Desensitization of muscarinic acetylcholine receptors: possible relation to receptor heterogeneity and phosphoinositides

Inositol phospholipids and cell surface receptor function

1975 • 2,458 citations

A study of the ‘desensitization’ produced by acetylcholine at the motor end‐plate

1957 • 1,457 citations

Muscarinic suppression of a novel voltage-sensitive K+ current in a vertebrate neurone

1980 • 1,423 citations

Pirenzepine distinguishes between different subclasses of muscarinic receptors

1980 • 1,299 citations

Muscarinic Cholinergic Binding in Rat Brain

1974 • 1,214 citations

Voltage-clamp analysis of muscarinic excitation in hippocampal neurons

1982 • 1,061 citations

THE CHOLINERGIC LIMBIC SYSTEM: PROJECTIONS TO HIPPOCAMPAL FORMATION, MEDIAL CORTEX, NUCLEI OF THE ASCENDING CHOLINERGIC RETICULAR SYSTEM, AND THE SUBFORNICAL ORGAN AND SUPRA-OPTIC CREST

1967 • 966 citations

ELECTROPHYSIOLOGY OF HIPPOCAMPAL NEURONS: II. AFTER-POTENTIALS AND REPETITIVE FIRING

1961 • 683 citations

The binding of agonists to brain muscarinic receptors.

1978 • 656 citations

Characteristics of CA1 neurons recorded intracellularly in the hippocampalin vitro slice preparation

1975 • 508 citations

Cholinergic Mechanisms and Psychopharmacology

1978 • 437 citations

Acetylcholine‐sensitive cells in the cerebral cortex

1963 • 416 citations

Afterpotential generation in hippocampal pyramidal cells.

1981 • 401 citations

Phosphatidyldmositol hydrolysis: A multifunctional transducing mechanism

1981 • 341 citations

Cholinergic excitation of mammalian hippocampal pyramidal cells

1982 • 328 citations

Pharmacological properties of acetylcholine‐sensitive cells in the cerebral cortex

1963 • 321 citations

BIOCHEMICAL STUDIES ON MUSCARINIC ACETYLCHOLINE RECEPTORS

1976 • 314 citations

Brain cholinergic dysfunction and memory in aged rats

1980 • 257 citations

Acetylcholine increases the breakdown of triphosphoinositide of rabbit iris muscle prelabelled with [32P] phosphate

1977 • 256 citations

Ionic mechanisms of cholinergic excitation in mammalian hippocampal pyramidal cells

1982 • 245 citations

The excitatory action of acetylcholine on hippocampal neurones of the guinea pig and rat maintained in vitro

1981 • 244 citations

PHOSPHOLIPIDS IN SYNAPTIC FUNCTION

1979 • 235 citations

Desensitization at the frog neuromuscular junction: a biphasic process

1982 • 211 citations

Muscarinic agonist binding and phospholipid turnover in brain.

1983 • 185 citations

[3H] pirenzepine selectively identifies a high affinity population of muscarinic cholinergic receptors in the rat cerebral cortex

1982 • 184 citations

The effect of septal nuclei stimulation on the release of acetylcholine from the rabbit hippocampus

1975 • 176 citations

Regulation of binding properties of the nicotinic receptor protein by cholinergic ligands in membrane fragments from Torpedo marmorata.

1975 • 169 citations

Age-related alterations in neurotransmitter receptors: An electrophysiological and biochemical analysis

1981 • 167 citations

Multiple actions of acetylcholine at a muscarinic receptor studied in the rat hippocampal slice

1982 • 150 citations

Differential Stimulation of Inositol Phospholipid Turnover in Brain by Analogs of Oxotremorine

1984 • 134 citations

The cholinergic pharmacology of hippocampal pyramidal cells: A microiontophoretic study

1976 • 126 citations

Acetylcholine induced modulation of hippocampal pyramidal neurons

1981 • 115 citations

Characterization of muscarinic acetylcholine receptors from mouse brain: evidence for regional heterogeneity and isomerization.

1979 • 115 citations

A STUDY OF THE MUSCARINIC RECEPTOR BY GEL ELECTROPHORESIS

1979 • 112 citations

Ligand interactions with cholinergic receptor-enriched membranes from Torpedo: influence of agonist exposure on receptor properties.

1976 • 102 citations

Muscarinic receptor: regulation by guanine nucleotides, ions, and N-ethylmaleimide.

1981 • 82 citations

Conformational changes in muscarinic receptors may produce diminished cholinergic neurotransmission and memory deficits in aged rats

1985 • 81 citations

The acetylcholine receptor in the rat hippocampus; nicotinic, muscarinic or both?

1978 • 77 citations

Binding of agonists and antagonists to muscarinic receptors

1976 • 68 citations

Acetycholine stimulation of the phosphodiesteratic cleavage of guinea pig brain phosphoinositides

1968 • 47 citations

Correlation Between the Binding Properties and Pharmacological Responses of Muscarinic Receptors

1978 • 37 citations

Analysis of acetylcholinesterase synthesis and transport in the rat hippocampus: recovery of acetylcholinesterase activity in the septum and hippocampus after administration of diisopropylfluorophosphate

1974 • 35 citations

Acetylcholine as an Excitatory and Inhibitory Transmitter in the Mammalian Central Nervous System

1979 • 34 citations

Muscarine-sensitive voltage-dependent potassium current in cultured murine spinal cord neurons

1983 • 32 citations

Regional heterogeneity of muscarinic receptors of mouse brain

1979 • 27 citations

Affinity labeling of muscarinic receptors in rat cerebral cortex with a photolabile antagonist.

1982 • 26 citations

Agonist‐Mediated Conformational Changes of Muscarinic Receptors in Rat Brain

1982 • 25 citations

Hippocampal muscarinic receptor loss following trimethyl tin administration

1985 • 22 citations

Localization of hippocampal muscarinic receptors after kainic acid lesion of CA3 and fimbria-fornix transection

1982 • 17 citations