Agonist‐Mediated Conformational Changes of Muscarinic Receptors in Rat Brain

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1973 • 12,522 citations

On the nature of allosteric transitions: A plausible model

1965 • 8,699 citations

The binding of agonists to brain muscarinic receptors.

1978 • 656 citations

ON THE COOPERATIVITY OF BIOLOGICAL MEMBRANES

1967 • 439 citations

On the application of “a plausible model” of allosteric proteins to the receptor for acetylcholine

1967 • 425 citations

Simultaneous determination of beta-1 and beta-2-adrenergic receptors in tissues containing both receptor subtypes.

1979 • 418 citations

BIOCHEMICAL STUDIES ON MUSCARINIC ACETYLCHOLINE RECEPTORS

1976 • 314 citations

Influence of sulfhydryl reagents and heavy metals on the functional state of the muscarinic acetylcholine receptor in rat brain.

1978 • 134 citations

Stereospecific binding as a tool in attempts to localize and isolate muscarinic receptors

1974 • 130 citations

Adenylate cyclase: The role of magnesium and other divalent cations

1980 • 130 citations

Cholinergic activity regulates muscarinic receptors in central nervous system cultures.

1979 • 117 citations

Characterization of muscarinic acetylcholine receptors from mouse brain: evidence for regional heterogeneity and isomerization.

1979 • 115 citations

Recent advances in receptor chemistry

1980 • 114 citations

A STUDY OF THE MUSCARINIC RECEPTOR BY GEL ELECTROPHORESIS

1979 • 112 citations

Muscarinic acetylcholine receptor regulation by accelerated rate of receptor loss

1979 • 111 citations

On the analysis of pharmacological experiments in terms of an allosteric receptor model.

1973 • 99 citations

STEREOSPECIFIC IN VlTRO BINDING OF [³H]DEXETIMIDE TO BRAIN MUSCARINIC RECEPTORS

1979 • 74 citations

The influence of guanyl-5′-yl imidodiphosphate and sodium on muscarinic receptor binding in the rat brain and longitudinal muscle of the rat ileum

1980 • 71 citations

The importance of thiol- and disulfide groups in agonist and antagonist binding to the muscarinic receptor.

1979 • 66 citations

Inhibition of Lysosomal Plasminogen Activator Activity in Experimental Shock

1973 • 66 citations

Agonist-specific reverse regulation of muscarinic receptors by transition metal ions and guanine nucleotides

1980 • 64 citations

Regulation of muscarinic receptor binding by guanine nucleotides and N‐ethylmaleimide

1980 • 62 citations

Molecular size of muscarinic acetylcholine receptors of rat brain

1980 • 53 citations

Tissue Fractionation in Neurobiochemistry: an Analytical Tool or a Source of Artifacts

1977 • 51 citations

Conversion between configurational states of the muscarinic receptor in rat brain

1977 • 49 citations

Inactivation of beta-adrenergic receptors by N-ethylmaleimide: permissive role of beta-adrenergic agents in relation to adenylate cyclase activation.

1980 • 46 citations

Characterization of digitonin‐solubilized muscarinic receptor from rat brain

1978 • 44 citations

Cardiac muscarinic cholinergic receptor sites: Opposing regulation by divalent cations and guanine nucleotides of receptor-agonist interaction

1980 • 41 citations

Inactivation of beta-adrenergic receptors by N-ethylmaleimide in S49 lymphoma cells. Agonist induction of functional receptor heterogeneity.

1980 • 39 citations

Distinction between Two Subpopulations of β₁‐Adrenergic Receptors in Human Adipose Cells

1981 • 39 citations

The receptor concept in evolution

1977 • 35 citations

CHARACTERIZATION AND SUBCELLULAR LOCALIZATION OF BRAIN MUSCARINIC RECEPTORS LABELLED IN VIVO BY [³H]DEXETIMIDE

1979 • 32 citations

Induced interconversion of agonist affinity states in muscarinic receptor from mice brain: Effects of temperature and sugars

1980 • 28 citations

Biochemical characterization of the BETA-adrenergic receptor of the frog erythrocyte

1979 • 17 citations

Differential effect of N‐ethyl maleimide on muscarinic agonist binding in rat and bovine brain membranes

1980 • 8 citations

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