Attenuation of acute hypoxic pulmonary vasoconstriction and hypoxic pulmonary hypertension in mice by inhibition of Rho-kinase

Rho GTPases in cell biology

2002 • 4,662 citations

Ca²⁺Sensitivity of Smooth Muscle and Nonmuscle Myosin II: Modulated by G Proteins, Kinases, and Myosin Phosphatase

2003 • 1,913 citations

Signaling from Rho to the Actin Cytoskeleton Through Protein Kinases ROCK and LIM-kinase

1999 • 1,581 citations

Post-transcriptional Regulation of Endothelial Nitric Oxide Synthase mRNA Stability by Rho GTPase

1998 • 1,034 citations

Rho-Kinase Mediates Hypoxia-Induced Downregulation of Endothelial Nitric Oxide Synthase

2002 • 465 citations

Long-Term Treatment With a Rho-Kinase Inhibitor Improves Monocrotaline-Induced Fatal Pulmonary Hypertension in Rats

2003 • 401 citations

Agonists Trigger G Protein-mediated Activation of the CPI-17 Inhibitor Phosphoprotein of Myosin Light Chain Phosphatase to Enhance Vascular Smooth Muscle Contractility

2000 • 336 citations

Timing of cyclin D1 expression within G1 phase is controlled by Rho

2001 • 318 citations

The pulmonary circulation of homozygous or heterozygous eNOS-null mice is hyperresponsive to mild hypoxia

1999 • 312 citations

Rho signals to cell growth and apoptosis

2001 • 312 citations

ET_A and ET_B Receptors Modulate the Proliferation of Human Pulmonary Artery Smooth Muscle Cells

2002 • 310 citations

Rho-kinase as a Novel Therapeutic Target in Treatment of Cardiovascular Diseases

2002 • 264 citations

Human Urotensin II–Induced Contraction and Arterial Smooth Muscle Cell Proliferation Are Mediated by RhoA and Rho-Kinase

2001 • 263 citations

Rho and Rho Kinase Mediate Thrombin-Stimulated Vascular Smooth Muscle Cell DNA Synthesis and Migration

1999 • 260 citations

Enhanced endothelin-1 and endothelin receptor gene expression in chronic hypoxia

1994 • 255 citations

Pulmonary Vasoconstriction and Hypertension in Mice With Targeted Disruption of the Endothelial Nitric Oxide Synthase (NOS 3) Gene

1997 • 251 citations

Rho/Rho kinase signaling mediates increased basal pulmonary vascular tone in chronically hypoxic rats

2004 • 239 citations

Sustained pulmonary hypertension and right ventricular hypertrophy after chronic hypoxia in mice with congenital deficiency of nitric oxide synthase 3.

1998 • 232 citations

ROCK and mDia1 antagonize in Rho-dependent Rac activation in Swiss 3T3 fibroblasts

2002 • 212 citations

Induction of Serotonin Transporter by Hypoxia in Pulmonary Vascular Smooth Muscle Cells

1999 • 208 citations

Inhibition of Rho-Associated Kinase Results in Suppression of Neointimal Formation of Balloon-Injured Arteries

2000 • 199 citations

Anti-anginal Effect of Fasudil, a Rho-Kinase Inhibitor, in Patients With Stable Effort Angina: A Multicenter Study

2002 • 192 citations

Involvement of Rho-Kinase in Angiotensin II–Induced Hypertrophy of Rat Vascular Smooth Muscle Cells

2000 • 177 citations

Thrombin Suppresses Endothelial Nitric Oxide Synthase and Upregulates Endothelin-Converting Enzyme-1 Expression by Distinct Pathways

2001 • 163 citations

Inhibition of sustained hypoxic vasoconstriction by Y‐27632 in isolated intrapulmonary arteries and perfused lung of the rat

2000 • 159 citations

Relative contributions of endothelial, inducible, and neuronal NOS to tone in the murine pulmonary circulation

1999 • 158 citations

Rho activation in excitatory agonist-stimulated vascular smooth muscle

2001 • 146 citations

Rho-Kinase Activation Is Involved in Hypoxia-Induced Pulmonary Vasoconstriction

2001 • 139 citations

Agonist-induced changes in the phosphorylation of the myosin- binding subunit of myosin light chain phosphatase and CPI17, two regulatory factors of myosin light chain phosphatase, in smooth muscle

2002 • 117 citations

Reduced Hypoxic Pulmonary Vascular Remodeling by Nitric Oxide From the Endothelium

2001 • 114 citations

Growth of the Heart and Lungs in Hypoxic Rodents: A Model of Human Hypoxic Disease

1974 • 112 citations

Prevention and reversal of hypoxic pulmonary hypertension by calcium antagonists.

1984 • 104 citations

Overexpression of Endothelial Nitric Oxide Synthase Attenuates Cardiac Hypertrophy Induced by Chronic Isoproterenol Infusion.

2002 • 87 citations

Involvement of Rho-Kinase and the Actin Filament Network in Angiotensin II–Induced Contraction and Extracellular Signal–Regulated Kinase Activity in Intact Rat Mesenteric Resistance Arteries

2001 • 71 citations

Inhibition of High K+-Induced Contraction by the ROCKs Inhibitor Y-27632 in Vascular Smooth Muscle: Possible Involvement of ROCKs in a Signal Transduction Pathway

2003 • 67 citations

Hypoxia inhibits increased ET_B receptor-mediated NO synthesis in hypertensive rat lungs

1999 • 51 citations

Rho plays an important role in angiotensin II-induced hypertrophic responses in cardiac myocytes

2000 • 45 citations

Untitled

2000 • 38 citations

Nitric oxide-dependent pulmonary vasodilation in polycythemic rats

2000 • 33 citations

ROCK and mDia1 antagonize in Rho-dependent Rac activation in Swiss 3T3 fibroblasts

2003 • 32 citations

Pulmonary vascular adaptations to augmented polycythemia during chronic hypoxia

1995 • 30 citations

Role of rho-kinase activity in angiotensin II-induced contraction of rabbit clitoral cavernosum smooth muscle

2002 • 26 citations

Hypoxic pulmonary hypertension in the mast cell-deficient mouse

1983 • 25 citations

Rhoキナーゼ長期阻害は内皮性NO合成とは無関係に低酸素誘発肺高血圧を改善する(Long-term Inhibition of Rho-kinase Ameliorates Hypoxia-Induced Pulmonary Hypertension in Mice Independent of Endothelial NO Synthase)

2004 • 2 citations