Time course of behavioral changes following basal forebrain cholinergic damage in rats: Environmental enrichment as a therapeutic intervention

The Rat Brain in Stereotaxic Coordinates

1982 • 53,055 citations

The rat brain in stereotaxic coordinates

1983 • 28,962 citations

The Hippocampus as a Cognitive Map

1978 • 8,087 citations

The hippocampus as a cognitive map

1979 • 5,527 citations

The Cholinergic Hypothesis of Geriatric Memory Dysfunction

1982 • 5,422 citations

A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data

1988 • 3,033 citations

Exercise: a behavioral intervention to enhance brain health and plasticity

2002 • 2,571 citations

Neural consequences of enviromental enrichment

2000 • 2,376 citations

CENTRAL CHOLINERGIC SYSTEMS AND COGNITION

1997 • 1,328 citations

NT-3, BDNF, and NGF in the developing rat nervous system: Parallel as well as reciprocal patterns of expression

1990 • 1,238 citations

Experience-Induced Neurogenesis in the Senescent Dentate Gyrus

1998 • 1,135 citations

Impaired Recognition Memory in Rats after Damage to the Hippocampus

2000 • 718 citations

Cognitive functions of cortical acetylcholine: toward a unifying hypothesis

1997 • 664 citations

Cholinergic function and intellectual decline in Alzheimer's disease

1986 • 605 citations

Long-Term Environmental Enrichment Leads to Regional Increases in Neurotrophin Levels in Rat Brain

2000 • 538 citations

Basal forebrain lesions in monkeys disrupt attention but not learning and memory [published erratum appears in J Neurosci 1995 Mar;15(3): following table of contents]

1994 • 496 citations

Complete and selective cholinergic denervation of rat neocortex and hippocampus but not amygdala by an immunotoxin against the p75 NGF receptor

1994 • 406 citations

Behavioural, histochemical and biochemical consequences of selective immunolesions in discrete regions of the basal forebrain cholinergic system

1994 • 335 citations

Selective immunotoxic lesions of basal forebrain cholinergic cells: Effects on learning and memory in rats.

2013 • 334 citations

Differential effects on spatial navigation of immunotoxin-induced cholinergic lesions of the medial septal area and nucleus basalis magnocellularis

1994 • 326 citations

Selective Behavioral and Neurochemical Effects of Cholinergic Lesions Produced by Intrabasalis Infusions of 192 IgG-Saporin on Attentional Performance in a Five-Choice Serial Reaction Time Task

2002 • 315 citations

Age, Experience and the Changing Brain

1998 • 304 citations

The Nucleus Basalis Magnocellularis Cholinergic System: One Hundred Years of Progress

1997 • 291 citations

Behavioral, biochemical, histological, and electrophysiological effects of 192 IgG-saporin injections into the basal forebrain of rats

1994 • 256 citations

Selective immunotoxic lesions of basal forebrain cholinergic cells: Effects on learning and memory in rats.

1995 • 243 citations

The role of cholinergic projections from the nucleus basalis in memory

1991 • 213 citations

Therapeutic Effects of Environmental Enrichment on Cognitive Function and Tissue Integrity Following Severe Traumatic Brain Injury in Rats

2001 • 202 citations

Environmental enrichment: Effects on spatial memory and hippocampal CREB immunoreactivity

2001 • 188 citations

Neural lesioning with ribosome-inactivating proteins: suicide transport and immunolesioning

1992 • 183 citations

Selective Lesioning of the Basal Forebrain Cholinergic System by Intraventricular 192 IgG–saporin: Behavioural, Biochemical and Stereological Studies in the Rat

1995 • 179 citations

192 immunoglobulin G-saporin produces graded behavioral and biochemical changes accompanying the loss of cholinergic neurons of the basal forebrain and cerebellar Purkinje cells

1995 • 175 citations

Exposure to Environmental Complexity Promotes Recovery of Cognitive Function after Traumatic Brain Injury

1996 • 169 citations

The role of cortical cholinergic afferent projections in cognition: impact of new selective immunotoxins

2000 • 160 citations

Decreased synaptic density in aged brains and its prevention by rearing under enriched environment as revealed by synaptophysin contents

1994 • 160 citations

Injection of IgG 192-saporin into the medial septum produces cholinergic hypofunction and dose-dependent working memory deficits

1996 • 149 citations

Effects of enriched environments with different durations and starting times on learning capacity during aging in rats assessed by a refined procedure of the Hebb‐Williams maze task

2002 • 143 citations

Cholinergic Modulation of Visual Attention and Working Memory: Dissociable Effects of Basal Forebrain 192-IgG-saporin Lesions and Intraprefrontal Infusions of Scopolamine

2004 • 137 citations

Hippocampal brain‐derived neurotrophic factor gene regulation by exercise and the medial septum

2002 • 131 citations

Experience, memory, and the brain.

1984 • 125 citations

Age-changes of brain synapses and synaptic plasticity in response to an enriched environment

1999 • 115 citations

The behavioral functions of the cholinergic basalforebrain : lessons from 192 IgG‐SAPORIN

1998 • 112 citations

Social environment alters both ontogeny of dopamine innervation of the medial prefrontal cortex and maturation of working memory in gerbils (Meriones unguiculatus)

1998 • 111 citations

Time course of cholinergic and monoaminergic changes in rat brain after immunolesioning with 192 IgG-saporin

1994 • 104 citations

Exogenous BDNF, NT-3 and NT-4 differentially regulate neurite outgrowth in cultured hippocampal neurons

2000 • 104 citations

Intervention with environmental enrichment after experimental brain trauma enhances cognitive recovery in male but not female rats

2002 • 102 citations

Combined lesions of cholinergic and serotonergic neurons in the rat brain using 192 IgG‐saporin and 5,7‐dihydroxytryptamine: neurochemical and behavioural characterization

2000 • 100 citations

A double dissociation between serial reaction time and radial maze performance in rats subjected to 192 IgG‐saporin lesions of the nucleus basalis and/or the septal region

2003 • 100 citations

Threshold relationship between lesion extent of the cholinergic basal forebrain in the rat and working memory impairment in the radial maze

1999 • 98 citations

Selective lesion of cholinergic neurons in the medial septum by 192 IgG-saporin impairs learning in a delayed matching to position T-maze paradigm

2002 • 96 citations

Dementia: Animal models of the cognitive impairments following damage to the basal forebrain cholinergic system

1990 • 81 citations

Different effects on learning ability after injection of the cholinergic immunotoxin ME20.4IgG-saporin into the diagonal band of Broca, basal nucleus of Meynert, or both in monkeys.

1999 • 66 citations

Intraseptal injections of 192 IgG saporin produce deficits for strategy selection in spatial-memory tasks

1998 • 65 citations

Decline in visual attention and spatial memory in aged rats

1999 • 63 citations

Early Environmental Stimulation Produces Long-Lasting Changes on β-Adrenoceptor Transduction System

1995 • 63 citations

Behavioural, histological and immunocytochemical consequences following 192 IgG-saporin immunolesions of the basal forebrain cholinergic system

2001 • 60 citations

Intraparenchymal infusions of 192 IgG-saporin: development of a method for selective and discrete lesioning of cholinergic basal forebrain nuclei

1999 • 56 citations

Different effects on learning ability after injection of the cholinergic immunotoxin ME20.4IgG-saporin into the diagonal band of Broca, basal nucleus of Meynert, or both in monkeys.

1999 • 56 citations

Mnemonic Deficits in Animals Depend upon the Degree of Cholinergic Deficit and Task Complexity

2002 • 55 citations

Early neonatal 192 IgG saporin induces learning impairments and disrupts cortical morphogenesis in rats

2002 • 51 citations

192IgG-saporin-induced immunotoxic lesions of cholinergic basal forebrain system differentially affect glutamatergic and GABAergic markers in cortical rat brain regions

1995 • 49 citations

Cholinergic fiber aberrations in nucleus basalis lesioned rat and Alzheimer's disease

1992 • 47 citations

Selective Antibody-Induced Cholinergic Cell and Synapse Loss Produce Sustained Hippocampal and Cortical Hypometabolism with Correlated Cognitive Deficits

2001 • 47 citations

Reactions to spatial and nonspatial change in two inbred strains of mice: Further evidence supporting the hippocampal dysfunction hypothesis in the DBA/2 strain

1995 • 44 citations

Neurotrophin Effects on Survival and Expression of Cholinergic Properties in Cultured Rat Septal Neurons under Normal and Stress Conditions

1996 • 43 citations

Selective immunolesions of CH4 cholinergic neurons do not disrupt spatial memory in rats

2002 • 42 citations

The role of the septo-hippocampal cholinergic projection in T-maze rewarded alternation

2003 • 41 citations

Cholinergic immunolesions by 192IgG‐saporin—a useful tool to simulate pathogenic aspects of alzheimer's disease

1997 • 39 citations

Effects of hippocampal cholinergic deafferentation on learning strategy selection in a visible platform version of the water maze

2003 • 37 citations

Effects of lateral and medial septal lesions on exploratory behavior in the albino rat

1980 • 33 citations

Behavioral and Biochemical Consequences of Combined Lesions of the Medial Septum/Diagonal Band and Nucleus Basalis in the Rat When Ibotenic Acid, Quisqualic Acid, and AMPA Are Used

1994 • 33 citations

Evidence for altered α2-adrenoceptor function following isolation-rearing in the rat

1994 • 33 citations

Effects of septal cholinergic lesion on rat exploratory behavior in an open-field

2003 • 31 citations

The basal forebrain cholinergic system and object memory in the rat

1996 • 30 citations

192 IgG-saporin lesions to the nucleus basalis magnocellularis (nBM) disrupt acquisition of learning set formation

2003 • 27 citations

Effects of Selective Immunotoxic Lesions on Learning and Memory

2003 • 24 citations

Neuroplasticity, the aging brain, and Alzheimer's disease.

1992 • 24 citations

Differential changes in rat cholinergic parameters subsequent to immunotoxic lesion of the basal forebrain nuclei

2001 • 23 citations

Cholinergic lesions of the rat brain by ibotenic acid and 192 IgG-saporin: effects on somatostatin, substance P and neuropeptide Y levels in the cerebral cortex and the hippocampus

1998 • 17 citations

Basal forebrain damage and object-recognition in rats

1998 • 12 citations

Chapter 32 Injury and repair of central cholinergic neurons

1990 • 11 citations

Long-term production of choline acetyltransferase in the CNS after transplantation of fibroblasts modified with a regulatable vector

2004 • 5 citations