Thyroid hormone–sympathetic interaction and adaptive thermogenesis are thyroid hormone receptor isoform–specific

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Thermogenic mechanisms in brown fat.

1984 • 1,593 citations

Towards a molecular understanding of adaptive thermogenesis

2000 • 1,560 citations

Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese

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Influence of Thyroid Hormones on l-α-Glycerophosphate Dehydrogenases and Other Dehydrogenases in Various Organs of the Rat

1965 • 638 citations

The Molecular Basis of Thyroid Hormone Action

1994 • 541 citations

Abnormal heart rate and body temperature in mice lacking thyroid hormone receptor alpha 1

1998 • 503 citations

Mice devoid of all known thyroid hormone receptors are viable but exhibit disorders of the pituitary-thyroid axis, growth, and bone maturation

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Different functions for the thyroid hormone receptors TRalpha and TRbeta in the control of thyroid hormone production and post-natal development

1999 • 411 citations

Adrenergic activation of triiodothyronine production in brown adipose tissue

1983 • 395 citations

Thyroid Hormone Control of Thermogenesis and Energy Balance

1995 • 376 citations

Thyroid hormone receptor β is essential for development of auditory function

1996 • 363 citations

Intracellular conversion of thyroxine to triiodothyronine is required for the optimal thermogenic function of brown adipose tissue.

1987 • 345 citations

The T3Ralpha gene encoding a thyroid hormone receptor is essential for post-natal development and thyroid hormone production

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Mice with a targeted mutation in the thyroid hormone β receptor gene exhibit impaired growth and resistance to thyroid hormone

2000 • 269 citations

A high-affinity subtype-selective agonist ligand for the thyroid hormone receptor

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The Thyroid Hormone Receptor-β-Selective Agonist GC-1 Differentially Affects Plasma Lipids and Cardiac Activity¹

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The Isolation and Metabolism of Brown Fat Cells

1967 • 173 citations

Thyroid Hormone Action on Liver, Heart, and Energy Expenditure in Thyroid Hormone Receptor β-Deficient Mice**Presented in part at the 69th Annual Meeting of the American Thyroid Association Meeting, November 14–17, 1996, San Diego, California. This study was supported in part by the National Institutes of Health Grant DK-17050 and the Seymour J. Abrams Thyroid Research Center; a grant from the Ministry of Health and Welfare, Japan (to H.S.); and Grant-in-Aid for Scientific Research (09671044) …

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Hormone Selectivity in Thyroid Hormone Receptors

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Stimulation of hepatic mitochondrial alpha-glycerophosphate dehydrogenase and malic enzyme by L-triiodothyronine. Characteristics of the response with specific nuclear thyroid hormone binding sites fully saturated.

1977 • 151 citations

INTERRELATIONS BETWEEN THYROXIN AND ADRENALIN IN THE REGULATION OF OXYGEN CONSUMPTION IN THE ALBINO RAT1

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Delineation of thyroid hormone-responsive sequences within a critical enhancer in the rat uncoupling protein gene.

1995 • 117 citations

Tissue-specific actions of thyroid hormone: insights from animal models.

2000 • 115 citations

Cardiovascular phenotype and temperature control in mice lacking thyroid hormone receptor-β or both α₁ and β

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Optimal response of key enzymes and uncoupling protein to cold in BAT depends on local T3 generation

1987 • 110 citations

Full Expression of Uncoupling Protein Gene Requires the Concurrence of Norepinephrine and Triiodothyronine

1988 • 100 citations

Evidence that decreased heart rate in thyroid hormone receptor-α1-deficient mice is an intrinsic defect

1998 • 97 citations

Novel insight from transgenic mice into thyroid hormone resistance and the regulation of thyrotropin

1999 • 92 citations

Thyroid hormone and norepinephrine signaling in brown adipose tissue. II: Differential effects of thyroid hormone on beta 3-adrenergic receptors in brown and white adipose tissue.

1995 • 91 citations

ROLE OF THE THYROID IN METABOLIC RESPONSES TO A COLD ENVIRONMENT

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Tissue-specific regulation of two functional malic enzyme mRNAs by triiodothyronine

1985 • 86 citations

Triiodothyronine Induces the Transcription of the Uncoupling Protein Gene and Stabilizes Its mRNA in Fetal Rat Brown Adipocyte Primary Cultures

1996 • 80 citations

Thyroid Hormone Regulates Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel (HCN2) mRNA in the Rat Heart

1999 • 80 citations

AVP V₁ receptor-mediated decrease in Cl⁻ efflux and increase in dark cell number in choroid plexus epithelium

1999 • 79 citations

Effects of thyroid hormone on norepinephrine signaling in brown adipose tissue. I. Beta 1- and beta 2-adrenergic receptors and cyclic adenosine 3',5'-monophosphate generation.

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α₁- and β-Adrenergic Agents Cause Synergistic Stimulation of the Iodothyronine Deiodinase in Rat Brown Adipocytes*

1989 • 69 citations

Interactions among receptors, thyroid hormone response elements, and ligands in the regulation of the rat uncoupling protein gene expression by thyroid hormone.

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Adenosine 3',5'-monophosphate and thyroid hormone control of uncoupling protein messenger ribonucleic acid in freshly dispersed brown adipocytes.

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Impaired metabolic response to nerve stimulation in brown adipose tissue of hypothyroid rats

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Thyroid Hormone Receptor Gene Knockouts

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The Thyroid Hormone Receptor- -Selective Agonist GC-1 Differentially Affects Plasma Lipids and Cardiac Activity

2000 • 54 citations

Evidence of UCP1-independent regulation of norepinephrine-induced thermogenesis in brown fat

2000 • 54 citations

Hormone Selectivity in Thyroid Hormone Receptors

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Rat MitochondrialGlycerol-3-Phosphate DehydrogenaseGene: Multiple Promoters, High Levels in Brown Adipose Tissue, and Tissue-Specific Regulation by Thyroid Hormone

1998 • 53 citations

Thyroid Hormone Action on Liver, Heart, and Energy Expenditure in Thyroid Hormone Receptor -Deficient Mice

1998 • 50 citations

Thyroxine 5′-Deiodination Mediates Norepinephrine-Induced Lipogenesis in Dispersed Brown Adipocytes*

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Development of Compensatory Thermogenesis in Response to Overfeeding in Hypothyroid Rats¹

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Effects of hypothyroidism on brown adipose tissue adenylyl cyclase activity.

1996 • 44 citations

Changes in β1- and β2-adrenergic receptor mRNA levels in brown adipose tissue and heart of hypothyroid rats

1991 • 39 citations

Delineation of thyroid hormone-responsive sequences within a critical enhancer in the rat uncoupling protein gene

1995 • 31 citations

Presence and mRNA expression of T3 receptors in differentiating rat brown adipocytes

1996 • 28 citations

Development of Compensatory Thermogenesis in Response to Overfeeding in Hypothyroid Rats

1999 • 22 citations

Adenosine 3',5'-monophosphate and thyroid hormone control of uncoupling protein messenger ribonucleic acid in freshly dispersed brown adipocytes

1992 • 22 citations

Thyroid hormone and norepinephrine signaling in brown adipose tissue. II: Differential effects of thyroid hormone on beta 3-adrenergic receptors in brown and white adipose tissue

1995 • 20 citations

OXYGEN CONSUMPTION OF BROWN ADIPOSE TISSUE IN NORMAL AND HYPOTHYROID MICE

1967 • 20 citations

Effects of thyroid hormone on norepinephrine signaling in brown adipose tissue. I. Beta 1- and beta 2-adrenergic receptors and cyclic adenosine 3',5'-monophosphate generation

1995 • 19 citations

Expression of c-erbAα, c-erbAβ and Rev-erbAα mRNA during the conversion of brown adipose tissue into white adipose tissue

1996 • 19 citations

Effects of hypothyroidism on brown adipose tissue adenylyl cyclase activity

1996 • 16 citations

Thyroxine 5'-Deiodination Mediates Norepinephrine-Induced Lipogenesis in Dispersed Brown Adipocytes

1998 • 14 citations

Interactions among receptors, thyroid hormone response elements, and ligands in the regulation of the rat uncoupling protein gene expression by thyroid hormone

1996 • 14 citations

12th International Thyroid Congress

2000 • 7 citations