphic DNA

1991 • 215 citations

Minimal homology requirements for PCR primers

1989 • 214 citations

Rapid identification of genetic variation and pathotype of Leptosphaeria maculans by random amplified polymorphic DNA assay

1991 • 213 citations

The ligase chain reaction in a PCR world.

1991 • 202 citations

Parentage determination in maize hybrids using the arbitrarily primed polymerase chain reaction (AP-PCR)

1991 • 195 citations

Side chains involved in catalysis of the polymerase reaction of DNA polymerase I from Escherichia coli.

1992 • 194 citations

Characterization of genetic identities and relationships of Brassica oleracea L. via a random amplified polymorphic DNA assay

1992 • 194 citations

Chance and Statistical Significance in Protein and DNA Sequence Analysis

1992 • 193 citations

Genetic fingerprinting of Theobroma clones using randomly amplified polymorphic DNA markers

1992 • 188 citations

Targeted gene walking polymerase chain reaction

1991 • 186 citations

Typing of Listeria strains by random amplification of polymorphic DNA

1992 • 183 citations

Rapid, nonradioactive detection of mutations in the human genome by allele-specific amplification.

1989 • 176 citations

Single Tree Genetic Linkage Mapping in Conifers Using Haploid DNA from Megagametophytes

1992 • 166 citations

Use of RAPD markers to determine the genetic diversity of diploid, wheat genotypes

1992 • 161 citations

Use of pooled DNA samples to detect linkage disequilibrium of polymorphic restriction fragments and human disease: studies of the HLA class II loci.

1985 • 160 citations

The Polymerase Chain Reaction in an Anemic Mode: How to Avoid Cold Oligodeoxyribonuclear Fusion

1991 • 158 citations

Concentration of primer and template qualitatively affects products in random-amplified polymorphic DNA PCR.

1993 • 156 citations

Oligonucleotide and Amplification Fingerprinting of Wild Species and Cultivars of Banana (Musa spp.)

1992 • 154 citations

Segregating random amplified polymorphic DNAs (RAPDs) in Betula alleghaniensis

1992 • 151 citations

Direct sequencing of the gene for Maryland/German familial amyloidotic polyneuropathy type II and genotyping by allele-specific enzymatic amplification

1989 • 148 citations

Self-sustained sequence replication (3SR): an isothermal transcription-based amplification system alternative to PCR.

1991 • 148 citations

RAPD analysis ofCampylobacterisolates: DNA fingerprinting without the need to purify DNA

1992 • 148 citations

Comparison of HIV-1 and avian myeloblastosis virus reverse transcriptase fidelity on RNA and DNA templates.

1992 • 145 citations

Genetic segregation of random amplified polymorphic DNA in diploid cultivated alfalfa

1992 • 143 citations

Leptospira species categorized by arbitrarily primed polymerase chain reaction (PCR) and by mapped restriction polymorphisms in PCR-amplified rRNA genes

1993 • 141 citations

Patterns of inheritance with RAPD molecular markers reveal novel types of polymorphism in the honey bee

1992 • 139 citations

Primer-template interactions during DNA amplification fingerprinting with single arbitrary oligonucleotides

1992 • 129 citations

Detection of ras point mutations by polymerase chain reaction using mutation-specific, inosine-containing oligonucleotide primers

1989 • 127 citations

Development and chromosomal localization of genome-specific markers by polymerase chain reaction in Brassica

1991 • 124 citations

Diversity among clinical isolates of Histoplasma capsulatum detected by polymerase chain reaction with arbitrary primers

1992 • 123 citations

Amplification fragment length polymorphism in Brucella strains by use of polymerase chain reaction with arbitrary primers

1992 • 121 citations

DNA amplification fingerprinting: A strategy for genome analysis

1991 • 120 citations

DNA amplification fingerprinting of bacteria

1992 • 119 citations

High outcrossing rates maintain male and hermaphrodite individuals in populations of the flowering plant Datisca glomerata

1992 • 114 citations

Sequence-tagged site (STS) content mapping of human chromosomes: theoretical considerations and early experiences.

1991 • 103 citations

Detection of DNA sequence polymorphisms among wheat varieties

1992 • 96 citations

PCR buffer optimization with uniform temperature regimen to facilitate automation.

1993 • 88 citations

Parentage analysis using RAPD PCR

1992 • 83 citations

Base mispair extension kinetics. Binding of avian myeloblastosis reverse transcriptase to matched and mismatched base pair termini.

1992 • 81 citations

DNA amplification polymorphisms of the cultivated mushroom Agaricus bisporus

1992 • 81 citations

Pedigree assessment using RAPD-DGGE in cereal crop species

1993 • 79 citations

Subtyping of Streptococcus uberis by DNA amplification fingerprinting

1992 • 79 citations

The random amplification of polymorphic DNA for fingerprinting plants.

1992 • 76 citations

Constancy of RAPD primer amplification strength among distantly related taxa of flowering plants

1993 • 74 citations

A comparative study of randomly amplified polymorphic DNA analysis and conventional phage typing for epidemiological studies of Listeria monocytogenes isolates

1992 • 71 citations

Genotype relationships inMicroseris elegans (Asteraceae, Lactuceae) revealed by DNA amplification from arbitrary primers (RAPDs)

1992 • 67 citations

Differentiation of Isolates ofDiscula umbrinella(Teleomorph:Apiognomonia errabunda) from Beech, Chestnut, and Oak Using Randomly Amplified Polymorphic DNA Markers

1992 • 65 citations

Multilocus markers for mouse genome analysis: PCR amplification based on single primers of arbitrary nucleotide sequence

1992 • 53 citations

Enhanced detection of polymorphic DNA by multiple arbitrary amplicon profiling of endonuclease-digested DNA: identification of markers tightly linked to the supernodulation locus in soybean

1993 • 52 citations

Random sequence oligonucleotide primers detect polymorphic DNA products which segregate in inbred strains of mice

1992 • 50 citations

Simultaneous determination of two antioxidants, uric and ascorbic acid, in animal tissue by high-performance liquid chromatography

1991 • 49 citations

rPCR: a powerful tool for random amplification of whole RNA sequences.

1993 • 49 citations

DNA amplification fingerprinting of the Azolla-Anabaena symbiosis

1993 • 38 citations

Identification of Casuarina-Frankia strains by use of polymerase chain reaction (PCR) with arbitrary primers

1992 • 35 citations

Polymorphisms revealed by PCR with single, short-sized, arbitrary primers are reliable markers for mouse and rat gene mapping

1992 • 34 citations

Identification ofCasuarina-Frankiastrains by use of polymerase chain reaction (PCR) with arbitrary primers

1992 • 28 citations

The Wheel of Fortune

1993 • 24 citations

DNA polymerase I (Klenow fragment): Role of the structure and length of a template in enzyme recognition

1989 • 24 citations

DNA Fingerprinting: MAAPing out a RAPD Redefinition?

1992 • 21 citations

Plant Genetic Control of Nodulation in Legumes

1991 • 19 citations

The frequency of oligonucleotides in mammalian genic regions

1989 • 16 citations

Single primer amplification of avian genomic DNA detects polymorphic LOCI

1991 • 8 citations

DAF-amplified fragments can be used as markers for DNA from pulse field gels.

1993 • 4 citations